CAS: 6326-83-6; Bis(Carboxymethyl)Trithiocarbonate

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CAS号75-15-0 二硫化碳 | CAS号79-11-8 氯乙酸 | CAS号6310-26-5 Aceticacid, [[(... | CAS号584-10-1 Carbonotrithioi... | CAS号108748-13-6 4-thioxo-3,5-di... | CAS号7748-25-6 potassium mon°C... | CAS号140-89-6 乙基黄原酸钾 | CAS号3926-62-3 氯乙酸钠 | CAS号25554-84-1 O-乙基-S-羧基甲基二硫代碳酸 | CAS号68-11-1 硫代乙醇酸(TGA) | CAS号10574-70-6 4-Thiazolidinon... | CAS号387-27-9 3-(4-氟苯基)-2-硫亚基... | CAS号57669-54-2 2-硫氧基-3-[4-(三氟甲... | CAS号4807-55-0 3-甲基罗丹宁 | CAS号53723-88-9 (5-巯基-1,3,4-噻二唑... | CAS号21346-21-4 3-(4-羟基苯基)-2-硫代... | CAS号21494-64-4 3-丁基-2-硫代噻唑烷-4-酮 | CAS号23176-01-4 ethyl 2-(4-oxo-... | CAS号23517-71-7 4-Thiazolidinon... | CAS号23538-04-7 3-[(4-chlorophe...

📜Alkaline Earth Salt Of/the/ Methylsulfuric Acid置于水体系中,化学反应生成 双(羧甲基)三硫代碳酸盐
参考文献:Holmberg,Journal Fur Praktische Chemie (Leipzig 1954),1905,Vol. <2>71,P. 294
标题:Holmberg,Journal Fur Praktische Chemie (Leipzig 1954),1905,Vol. <2>71,P. 294

专利信息

专利号:US-2009111737-A1
优先权日:1999-05-24
标题:Novel antibacterial agents
发明人：CHRISTENSEN BURTON G; MORAN EDMUND J; GRIFFIN JOHN H; JUDICE J KEVIN; MU YONGQI; PACE JOHN L; MAMMEN MATHAI; AGGEN JAMES
权利人:CHRISTENSEN BURTON G; MORAN EDMUND J; GRIFFIN JOHN H; JUDICE J KEVIN; MU YONGQI; PACE JOHN L; MAMMEN MATHAI; AGGEN JAMES
摘要:This invention relates to novel multibinding compounds (agents) that are antibacterial agents. The multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands in their monovalent (i.e., unlinked) state have the ability to bind to a an enzyme involved in cell wall biosynthesis and metabolism, a precursor used in the synthesis of the bacterial cell wall and/or the bacterial cell surface thereby interfere with the synthesis and/or metabolism of the cell wall. In particular the multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands hasn a ligand domain capable of binding to penicillin binding proteins, a transpeptidase enzyme, a substrate of a transpeptidase enzyme, a beta-lactamase enzyme, pencillinase enzyme, cephalosporinase enzyme, a transglycoslase enzyme, or a transglycosylase enzyme substrate; Preferably, the ligands are selected from the beta lactam or glycopeptide class of antibacterial agents.

专利号:US-9988348-B1
优先权日:2017-06-06
标题 :Synthesis and antimicrobial use of a trithiocarbonate derivative
发明人：GABR YAHIA NASSER MABKHOT; KHALED JAMAL MOHAMMED ALI; SULTAN MUJEEB ABDULLAH SAEED; AL-SHOWIMAN SALIM S; ALHARBI NAIYF SULTAN HELIAL ALALOI; GHABBOUR HAZEM AHMED
权利人:UNIV KING SAUD
摘要:A method for preparing a trithiocarbonate derivative compound includes reacting ethyl cyanoacetate, carbon disulfide (CS 2 ) and ethyl chloroacetate in the presence of potassium carbonate (K 2 CO 3 ) in an organic solvent to produce 2,2′-(thiocarbonylbis(sulfanediyl))diacetate compound, represented by the structural formula:

专利号:US-7179794-B2
优先权日:1998-06-08
标题 :Multivalent macrolide antibiotics
发明人：GRIFFIN JOHN H; PACE JOHN L
权利人:THERAVANCE INC
摘要:Disclosed are multibinding compounds which include macrolide antibiotics, aminoglycosides, lincosamides, oxazolidinones, streptoramins, tetracycline and/or other compounds which bind to bacterial ribosomal RNA and/or to one or more proteins involved in ribosomal protein synthesis in the bacterium, which are useful in treating bacterial infections. The compounds adversely affect protein expression and have an antibacterial effect. The multibinding compounds of this invention containing from 2 to 10 ligands covalently attached to one or more linkers. Each ligand is macrolide antibiotic, aminoglycoside, lincosamide, oxazolidinone, streptogramin, tetracycline or other compound which binds to bacterial ribosomal RNA and/or one or more proteins involved in ribosomal protein synthesis in the bacterium.