CAS: 624-45-3; Methyl 4-Oxopentanoate

相似化合物

123-76-2 13984-50-4 2046-21-1

上下游产品

CAS号67-56-1 甲醇 | CAS号9004-34-6 微晶纤维素 | CAS号50-99-7 D(+)-无水葡萄糖 | CAS号123-76-2 乙酰丙酸 | CAS号57-48-7 果糖 | CAS号108-24-7 乙酸酐 | CAS号292638-85-8 丙烯酸甲酯 | CAS号57-50-1 蔗糖 | CAS号1917-64-2 5-(甲氧基甲基)呋喃-2-甲醛 | CAS号67-47-0 5-羟甲基糠醛 | CAS号106287-95-0 2-Methyl-7-(p-m... | CAS号3859-41-4 1,3-环戊二酮 | CAS号4188-88-9 乙酰丙烯酸甲酯 | CAS号58917-25-2 (R)-γ-戊内酯 | CAS号111043-99-3 (R)-(-)-γ-hydro... | CAS号19041-15-7 (S)-γ-Valerolactone | CAS号553-90-2 草酸二甲酯 | CAS号89-91-8 二甲氧基乙酸甲酯 | CAS号106-65-0 琥珀酸二甲酯 | CAS号2052-15-5 乙酰丙酸丁酯

3-戊烯酸置于硫酸,三氟化硼乙醚,间氯过氧苯甲酸体系中,用 氯仿 作为反应溶剂,化学反应生成 乙酰丙酸甲酯
参考文献:三氟化硼催化的3,4-环氧酯的区域选择性开环和异构化反应
标题:三氟化硼催化的3,4-环氧酯的区域选择性开环和异构化反应
摘要:提出了3,4-环氧酯与醇的有效开环以产生4-烷氧基-3-羟基酯,并使用三氟化硼作为催化剂将其异构化为4-酮酯.两种转化都是用于合成上述命名的有用化合物的简单而有效的方法.
DOI:10.1021/ol201378W

专利信息

专利号:US-2007015260-A1
优先权日:2002-03-14
标 题:Synthesis of synthons for the manufacture of bioactive compounds
发明人：WONG CHI-HUEY; LIU JUNJIE; DESANTIS GRACE; BURK MARK
权利人:SCRIPPS RESEARCH INST
摘要:The present invention is based on the discovery that 2-deoxyribose-5-phosphate aldolase (DERA, EC 4.1.2.4) and variants thereof can be used to catalyze sequential asymmetric aldol reactions between a wide variety of donor and acceptor aldehydes. The reaction products typically contain at least two new stereogenic centers and can be produced in enantiomerically pure form. As such, DERA catalyzed asymmetric aldol chemistry can be exploited to produce synthons for the synthesis of a variety of bioactive molecules.

专利号:US-9422216-B2
优先权日:2012-08-27
标 题:Method for synthesis of lactic acid and its derivatives and catalyst for preparing same
发明人：ZHOU XIAOPING
权利人:MICROVAST POWER SYSTEMS CO LTD; MICROVAST POWER SYSTEMS CO LTD
摘要:The present disclosure provides a catalyst for preparing lactic acid and derivatives thereof, comprising at least one of metallic compounds MX n , wherein M is selected from Na, K, Mg, Ca, Sr, Ba, Al, Ga, In, Sn, Sb, Bi, Cr, Mn, Fe, Co, Ni and Zn, and n is an integer of 1 to 6. The present disclosure further provides a method for synthesis of lactic acid and derivatives thereof, wherein at least one raw material including carbohydrates, at least one alcohol, at least one of the aforesaid catalysts and at least one solvent are heated to react to prepare lactic acid and derivatives thereof.

专利号:US-9096519-B2
优先权日:2013-01-10
标 题 :Process for the synthesis of ketones from internal alkenes
发明人：MORANDI BILL; GRUBBS ROBERT H; WICKENS ZACHARY K; LERCH MICHAEL M
权利人:CALIFORNIA INST OF TECHN
摘要:The present invention is directed to methods for oxidizing internal olefins to ketones. In various embodiments, each method comprising contacting an organic substrate, having an initial internal olefin, with a mixture of (a) a biscationic palladium salt; and (b) an oxidizing agent; dissolved or dispersed in a solvent system to form a reaction mixture, said solvent system comprising at least one C 2-6 carbon nitrile and optionally at least one secondary alkyl amide, said method conducted under conditions sufficient to convert at least 50 mol % of the initial internal olefin to a ketone, said ketone positioned on a carbon of the initial internal olefin. The transformation occurs at room temperature and shows wide substrate scope. Applications to the oxidation of seed oil derivatives and a bioactive natural product are described.

专利号:US-2003180804-A1
优先权日:2001-10-29
标题:Solid phase synthesis of chemical libraries
发明人：PRYOR KENT E; LEWIS RONALD D; BROWN JASON W
权利人:CORVAS INT INC
摘要:The present invention provides compounds and compound libraries that are useful as protease modulators. The compounds and compound libraries are preferably made using the methods of the present invention which utilize peptide synthesis and combinatorial chemistry methods on a solid phase.

专利号:WO-2014148928-A1
优先权日:2013-03-21
标 题:Method for incorporating protecting acetal and acetal ester groups, and its application for the protection of hydroxyl function
发明人：MARKIEWICZ WOJCIECH; TOÅš-MARCINIAK AGNIESZKA; CHMIELEWSKI MARCIN
权利人:INST CHEMII BIOORG POLSKIEJ AKADEMII NAUK
摘要:The present invention is the method for incorporation of acetal and acetal ester groups for protection of hydroxyl function. The method is applied in particular in the processes of RNA synthesis. The method can be employed in the synthesis of nucleosides with acetal and acetal ester groups for the protection of hydroxyl functions. The method according to the invention consists of the reaction of an organic compound containing at least one hydroxyl group, soluble in an aprotic solvent, with a compound of the general formula 1, R 1 -S-CH 2 -O-R 2 (1) in the presence of SnCl 4 , in an aprotic solvent. In the second aspect, the present invention is the method of protecting the hydroxyl function, particularly in position 2', in nucleoside derivatives, based on the incorporation of an acetal or acetal ester group.

专利号:US-2024308991-A1
优先权日:2021-01-15
标 题:Process for the synthesis of reactive carbohydrates including antigen precursors for conjugation with a carrier material
发明人：SHIAO TZE CHIEH; MIGNANI SERGE; MOFFETT SERGE; VISHWAKARMA RAM
权利人:KORANEX CAPITAL
摘要:Carbohydrate of Formula (A)where R1 is H and n an integer from 1 to 5, is synthesized by reacting, under heating, compound (A0)with HO—(CH2)n—CHâ•?CH2 in the presence of an acid capable of liberating a proton, and cooling the reaction mixture to obtain a cooled mixture comprising compound (A).Carbohydrate of Formula (AAPG)where R2 is a monovalent protecting group, PG is a divalent protecting group and n an integer from 1 to 5, is synthesized by reacting, in the presence of a metal-containing zeolite, compound of Formula (APG)with compound of Formula (A1)where X is —I, —Br, —Cl, —CN, —OTf (Triflate), —OMs (Mesylate), —OTs (Tosylate), methylsulfate, or trichloroacetimidate. Deprotection of compound (AAPG) forms compound (AA)Carbohydrates (A) and (AA) can be coupled with a thiolated linker to form glycoconjugate precursors, which in turn are conjugatable with a carrier material such as a protein, peptide or polypeptide.