CAS: 53857-57-1; 5-Bromo-1H-Indazole

上下游产品

5-bromobenzopyrazole-3-carboxylic acid 3-Diazo-3H-indazol N-nitroso-anilide)acetic acid-(4-bromo-2-methyl-N-nitroso-anilide) 3,5-dibromoindazole 3,5-dibromoindazole 2-Methyl-5-bromo-2H-indazole 5-bromo-1-methyl-1H-indazole 5-bromo-3-iodo-1H-indazole

3-氨基-5-溴-1H-吲唑置于亚硝酸异丁酯,次磷酸体系中,用 乙醇,水 作为反应溶剂,化学反应 3.0H,以40%的收率获得产物5-溴吲唑
参考文献:6-Aminoimidazo[1,2-B]Pyridazine Analogs As Rho Kinase Inhibitors For The Treatment Of Rho Kinase-Mediated Diseases And Conditions
标题:6-Aminoimidazo[1,2-B]Pyridazine Analogs As Rho Kinase Inhibitors For The Treatment Of Rho Kinase-Mediated Diseases And Conditions
摘要:本文披露了使用6-氨基咪唑并[1,2-B]吡啶嗪类似物治疗rho激酶介导的疾病或rho激酶介导的症状的方法,包括控制眼压和治疗青光眼.本文还披露了用于治疗眼部疾病如青光眼,并且对控制眼压有益的眼科药物组合物,该组合物包括有效量的6-氨基咪唑并[1,2-B]吡啶嗪类似物.

专利信息

专利号:US-9994567-B2
优先权日:2015-05-22
标 题:Synthesis of heterocyclic compounds
发明人：IBRAHIM PRABHA N; LIN JACK; SPEVAK WAYNE; ZHANG JIAZHONG
权利人:PLEXXIKON INC
摘要:Provided herein are intermediates and processes useful for facile synthesis of compounds of formula (I): n nor a pharmaceutically acceptable salt, a solvate, a tautomer, an isomer or a deuterated analog thereof, wherein Q, P 1 and P 2 are as defined in this disclosure.

专利号:US-9695169-B2
优先权日:2012-05-31
标 题:Synthesis of heterocyclic compounds
发明人：IBRAHIM PRABHA N
权利人:PLEXXIKON INC
摘要:Provided herein are intermediates and processes useful for facile synthesis of biologically active molecules.

专利号:US-9573939-B2
优先权日:2011-09-08
标题:Substituted benzofuran compounds and methods of use thereof for the treatment of viral diseases
发明人：MCCOMAS CASEY C; LIVERTON NIGEL J; HABERMANN JOERG; KOCH UWE; NARJES FRANK; LI PENG; PENG XUANJIA; SOLL RICHARD; WU HAO; PALANI ANANDAN; DAI XING; LIU HONG; HE SHUWEN; DANG QUN
权利人:MCCOMAS CASEY C; LIVERTON NIGEL J; HABERMANN JOERG; KOCH UWE; NARJES FRANK; LI PENG; PENG XUANJIA; SOLL RICHARD; WU HAO; PALANI ANANDAN; DAI XING; LIU HONG; HE SHUWEN; DANG QUN; MERCK SHARP & DOHME; MSD ITALIA SRL
摘要:The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

专利号:US-10226449-B2
优先权日:2013-12-20
标 题:Heterocyclic modulators of lipid synthesis and combinations thereof
发明人：HEUER TIMOTHY SEAN; OSLOB JOHAN D; MCDOWELL ROBERT S; JOHNSON RUSSELL; YANG HANBIAO; EVANCHIK MARC; ZAHARIA CRISTIANA A; CAI HAIYING; HU LILY W; DUKE GREGORY; OHOL-GUPTA YAMINI; O'FARRELL MARIE
权利人:3 V BIOSCIENCES INC
摘要:Heterocyclic modulators of lipid synthesis are provided as well as pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; and methods of treating conditions characterized by dysregulation of a fatty acid synthase pathway by the administration of such compounds and combinations of such compounds and other therapeutic agents.

专利号:US-9428502-B2
优先权日:2012-07-03
标题:Heterocyclic modulators of lipid synthesis
发明人：OSLOB JOHAN D; MCDOWELL ROBERT S; JOHNSON RUSSELL; YANG HANBIAO; EVANCHIK MARC; ZAHARIA CRISTIANA A; CAI HAIYING; HU LILY W; WAGMAN ALLAN S
权利人:3-V BIOSCIENCES INC
摘要:Heterocyclic modulators of lipid synthesis are provided as well as pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; and methods of treating conditions characterized by disregulation of a fatty acid synthase pathway by the administration of such compounds.

专利号:US-2018002332-A1
优先权日:2015-05-22
标题 :Synthesis of heterocyclic compounds