CAS: 50913-12-7; N2-(Tert-Butoxycarbonyl)-Nw-Nitro-D-Arginine
该化合物是一种化学化合物,具有特定功能组和结构特征."Boc"(乙基-丁基氧碳基)组是氨基功能的保护群体,在浸渍合成中很常见,允许有选择的反应,而不会干扰矿山.在螺旋边链上存在硝基化合物(NO2),具有独特的反应力和特性,在各种化学应用中,包括药物研制和浸泡合成中都有用.这种化合物一般在室温下是固态的,有机溶剂是溶液,有利于有机合成.分子结构有助于其生物活动,特别是在药理学方面,氨基酸的改变会影响基于丙基药物的功效和特性.在处理该化合物时,应注意安全防范措施,因为硝基化合物对减少和可能构成危害敏感.
- 英文名称N2-(Tert-Butoxycarbonyl)-Nw-Nitro-D-Arginine
- 中文名称N'-硝基-N-叔丁氧羰基-D-精氨酸
- IUPAC名称(R)-5-((amino(nitroamino)methylene)amino)-2-((tert-butoxycarbonyl)amino)pentanoic acid
- 其它别名B°C-D-NITROARGININE; B°C-D-ARG(NO2)-OH; B°C-D-ARGININE(NITRO); B°C-D-ARGININE(NO2)-OH; B°C-N-OMEGA-NITRO-D-ARGININE; OMEGA-NITRO-B°C-D-ARGININE; N-ALPHA-T-BUTOXYCARBONYL-N-G-NITRO-D-ARGININE; N-ALPHA-T-B°C-NG-NITRO-D-ARGININE
- CAS编号50913-12-7
- MFCD编号:MFCD00038091
- FDA UNII编号:9Q358K64GP
- 分子式:C11H21N5O6分子量:319.31
- 产品CID: 1497852
- 产品分类生物化工 → 氨基酸及其衍生物 → 精氨酸类衍生物
物理性质
MSDS等安全信息
合成工艺路线路线简述
海关参考信息
- 2905122000-异丙醇
2905143000-叔丁醇
2912110000-甲醛
2912120000-乙醛 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
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专利信息
专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.
