CAS: 39635-32-0; 2,3,3',5,5'-Pentachlorobiphenyl

该化合物是一种氯化联苯化合物,具有明确的分子结构,在2,3',3',5和5'位置上有五个氯替代体,这种结构具有很高的化学稳定性和抗热降解性,在专门的工业应用中有用,其特征清晰的结构使得可以在环境和毒理学研究中进行精确的分析参考,特别是在检测和量化多氯联苯同族元素方面.该化合物的纯性和一致性对于气体色谱学和质谱学的校准标准至关重要.由于其持久性,处理需要严格遵守安全议定书,以尽量减少环境和健康风险.

英文名称2,3,3',5,5'-Pentachlorobiphenyl
中文名称2,3,3',5,5'-五氯-1,1'-联苯
IUPAC名称1,2,5-trichloro-3-(3,5-dichlorophenyl)benzene
其它别名2,3,3',5,5'-五氯联苯
CAS编号39635-32-0
MFCD编号:MFCD00792646
FDA UNII编号:60947GZH3P
分子式:C12H5Cl5分子量:326.43
产品CID: 1408162
产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

相似结构搜索
产品信息参考;;;;
InChIKey: QMUDLTGWHILKHH-UHFFFAOYSA-N
1S/C12H5Cl5/c13-7-1-6(2-8(14)3-7)10-4-9(15)5-11(16)12(10)17/h1-5H
计算化学: 氢键受体数*氢键供体数*可旋转键数1.0

MSDS等安全信息

GHS符号GHS07
警示词Warning
危险描述H302-H315-H319-H335
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
安全声明The mechanism of action varies with the specific PCB. Dioxin-like PCBs bind to the aryl hydrocarbon receptor, which disrupts cell function by altering the transcription of genes, mainly be inducing the expression of hepatic Phase I and Phase II enzymes, especially of the cytochrome P450 family. Most of the toxic effects of PCBs are believed to be results of Ah receptor binding. Other PBCs are believed to interfere with calcium channels and/or change brain dopamine levels. PCBs can also cause endocrine disurption by altering the production of thyroid hormones and binding to estrogen receptors, which can stimulate the growth of certain cancer cells and produce other estrogenic effects, such as reproductive dysfunction. They will bioaccumulate by binding to receptor proteins such as uteroglobin. (A3, A4, A30, A66)

上下游产品

3,5-dichloroiodobenzene 1,2,5-trichloro-3-iodobenzene

合成工艺路线路线简述

📜3,5-二氯碘苯,1-碘-2,3,5-三氯苯置于铜体系中,用 N,N-二甲基甲酰胺用作溶剂,化学反应生成2,3,3',5,5'-五氯联苯
参考文献:Physical,Spectral And Chromatographic Properties Of All 209 Individual Pcb Congeners
标题:Physical,Spectral And Chromatographic Properties Of All 209 Individual Pcb Congeners
摘要:Physical,Spectral And Chromatographic Data For All 209 Individual Pcb Congeners Is Presented. The Individual Congeners Were Synthesized And Then Isolated And Purified. Recent Emphasis On The Source Of The Toxicity Of Commercial Pcb Formulations Has Increased The Need For A Complete Set Of The Pcb Congeners. Through The Use Of Two Capillary Gc Columns: 40% octadecyl/ 15% Phenyl Methyl Siloxane And 50% Phenyl Methyl Siloxane,It Was Possible To Separate 201 Pcb Congeners With Only Four Unresolved Pairs. The Data Compiled In This Study For All 209 Congeners Will Aid In The Identification Of Selected Individual Components Of These Environmental Pollutants. The Use Of This Data Also Presents The Opportunity For The Improved Quantification Of The Commercial Pcb Formulations.
Doi:10.1016/0045-6535(95)00140-4