CAS: 371-27-7; 2,2,2-Trifluoroethyl Butyrate

相似化合物

371-26-6 217186-74-8 79392-43-1

上下游产品

2,2,2-trifluoroethanol butyryl chloride bis(2,2,2-trifluoroethoxy)triphenylphosphorane butyric acid 6''-O-butanoylnaringin (S)-hept-6-en-2-ol Butyric acid (R)-1-methyl-hex-5-enyl ester 2-Phenyl-2-hydroxyethyl butyrate

📜丁酸酐,2,2,2-三氟乙醇置于对甲苯磺酸体系中,用90%的收率获得正丁酸2,2,2-三氟乙酯
参考文献:Synthesis Of The Stereoisomers Of A Novel Antibacterial Agent And Interpretation Of Their Relative Activities In Terms Of A Theoretical Model Of The Penicillin Receptor
标题:Synthesis Of The Stereoisomers Of A Novel Antibacterial Agent And Interpretation Of Their Relative Activities In Terms Of A Theoretical Model Of The Penicillin Receptor
摘要:2,2-二甲基-3-(2'-羟丙基)-5-羧基-δ3-1,4-噻嗪(1)是一种设计的抗菌剂.根据对青霉素与青霉素结合蛋白模型的复合物如何反应的分析,1含有一个功能基团(c=n),可以根据假定的反应enz-Oh + C = N-> Enz-O-C-Nh与受体的丝氨酸羟基反应.化合物1还包含额外的取代基,旨在将o-H和c=n基团相对于酶-底物复合物中的位置设计成一种几何构型,试图重现两种反应物的最佳接近几何构型.一个最重要的假设是这种最佳几何构型可以从头计算.在对1的第一次制备中,(+/-)-5-甲基-4-己烯-2-醇(2)被转化为(+/-)-2-巯基-2-甲基-5-叔丁基二甲基硅氧基-3-己酮(7)的锂盐,然后与n-叔丁氧羰基-D-和l-丝氨酸-β-内酯(3)缩合.合成完成后,用甲酸去保护,然后在水中环化.2的r和s对映体现已被获得,并通过r-和s-丙烯氧化物与由β,β-二甲基乙烯基溴制备的有机金属试剂反应,确定了醇的绝对构型.R醇也通过脂肪酶催化的三氟乙基丁酸酯转酯化和三氟乙基酯的化学水解获得.2的r和s对映体转化为7的r和s对映体,然后与3的r和s对映体缩合,以在约95%光学纯度形式中产生化学不稳定的1的各立体异构体.抗菌活性存在于5S,8R和5S,8S异构体中.这些发现与理论模型一致.希望可以改进引物结构1的稳定性,以便进行与识别青霉素的酶的结合实验.
Doi:10.1139/v94-134

专利信息

专利号:US-5403937-A
优先权日:1993-04-30
标 题 :Process for preparing intermediates for the synthesis of antifungal agents
发明人：SAKSENA ANIL K; GIRIJAVALLABHAN VIYYOOR M; PIKE RUSSELL E; WANG HAIYAN; LOVEY RAYMOND G; LIU YI-TSUNG; GANGULY ASHIT K; MORGAN WILLIAM B; ZAKS ALEKSEY
权利人:SCHERING CORP
摘要:Disclosed is a process for preparing chiral compounds of the formula (I) (I) wherein: X1 and X2 are independently F or Cl; and E is -SO2R2, wherein R2 is C1-C6 alkyl, -C6H4CH3 or -CF3; its enantiomer and racemates thereof, useful in the synthesis of tetrahydrofuran azole antifungals. Novel compounds of the formula or wherein: X1 and X2 are independently F or Cl; B represents -C(O)Q* or -CH2OR''; Q* represents a chiral auxiliary group; R'' represents a hydroxy protecting group selected from -CH2C6H5, or -C(O)R1, wherein R1 is C1-C6 alkyl; and A represents Cl, Br, I or triazolyl; are also disclosed.

专利号:US-11773118-B2
优先权日:2019-02-21
标 题:Methods of making high enantioselective secondary alcohols
发明人：YU CHENG-DER TONY; HSIEH YIH-HUANG; LIN SHU-YI; CHAO CHIN-SHENG; HSIEH YIN-CHENG; LAI MING-TAIN
权利人:OBI PHARMA INC
摘要:A new process to synthesis of compound OBI-3424 R-form and S-form products is provided. The “R-formâ€? compound OBI-3423 was first synthesized with 48% overall yield from compound OBI-3424-5 by installation of the labile phosphate motif at later stage. The stereo chemistry is established by 5 steps chemo-enzyme combination synthesis to afford 99% optical purity. After then, the “S-formâ€? compound OBI-3424 is prepared with improving overall yield of 54% from compound OBI-3424-5. The stereo chemistry is established by 4 steps combination of chemo-enzyme synthesis with excellent optical purity of 99%.

专利号:WO-2025038471-A1
优先权日:2023-08-11
标 题:Flow synthesis of organic adsorbents and a flow photo-reactor for the adsorption and degradation of contaminants in water sources
发明人：KHALIL SAFIYA; VERDUZCO RAFAEL; ALAZMI ABDULLAH
权利人:UNIV RICE WILLIAM M
摘要:A method of making a covalent organic framework includes continuously feeding a first precursor and a second precursor to a flow reactor; heating, and mixing the first and second precursors; nucleating and growing the covalent organic framework; and continuously outputting the covalent organic framework from the third section of the flow reactor. A photo-reactor for treating contaminated water includes: a light source; an enclosed channel around the light source; a cover comprising one or more lights illuminating the enclosed channel; and a covalent organic framework cased within the enclosed channel, where the covalent organic framework is photo-catalytically active for degrading a contaminant in the contaminated water so as to produce treated water. A method of treating contaminated water includes feeding the contaminated water to the photo-reactor and contacting the contaminated water with the covalent organic framework.

专利号:US-12247239-B2
优先权日:2019-06-21
标题:Chemo-enzymatic process for the preparation of homopropargylic alcohol
发明人：CHANDRASEKHAR SRIVARI; GHOSH SUBHASH; KRISHNA AVULA SHIVA; REDDY CHADA RAJI; SUDHAKAR GANGARAJULA; THENKRISHNAN KUMARAGURU; PABBARAJA SRIHARI; MAINKAR PRATHAMA SATYENDRA; NASAM RAJESH
权利人:COUNCIL SCIENT IND RES; COUNCIL SCIENT IND RES
摘要:The present invention relates to an enzymatic process for preparation of optically pure enantiomers of homopropargylic alcohol compounds of formula I, which are useful intermediates for the synthesis of Halichondrin B and analogs. wherein, P is H or an alcohol protecting group, n is an integer ranging from 0-12.

专利号:EP-2038260-B1
优先权日:2006-06-16
标题:Stereoselective synthesis of (s)-1-methyl-3-phenylpiperazine
发明人：VAN VLIET MICHIEL CHRISTIAN ALEXANDER; KEMPERMAN GERARDUS JOHANNES; SCHREUDER GOEDHEIJT MARCEL
权利人:ORGANON NV
摘要:This invention provides for a compound according to Formula (1), wherein R1 is methyl, ethyl, n-propyl, isopropyl, benzyl or 2-haloethyl and the use thereof in a method to prepare (S)-1-methyl-3-phenylpiperazine by enzymatic hydrolysis of the compound, followed by separation and cleavage of the oxalamic groups, whereby the protease of Streptomyces griseus is used as enzyme for the enzymatic hydrolysis.

专利号:US-2010137244-A1
优先权日:2006-07-13
标题 :Preparation and utility of hmg-coa reductase inhibitors
发明人：GANT THOMAS G; SARSHAR SEPEHR
权利人:AUSPEX PHARMACEUTICALS INC
摘要:Chemical syntheses and medical uses of novel modulators of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase and diastereomeric mixtures of isomers, individual diastereomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, the chemical synthesis thereof, and the medical use of such compounds for the treatment and/or management of hypercholesterolemia, dyslipidemia, coronary artery disease, atherosclerosis, metabolic syndrome, a hyperproliferative disease such as colorectal cancer, prostate cancer, and melanoma, a neurodegenerative disease such as cerebral ischemia, Alzheimer's disease, and Parkinson's disease are described.