CAS: 25952-53-8; 1-(3-Dimethylaminopropyl)-3-Ethylcarbodiimide Hydrochloride

相似化合物

1892-57-5 52198-63-7 25952-53-8

上下游产品

CAS号92-92-2 4-苯基苯甲酸 | CAS号81409-90-7 卡麦角林 | CAS号81409-91-8 N-[[[3-(dimethy... | CAS号32897-26-0 1-[3-(二甲氨基)丙基]-3-乙基脲 | CAS号1041005-85-9 N-ethyl-3-p-tol... | CAS号1041005-86-0 N1,N1-dimethyl-...

[3-(二甲基氨基)丙基]二硫代氨基甲酸置于sodium Hypochlorite,乙二胺四乙酸,氯甲酸乙酯,三乙胺体系中,用 二氯甲烷 用作溶剂,化学反应 4.0H,反应生成盐酸-N-乙基-N'-(3-二甲氨基丙基)碳二亚胺
参考文献:1-(3-二甲氨基丙基)-3-乙基碳二亚胺盐酸盐的 制备方法
标题:1-(3-二甲氨基丙基)-3-乙基碳二亚胺盐酸盐的 制备方法
摘要:本发明属于有机化工领域,具体涉及一种1‑(3‑二甲氨基丙基)‑3‑乙基碳二亚胺盐酸盐的制备方法.N,N'‑二甲基丙二胺和二硫化碳为原料于有机溶剂中反应,生成中间体1;中间体1与氯甲酸乙酯于有机溶剂中反应,三乙胺作为缚酸剂,制得中间体2;中间体2与乙胺于有机溶剂中反应,制得中间体3;中间体3中加入催化剂,用氧化剂进行一次氧化,得到粗品1‑(3‑二甲氨基丙基)‑3‑乙基碳二亚胺,萃取分离,即得中间体4;中间体4与盐酸盐进行盐交换反应制得产品1‑(3‑二甲氨基丙基)‑3‑乙基碳二亚胺盐酸盐.本发明具有较高的转化率,总收率较高,操作简单,适合工业化生产.

专利信息

专利号:WO-2021014395-A1
优先权日:2019-07-24
标题:Process for the synthesis of deuterated capsaicin, capsaicinoids and synthetic capsaicin analogs
发明人：ORUGANTI SRINIVAS; AMRUTAPU SRAVANTH KUMAR; SAMPATH MAGESH; SEN SAIKAT
权利人:DR REDDY’S INST OF LIFE SCIENCES
摘要:The present application provides novel processes for the synthesis of deuterated intermediates of capsaicinoids, particularly II, III, IV and V of capsaicinoids, relating to pharmaceutical applications. The invention also provides novel intermediates of compounds of formula IX, XIV, XV, XVI, XVII, XVIII, XX and XXI utilized in the process of making deuterated capsaicin II, III, IV and V.

专利号:US-7288661-B2
优先权日:2003-12-10
标 题 :Process for the synthesis of (2S,3aS,7aS)-1-[(S)-alanyl]-octahydro-1H-indole-2-carboxylic acid compounds and application in the synthesis of perindopril
发明人：DUBUFFET THIERRY; LECOUVE JEAN-PIERRE
权利人:SERVIER LAB
摘要:Process for the synthesis of compounds of formula (I): n nwherein R represents a hydrogen atom or a protecting group for the amino function.n n Application in the synthesis of perindopril and pharmaceutically acceptable salts thereof.

专利号:US-6376649-B1
优先权日:1998-12-18
标题 :Methods for the synthesis of α- hydroxy-β-amino acid and amide derivatives
发明人：SEMPLE JOSEPH E; LEVY ODILE E
权利人:CORVAS INT INC
摘要:Methods for the synthesis of alpha-hydroxy-beta-amino acid and amide derivatives and alpha-ketoamide derivatives and novel derivatives made by these methods are provided. These methods involve reacting a N-terminally blocked (protected) aminoaldehyde with an isonitrile and a carboxylic acid to give an amino-alpha-acyloxy carboxamide. The acyloxy group may be removed to give the derivative. Alternatively the protecting group is removed and acyl shift occurs to give the derivative. These derivatives are useful in the synthesis of compounds such as peptidyl alpha-ketoamides and alpha-hydroxy-beta-carboxylic acid and amide derivatives. Certain of these compounds have been reported to have activity as inhibitors of proteases, such as serine proteases and cysteine proteases.

专利号:US-2023339906-A1
优先权日:2020-09-26
标 题 :A process for the synthesis of anthranilic acid/amide compounds and intermediates thereof
发明人：SYTHANA SURESH KUMAR; NAGLE PRAMOD; KUMAR VIJAY KUMAR; KANAWADE SHRIKANT BHAUSAHEB; CHANDRE TUKARAM NIVRUTTI; THUBE VINAYAK KISAN; PATIL PRADEEP PRAKASH; SHUKLA SHALINI; SHENDE KANTILAL BALU; PATRA PRANAB KUMAR; KLAUSENER ALEXANDER G M
权利人:PI INDUSTRIES LTD; PI INDUSTRIES LTD
摘要:The present invention discloses a process for the synthesis of compound of formula (VII) or a salt thereof,wherein, R, R1, R2, R3, R4a and R4b are as defined in the detailed description. The process further comprises the synthesis of an anthranilic diamide compound of formula (I).

专利号:US-9809566-B2
优先权日:2012-09-06
标题:Organocatalytic process for asymmetric synthesis of decanolides
发明人：RAWAT VARUN; DEY SOUMEN; SHELKE ANIL MARUTI; SURYAVANSHI GURUNATH MALLAPPA; SUDALAI ARUMUGAM
权利人:COUNCIL SCIENT IND RES
摘要:The present invention discloses organocatalytic process for asymmetric synthesis of highly enantioselective decanolide compounds in high yield with >99% ee. Further, the present invention disclose cost effective, improved organocatalytic process for asymmetric synthesis of highly enantioselective decanolides compounds from non-chiral, cheap, easily available raw materials.

专利号:WO-2024013769-A1
优先权日:2022-07-12
标题:Process for solvent free continuous synthesis of amides and peptides
发明人：KULKARNI AMOL ARVINDRAO; ATAPALKAR RANJIT SHABU
权利人:COUNCIL SCIENT IND RES
摘要:The present invention relates to a novel process for the solvent free continuous synthesis of amides and peptides. More particularly, the invention relates to a process for synthesizing amides and peptides using coupling reagents where the process is done at room temperature with lower residence time and solvent free synthesis, producing enhanced yields and purity products.