CAS: 24083-13-4; 4-(Octyloxy)Benzaldehyde

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CAS号111-83-1 1-溴代正辛烷 | CAS号123-08-0 4-羟基苯甲醛; 对羟基苯甲醛 | CAS号629-27-6 1-碘辛烷 | CAS号67698-68-4 对辛烷氧基苯甲醇 | CAS号3386-35-4 对甲苯磺酸正辛酯 | CAS号96693-05-9 4-正辛氧基溴苯 | CAS号68-12-2 N,N-二甲基甲酰胺 | CAS号650606-14-7 2-(ethoxymethyl... | CAS号70262-80-5 N-(4-ethoxyphen... | CAS号67698-68-4 对辛烷氧基苯甲醇 | CAS号93206-95-2 2-[2-(4-°Ctoxyp... | CAS号55379-97-0 4-(辛氧基)肉桂酸 | CAS号61096-95-5 N-[(4-°Ctoxyphe... | CAS号41468-32-0 Benzenamine,4-m...

📜Ethyl 4-(octyloxy)Benzoate置于manganese(Iv) Oxide,红铝体系中,用 氯仿,甲苯 用作溶剂,化学反应 88.5H,反应生成4-辛氧基苯甲醛
参考文献:阳离子降冰片烷作为拟肽抗菌剂的合成与评价†
标题:阳离子降冰片烷作为拟肽抗菌剂的合成与评价†
摘要:已经合成了一系列结构两亲的双阳离子降冰片烷作为阳离子抗微生物肽的刚性,低分子量拟肽.将各种带电的亲水性官能团连接到降冰片烷骨架上,包括铵,胍,咪唑鎓和吡啶鎓部分.另外,通过缩醛键结合了一系列不同尺寸的疏水基团.评价化合物对革兰氏阴性和革兰氏阳性细菌的抗菌活性.在整个系列中都观测到了活动;其中最有效的药物对肺炎链球菌,粪肠球菌和几种金黄色葡萄球菌菌株的mic<=1μgml-1包括多重耐药性耐甲氧西林(mmrsa),中间糖肽(gisa)和中间万古霉素(visa)金黄色葡萄球菌.
Doi:10.1039/c5Ob00621J

专利信息

专利号:US-11365211-B2
优先权日:2018-02-01
标 题 :Stereoselective synthesis and process for the manufacturing of 2′-deoxynucleosides
发明人：ZHANG LIANHAO; VISHNUVAJJALA BABURAO; MORRIS JOEL; BAHDE ROBERT; DENYSENKO SERGIY M; LOPEZ OMAR DIEGO; WISHKA DONN GREGORY
权利人:THE USA AS REPRESENTED BY THE SEC DEP OF HEALTH AND HUMAN SERVICES; ALCHEM LABORATORIES CORP; US HEALTH
摘要:Methods for stereoselective synthesis and manufacturing of 2′-deoxynucleosides, such as 2′-ribonucleosides, are disclosed. In some embodiments, the 2′-deoxynucleoside is a β-anomer of a 2′-deoxynucleoside having a 3′ α hydroxyl, 4′ β hydroxymethyl configuration. Nonlimiting examples of compounds prepared by the disclosed methods include 4′-thio-2′-deoxycytidine (T-dCyd) and 5-aza-4′-thio-2′-deoxycytidine (5-aza-T-dCyd; aza-T-dCyd; aza-T-dC).

专利号:US-5012000-A
优先权日:1989-10-30
标 题 :Total synthesis of chiral 2-amino-1,3-diols
发明人：ILLIG CARL R; WEIS ALEXANDER L
权利人:EASTMAN KODAK CO
摘要:A method for the preparation of chiral 2-amino-1,3-diols is disclosed. The method involves four steps including performance of an aldol condensation with a chiral oxazolidinone on an aldehyde, treating the aldol condensation product with an alkali metal azide, treating the product with a borohydride reagent and reducing the azide to an amine.

专利号:US-2009131304-A1
优先权日:2005-02-28
标题 :Semi-Synthetic Desmethyl-Vancomycin-Based Glycopeptides With Antibiotic Activity
发明人：CHU DANIEL; LEI YAOHUI; BAI YU; NI ZHI-JIE; WANG JOHN JIAN-XIN
权利人:NOVARTIS VACCINES & DIAGNOSTIC
摘要:Semi-synthetic glycopeptides that have antibacterial activity are based on modifications of the desmethyl-vancomycin scaffold, in particular, acylation of the amino substituent on the amino-substituted sugar moiety on this scaffold with certain acyl groups; and/or conversion of the acid moiety on the macrocyclic ring of this scaffolds to certain substituted amides. In addition, compounds of the invention include desmethyl-vancomycin scaffolds on which the acid moiety on the macrocyclic ring is converted to certain substituted amides and the amino substituent on the amino-substituted sugar moiety is alkylated with certain alkyl groups. Also provided are methods for synthesis of the compounds, pharmaceutical compositions containing the compounds, and methods of use of the compounds for the treatment and/or prophylaxis of diseases, especially bacterial infections.

专利号:US-7696386-B2
优先权日:2006-09-29
标 题:Method of producing diol, polydiol, secondary alcohol or diketone compound
发明人：HOSONO HIDEO; BUCHAMMAGARI HARITHA; TODA YOSHITAKE; HIRANO MASAHIRO; OSAKADA KOHTARO; TAKEUCHI DAISUKE
权利人:JAPAN SCIENCE & TECH AGENCY
摘要:The invention is a process of using, as a reducing agent, a 12CaO.7Al 2 O 3 electride containing electrons in a number of 10 19 or more and 2.3×10 21 cm −3 or less in its cages to subject a carbonyl compound to reductive coupling in a solvent, thereby synthesizing a diol or polydiol. The invention is also a process of reducing a ketone compound in a solvent, thereby synthesizing a secondary alcohol or diketone compound. According to the process of the invention, it is possible to synthesize a diol or polydiol, or a secondary alcohol or diketone compound through simple operations in a short period without using an expensive and harmful metal hydride or metal salt nor limiting the atmosphere for the synthesis to an inert gas atmosphere as in conventional processes.

专利号:US-8558012-B2
优先权日:2009-03-02
标 题:2-fluoro-1,3-benzodithiol 1,1,3,3-tetraoxide derivative, production method thereof, and production method of monofluoromethyl group-containing compound using the same
发明人：SHIBATA NORIO
权利人:SHIBATA NORIO; NAGOYA INST TECHNOLOGY; TOSOH P TECH INC
摘要:A 2-fluoro-1,3-benzodithiol 1,1,3,3-tetraoxide derivative as a monofluoromethyl group introduction agent that is effective as an intermediate in pharmaceutical and agrochemical synthesis, a production method thereof, and a production method of a monofluoromethyl group-containing compound using this 2-fluoro-1,3-benzodithiol 1,1,3,3-tetraoxide derivative are provided. The 2-fluoro-1,3-benzodithiol 1,1,3,3-tetraoxide derivative represented by the following general formula (1) (wherein R 1 , R 2 , R 3 , and R 4 each independently represent a hydrogen atom, a straight-chain or branched alkyl group having 1 to 4 carbon atoms, a straight-chain or branched alkyloxy group having 1 to 4 carbon atoms, a halogen atom, a nitro group, or a cyano group), the production method thereof, and various monofluoromethyl group-containing compounds are manufactured using this 2-fluoro-1,3-benzodithiol 1,1,3,3-tetraoxide derivative as a monofluoromethylating agent.

专利号:WO-2019152459-A1
优先权日:2018-02-01
标 题 :Stereoselective synthesis and process for the manufacturing of 2'-deoxynucleosides