CAS: 23462-75-1; Dihydro-2H-Pyran-3(4H)-One

相似化合物

19752-84-2 61363-56-2 72886-97-6

上下游产品

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📜Alpha-酮戊二酸置于lithium Aluminium Tetrahydride,硫酸,Sodium Hydride,三氟乙酸体系中,用 四氢呋喃,甲醇,二氯甲烷,Mineral Oil 用作溶剂,化学反应 39.0H,反应生成四氢-2H-吡喃-3-酮
参考文献:二氢-2H-吡喃-3(4H)-One的合成
标题:二氢-2H-吡喃-3(4H)-One的合成
摘要:报道了合成 Dihydro-2H-Pyran-3(4H)-One 的实用合成程序.该方法从容易获得的β-酮戊二酸开始,并允许分四步以31%的总产率制备标题化合物.
Doi:10.3998/ark.5550190.0013.820

专利信息

专利号:US-9745281-B2
优先权日:2013-02-14
标 题 :Method for the synthesis of 4-(heterocycloalkyl)-benzene-1,3,-diol compounds
发明人：BOITEAU JEAN-GUY
权利人:GALDERMA RES & DEV
摘要:A method is described for the synthesis of 4-(heterocycloalkyl)-benzene-1,3-diol compounds of general formulae (I) and (II): n nwherein X can be an oxygen atom or a sulphur atom. Also described, is a method for the synthesis of the reactive intermediates of general formula (7a) or (7b)n n nNovel compounds as synthesis intermediates are also described.

专利号:US-5567830-A
优先权日:1994-02-14
标题 :Process for synthesis of acetylenic carbinols
发明人：UPASANI RAVINDRA B
权利人:COCENSYS INC
摘要:A method for the preparation of an acetylenic alcohol by reaction of 1,2-dibromoethylene with an alkyl, aryl an heteroaryl lithium in an inert solvent, followed by reaction with a carbonyl-containing compound to give an acetylenic alcohol is disclosed.

专利号:US-8487108-B2
优先权日:2005-11-14
标题 :Piperidinyl carbamate intermediates for the synthesis of aspartic protease inhibitors
发明人：BALDWIN JOHN J; CLAREMON DAVID A; TICE COLIN; CACATIAN SALVACION; DILLARD LAWRENCE W; ISHCHENKO ALEXEY V; YUAN JING; XU ZHENRONG; MCGEEHAN GERARD; SIMPSON ROBERT D; SINGH SURESH B; ZHAO WEI; FLAHERTY PATRICK T
权利人:BALDWIN JOHN J; CLAREMON DAVID A; TICE COLIN; CACATIAN SALVACION; DILLARD LAWRENCE W; ISHCHENKO ALEXEY V; YUAN JING; XU ZHENRONG; MCGEEHAN GERARD; SIMPSON ROBERT D; SINGH SURESH B; ZHAO WEI; FLAHERTY PATRICK T; VITAE PHARMACEUTICALS INC
摘要:The present invention is directed to aspartic protease inhibitors. Certain aspartic protease inhibitors of the invention can be represented by the following structural formula or a pharmaceutically acceptable salt thereof. The present invention is also directed to pharmaceutical compositions comprising the disclosed aspartic protease inhibitors. The present invention is further directed to methods of antagonizing one or more aspartic proteases in a subject in need thereof, and methods for treating an aspartic protease mediated disorder in a subject using the disclosed aspartic protease inhibitors.

专利号:US-9527855-B2
优先权日:2011-06-29
标题:Process for preparing chiral dipeptidyl peptidase-IV inhibitors
发明人：ZACUTO MICHAEL J; DUNN ROBERT F; MOMENT AARON J; JANEY JACOB M; LIEBERMAN DAVID; SHEEN FAYE; BREMEYER NADINE; SCOTT JEREMY; KUETHE JEFFREY T; TAN LUSHI; CHEN QINGHAO
权利人:MERCK SHARP & DOHME; MERCK SHARP & DOHME
摘要:A process for the preparation of pyrazolopyrolidines of structural formula I: n nand W isn n nor P, wherein in P is an amine protecting group. These compounds are useful in the synthesis of dipeptidyl peptidase-IV inhibitors for the treatment of Type 2 diabetes. Also provided are useful intermediates obtained from the process.

专利号:US-7902376-B2
优先权日:2008-01-23
标 题 :Process for preparing chiral dipeptidyl peptidase-IV inhibitor intermediates
发明人：XU FENG; KIM MARY M; KOHMURA YOSHINORI; SLADICKA TRICIA; ROSEN JONATHAN D; ZACUTO MICHAEL J
权利人:MERCK SHARP & DOHME; BANYU PHARMA CO LTD
摘要:A novel process is provided for the preparation of chiral trans-2,3-disubstituted 5-oxotetrahydropyrans of structural formula (I): n nwherein Ar is optionally substituted phenyl and P is a primary amine protecting group. These compounds are useful in the synthesis of dipeptidyl peptidase-IV inhibitors for the treatment of Type 2 diabetes. Also provided are useful intermediates obtained from the process.

专利号:US-2016185749-A1
优先权日:2013-02-14
标题:Method for the synthesis of 4-(heterocycloalkyl)-benzene-1,3,-diol compounds