CAS: 23249-97-0; 3-(1H-Benzo[d]Imidazol-2-yl)Propanoic Acid

相似化合物

2403-66-9 953061-74-0 6315-23-7

上下游产品

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📜3-(1H-Benzimidazol-2-yl)Propanal置于oxone体系中,用 N,N-二甲基甲酰胺 用作溶剂,化学反应 24.0H,反应生成丙考达唑
参考文献:功能化的原酸酯作为有效制备杂芳香族自行车的有力基石
标题:功能化的原酸酯作为有效制备杂芳香族自行车的有力基石
摘要:通过将取代的苯胺与官能化的原酸酯组合,已建立了一种高效且结缔的方法,用于制备苯并恶唑,苯并噻唑和苯并咪唑衍生物.这种方法的多功能性使得能够开发包含多功能位点的杂环新库.
Doi:10.1021/ol301472A

专利信息

专利号:US-2022118123-A1
优先权日:2019-02-22
标 题 :Combination of ar antagonists and targeted thorium conjugates
发明人：HAMMER STEFANIE; HAGEMANN URS BEAT; HAENDLER BERNARD; LEJEUNE PASCALE; ZITZMANN-KOLBE SABINE; SCHATZ CHRISTOPH; KARLSSON JENNY
权利人:BAYER AG; BAYER AS
摘要:The present invention covers combinations of at least two components, component A and component B, comprising component A being PSMA-TTC, and component B being an antiandrogen selected form AR antagonists such as from cyproterone acetate, bicalutamide, flutamide, nilutamide, enzalutamide, apalutamide, darolutamide or keto-darolutamide, or an AR degrader such as ARV-110, or an ARN-terminal domain binder such as EPI-506, or an antisense oligonucleotide that reduces AR expression such as EZN-4176 or AZD-5312, or an androgen synthesis inhibitor such as abiraterone, particularly abiraterone acetate, seviteronel, galeterone, orteronel or ketoconazole, or a dual AR antagonist and androgen synthesis inhibitor such as ODM-204. Another aspect of the present invention covers the use of such combinations as described herein for the preparation of a medicament for the treatment or prophylaxis of a disease, particularly for the treatment of a hyper-proliferative disease.

专利号:US-12054512-B2
优先权日:2017-11-10
标 题 :Sting modulator compounds, and methods of making and using
发明人：VYSKOCIL STEPAN; CIAVARRI JEFFREY; CULLIS COURTNEY; ENGLAND DYLAN BRADLEY; GOULD ALEXANDRA E; GREENSPAN PAUL; HU YONGBO; LANGSTON STEVEN; LI GANG; MIZUTANI HIROTAKE; OKANIWA MASANORI
权利人:TAKEDA PHARMACEUTICALS CO
摘要:The present disclosure provides STING modulators/agonists, and methods of synthesis and methods for using for the prophylaxis or treatment of cancer and other STING-related diseases.The present disclosure relates to a compound represented by the Formula (I):wherein each symbol is as defined in the description, or a pharmaceutically acceptable salt thereof.

专利号:US-12180188-B2
优先权日:2020-05-19
标题:Antifibrotic compounds and related methods
发明人：STEFANOVIC BRANKO; NEFZI ADEL
权利人:UNIV FLORIDA STATE RES FOUND; THE FLORIDA INTERNATIONAL UNIV BOARD OF TRUSTEES
摘要:This discloses that compounds of Formula 1 have antifibrotic properties. In particular, this discloses a pharmaceutical composition including one or more compounds of Formula 1 and methods of using compounds of Formula 1 in fibrosis treatment and inhibiting type 1 collagen synthesis.

专利号:US-7732436-B2
优先权日:2003-05-19
标 题 :Preparation of hymenialdisine derivatives and use thereof
发明人：TEPE JETZE J
权利人:UNIV MICHIGAN STATE
摘要:The synthesis and biological activity of indoloazepines and acid amine salts thereof which are structurally related to naturally-occurring hymenialdisine is disclosed. Naturally-occurring hymenialdisine obtained from the sponge is a potent inhibitor of production of cytokines interleukin-2 (IL-2) and tumor necrosis factor-α (TNF-α). The chemically-synthesized indoloazepines of the invention also inhibit production of IL-2 and TNF-α. The indoloazepines are useful for treating inflammatory diseases, particularly diseases associated with kinases NF-κB or GSK-3β activation or NF-κB activated gene expression products. The indoloazepines are useful for the treatment of cancer by the inhibition of kinases CHK1 and CHK2.

专利号:US-2023021879-A1
优先权日:2019-11-27
标 题:Synthesis of 3 -rna oligonucleotides

专利号:KR-20000067196-A
优先权日:1999-04-24
标 题:The synthesis of benzimidazole type antifungals and dantib acterial agents