CAS: 23031-32-5; 5-[2-(Tert-Butylamino)-1-Hydroxyethyl]Benzene-1,3-Diol,Sulfuric Acid

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3,5-dihydroxyacetophenone 2-bromo-1-(3,5-dihydroxyphenyl)ethan-1-one terbutaline 1-(3,5-dinitrophenyl)ethanone(S)-1-isopropylamino-3-(1-naphthyloxy)-2-propanol (R)-propranolol terbutaline (-)-Terbutaline

3,5-二羟基苯乙酮置于氢气,碘,Potassium Carbonate,二甲基亚砜体系中,用 四氢呋喃,乙醇,N,N-二甲基甲酰胺 用作溶剂,化学反应生成硫酸特布他林
参考文献:一种硫酸特布他林的合成方法
标题:一种硫酸特布他林的合成方法
摘要:本发明提供了一种硫酸特布他林的合成方法,具体合成路线为:以3,5‑二羟基苯乙酮为原料,经苄基保护,氧化,酯化,还原氨化,脱苄,最后与硫酸成盐得到硫酸特布他林.本发明提供的一种硫酸特布他林的制备方法,有益效果在于:1,采用二甲基亚砜(Dmso)替代剧毒品二氧化硒,避免使用高危试剂,安全高效;2,无溴化过程,对环境污染小;3,操作简便,反应条件温和,步骤短,成本低,更适合工业化生产.

专利信息

专利号:US-2025206743-A1
优先权日:2022-03-25
标 题:Tyk2 inhibitor synthesis and intermediates thereof
发明人：MASSE CRAIG E; PHADKE AVINASH S; LAWSON JON P; LEVY STUART; YANG XIAOWEI; WU GUISHENG; FAN SHUFENG
权利人:TAKEDA PHARMACEUTICALS CO
摘要:Described herein are methods of synthesis of a tyrosine-protein kinase 2 (TYK2) inhibitor and to intermediate compounds of the synthesis and methods of making the intermediates. Also provided are pharmaceutically acceptable compositions including compounds prepared by the synthetic method and methods of treating disorders using the same.

专利号:US-2023288116-A1
优先权日:2022-03-14
标 题:Large scale synthesis of pharmaceutical and biologic formulations using thin film freezing
发明人：OWENS III DONALD E; KOLENG JR JOHN J
权利人:TFF PHARMACEUTICALS INC
摘要:The invention encompasses methods for the large-scale (preferably under cGMP or cGLP standards) preparation of micron-sized or submicron-sized particles including pharmaceutical or biologic active agents. The systems and methods include a cryogenic cooling system including a novel shroud that enhances the cooling effects thereby reducing product loss and increasing product yields.

专利号:WO-2023178029-A1
优先权日:2022-03-14
标 题 :Large scale synthesis of pharmaceutical and biologic formulations using thin film freezing

专利号:US-2013030282-A1
优先权日:2011-07-18
标题:Synthesis and characterization of near ir fluorescent magnetic and non-magnetic albumin nanoparticles for biomedical applications
发明人：MARGEL SHLOMO; COHEN SARIT; SALKMON ENAV COREM; PELLACH MICHAL
权利人:UNIV BAR ILAN; MARGEL SHLOMO; COHEN SARIT; SALKMON ENAV COREM; PELLACH MICHAL
摘要:The present invention discloses Near Infrared (NIR) fluorescent albumin nanoparticles having a structure selected from a core structure or a core-shell structure. Also disclosed are a process of preparing these NIR fluorescent albumin nanoparticles, and a method of in vivo detection of pathologies, in particular cancer pathology, by using administering these NIR fluorescent albumin nanoparticles to a patient.

专利号:EP-4493873-A1
优先权日:2022-03-14
标题 :Large scale synthesis of pharmaceutical and biologic formulations using thin film freezing

专利号:CN-118922420-A
优先权日:2022-03-25
标题 :Synthesis of TYK2 inhibitors and their intermediates