CAS: 22346-75-4; 4-(Hydroxymethyl)Pyridine 1-Oxide

该化合物是一种有机化合物,其特点是具有氢氧化甲基组和N-Ox功能组的环状结构,其特征为:该化合物一般是固体或液体,取决于其纯度和具体条件;在水和酒精等极地溶剂中可溶解,这表明它由于存在氢氧甲基组而有能力参与氢联结;N-xymymyro,其功能有助于其再活动,使其有可能成为各种化学反应的候选体,包括氧化和核生殖器替代物;4-Pyridinem乙醇,1-Ox经常用于有机合成,并可作为悬浮体和化学协调的化学反应;其生物活动也值得注意,因为含有环的化合物因其不同药理特性而众所周知;在处理和储存时,应参考安全数据,因为任何化学物质,以确保适当的防范.

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CAS号586-95-8 4-吡啶甲醇 | CAS号586-95-8 4-吡啶甲醇 | CAS号71935-32-5 2-氰基-4-羟甲基吡啶

合成工艺路线路线简述

  • 合成目标产物 4-Pyridylcarbinol N-Oxide 主要起始原料 4-Pyridylcarbinol
  • (文献来源)合成步骤主要原料 4-Pyridylcarbinol
📜4-吡啶甲醇置于manganese Tetrakis(2,6-Dichlorophenyl)Porphyrin,Ammonium Acetate,双氧水体系中,用 二氯甲烷,乙腈 用作溶剂,化学反应 2.0H,以85%的收率获得4-吡啶甲醇n-氧化物
参考文献:Oxidation Of N-Heterocycles By H2O2 Catalyzed By A Mn-Porphyrin: An Easy Access To N-Oxides Under Mild Conditions
标题:Oxidation Of N-Heterocycles By H2O2 Catalyzed By A Mn-Porphyrin: An Easy Access To N-Oxides Under Mild Conditions
摘要:多种n-杂芳香化合物在过氧化氢作为供氧剂和少量锰卟啉催化作用下,高效转化为相应的n-氧化物,并具有非常好的化学选择性.本文讨论了该方法的应用范围和局限性.
Doi:10.1055/s-1997-1383

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专利信息


专利号:US-3753970-A
优先权日:1970-08-04
标题:Cyclopeptides derived from polymyxins and their preparation
发明人：BOUCHAUDON J; JOLLES G
权利人:RHONE POULENC SA
摘要:THE NEW CYCLOPEPTIDES OF THE FORMULA: DAB<(-DAB(-G)-Y-Z-DAB(-G)-DAB(-G)-THR-) IN WHICH Y-Z REPRESENTS AN AMINO ACID CHAIN SELECTED FROM D-LEU-THR,D-PHE-LEU, D-LEU-LEU AND D-LEU-ILEU, G REPRESENTS AN AMINO-PROTECTING RADICAL OF THE FORMULA: PY-CH(-R)-OOC- IN WHICH PY REPRESENTS PYRIDYL, PYRIDYL-N-OXIDE, OR PYRIDYL OR PYRIDYL-N-OXIDE CARRYING A METHYL SUBSTITUENT, R REPRESENTS HYDROGEN, ALKYL OF 1 TO THROUGH 5 CARBON ATOMS, OR PHENYL, AND DAB REPRESENTS A,Y-DIAMINOBUTYRIC AID, THE AMINO ACIDS HAVING THE L-CONFFIGURATION UNLESS OTHERWISE INDICATED, SAID CYCLOPEPTIDES CONTAINING ONLY A SINGLE FREE AMINO GROUP, ARE USEFUL INTERMEDIATES FOR THE SYNTHESIS OF SEMI-SYNTHETIC PRODUCTS DERIVED FROM POLYMYXINS.

专利号:US-7199105-B2
优先权日:2002-08-15
标 题:Lincomycin derivatives possessing antibacterial activity
发明人：LEWIS JASON G; PATEL DINESH V; ANANDAN SAMPATH KUMAR; GORDEEV MIKHAIL F
权利人:VICURON PHARM INC
摘要:Novel lincomycin derivatives are disclosed. These lincomycin derivatives exhibit antibacterial activity. As the compounds of the subject invention exhibit potent activities against bacteria, including gram positive organisms, they are useful antimicrobial agents. Methods of synthesis and of use of the compounds are also disclosed.

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合成参考文献


摘要:Jiao, N.; Li, Z., Science of Synthesis: Catalytic Oxidation in Organic Synthesis, (2017) 1, 703.
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