📜2,2'-亚甲基二[5-(二乙基氨基)苯酚]置于硫酸,Sodium Hydroxide,盐酸,Sodium Nitrite体系中,用 水 用作溶剂,以56%的收率获得派洛宁b 参考文献: 3,6-Disubstituted Xanthylium Salts[fr] Sels De Xanthylium Disubstitués En 3 Et 6 标题: 3,6-Disubstituted Xanthylium Salts[fr] Sels De Xanthylium Disubstitués En 3 Et 6
专利号:US-2018312534-A1 优先权日:2015-10-16 标题:Fluorescent anticancer platinum drugs 发明人:SARKAR ARINDAM; MANDAL SWADHIN KUMAR; SENGUPTA ANIRUDDHA; BISWAS GOUTAM; DUTTA PRADIP; SHARMA RUPALI; RAJ JUSTIN PAUL; SURYAVANSHI HEMANT; KUMARI SMITA 权利人:INVICTUS ONCOLOGY PVT LTD 摘要:The present disclosure is in relation to the field of nanotechnology and cancer therapeutics. In particular, the present disclosure relates to fluorescent platinum based compounds. The disclosure further relates to synthesis of said fluorescent platinum based compounds, nanoparticles and compositions comprising said fluorescent platinum based compounds/nanoparticles. The disclosure also relates to methods of managing cancer by the fluorescence changes between aforesaid platinum based compounds and corresponding free ligands, nanoparticles and compositions.
专利号:US-2023097824-A1 优先权日:2020-05-08 标 题:Semi-synthesis and use of racemic hematoxylin 发明人:DURRANT EDWARD E; HEINDL DIETER; HUBER FLORIAN MAURITIUS ERASUMU; KLEIN ERIC; KOSMEDER II JEROME W; VOSS EDGAR 权利人:VENTANA MED SYST INC; ROCHE DIAGNOSTICS OPERATIONS INC 摘要:A racemic hematoxylin formulation is disclosed that includes one or both of a stabilizer compound and an antioxidant. The disclosed composition exhibits sufficient stability to be utilized in an automated staining process. Methods of using and making the stabilized composition also are disclosed.
专利号:US-7888116-B2 优先权日:2004-07-22 标 题 :Uses of notch receptors, notch ligands, and notch modulators in methods related to metabolic diseases 发明人:EGAN JOSEPHINE M; DOYLE MAIRE E 权利人:US HEALTH 摘要:Disclosed are methods for identifying and isolating a precursor cell. Also, disclosed are methods of increasing insulin synthesis from a pancreatic B-cell. Further, disclosed are methods of improving pancreatic B-cell function. Still further, disclosed are methods of preventing or delaying the onset of a metabolic disease, methods of treating or preventing a metabolic disease in a subject, and to compositions for treating or preventing a metabolic disease in a subject in need of such treatment or prevention.
专利号:US-2005202459-A1 优先权日:2003-09-23 标 题 :Intercalation-mediated synthesis of polymers
专利号:US-9408848-B2 优先权日:2008-08-15 标 题 :Fluorescent CDK inhibitors for treatment of cancer 发明人:YENUGONDA VENKATA MAHIDHAR; BROWN MILTON L 权利人:YENUGONDA VENKATA MAHIDHAR; BROWN MILTON L; UNIV GEORGETOWN 摘要:Disclosed are molecules and their synthesis. The fluorescent moiety also facilitates screening, tracking, and pharmacodynamic studies of the drug in a biological system both in vitro and in vivo.
专利号:US-7368560-B2 优先权日:2003-09-23 标题:Intercalation-mediated synthesis of polymers 发明人:HUD NICHOLAS V 权利人:GEORGIA TECH RES INST 摘要:Methods and compositions for synthesizing biopolymers using an intercalator are provided. Aspects provide compositions and methods for synthesizing biopolymers with non-natural backbones or non-natural biopolymer subunits using natural biopolymer templates. Other aspects provide compositions and methods for synthesizing biopolymers using a template with a non-natural backbone on non-natural biopolymer subunits.
1: Zhang XF, Zhang J, Lu X. The Fluorescence Properties of Three Rhodamine Dye Analogues: Acridine Red, Pyronin Y and Pyronin B. J Fluoresc. 2015 Jul;25(4):1151-8. doi: 10.1007/s10895-015-1610-5. Epub 2015 Jul 11. doi: 10.1016/j.saa.2014.12.010. Epub 2014 Dec 16. doi: 10.1128/JVI.00839-14. Epub 2014 Aug 6. 4: Chen WX, Zhu HL, Xue M, Zhou H, Zhao F, Yan N, Chen Y. Quick staining technique for myeloperoxidase using potassium iodide and oxidized pyronine B. Acta Histochem. 2014 Jan;116(1):292-6. doi: 10.1016/j.acthis.2013.08.001. Epub 2013 Sep 14. doi: 10.1016/j.foodchem.2013.01.087. Epub 2013 Feb 8. doi: 10.1016/j.saa.2012.09.098. Epub 2012 Oct 12. doi: 10.1016/j.aca.2011.07.026. Epub 2011 Jul 23. doi: 10.1016/j.talanta.2011.06.053. Epub 2011 Jun 24. doi: 10.1039/c0dt01534b. Epub 2011 Mar 3. doi: 10.1002/cphc.200800776. doi: 10.1016/j.jcis.2008.12.058. Epub 2008 Dec 25. doi: 10.1093/jac/dkn407. Epub 2008 Sep 26. Chinese. Epub 2006 May 10.
合成参考文献
摘要:National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program., JAN1986 摘要:F, E. Ray and M. L. Jung. Brit. J. Cancer 5, 358 (1951). 参考文献:10.1038/s41467-021-24855-6 摘要:Miao Y, Qian N, Shi L, Hu F, Min W. 9-Cyanopyronin probe palette for super-multiplexed vibrational imaging. Nature Communications. 2021 Jul 26;12(1):4518. doi: 10.1038/s41467-021-24855-6.