CAS: 18641-57-1; Tribehenin

该化合物是来自多科萨酸(长链饱和脂肪酸)和甘油醇(三醇)的酯,这种化合物一般视温度而定,无色的黄色液体或固体色素,具有长的碳氢化合物链的特点,助长了其疏水特性,影响其熔点和沸点;甘油脊椎的存在允许乳化物形成,使其在各种应用中有用,包括化妆品和食品;其化学结构对氧化具有稳定性和阻力,增强其储存寿命;此外,由于润滑油和表面活性剂的配制能力,经常使用 docoanoic酸酯来减少表面紧张;安全数据表明,尽管普遍认为其毒性较低,但应对所有化学物质进行适当的处理和安全防范.

结构式图片

相似化合物

620-67-7 538-24-9 621-70-5

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CAS号94201-62-4 2-羟基丙烷-1,3-二基-二...

合成工艺路线路线简述

  • 合成目标产物 Tribehenin 主要起始原料 Docosanoic Acid And Glycerol
  • (文献来源)合成步骤主要原料 Docosanoic Acid 和 Glycerol
Alkaline Earth Salt Of/the/ Methylsulfuric Acid置于nickel Kieselguhr,氢气体系中,化学反应生成俞酸甘油酯
参考文献:Sudborough; Watson; Ayyar,Journal Of The Indian Institute Of Science,Section A,Vol. 9,P. 66
标题:Sudborough; Watson; Ayyar,Journal Of The Indian Institute Of Science,Section A,Vol. 9,P. 66

海关参考信息

专利信息


专利号:US-2018312463-A1
优先权日:2015-10-22
标题:Synthesis of Cyclohexane Carboxamide Derivatives Useful as Sensates in Consumer Products
发明人:YELM KENNETH EDWARD; WOS JOHN AUGUST; BUNKE GREGORY MARK; FREDERICK HEATH; HAUGHT JOHN CHRISTIAN; HOKE STEVEN HAMILTON; SREEKRISHNA KOTI TATACHAR; LIN YAKANG
权利人:PROCTER & GAMBLE
摘要:Synthesis methods to produce a series of carboxamides built off of an (S)-2-amino acid backbone or an (R)-2-amino acid backbone, depending upon the desired diastereomer of the end product.

专利号:US-11717498-B2
优先权日:2013-12-31
标题 :Methods of treatment using amphetamine controlled release, prodrug, and abuse deterrent dosage forms
发明人:POPP KARL; MECKLER HAROLD
权利人:Chemapotheca LLC; PHARMAPOTHECA A INC
摘要:The invention also relates to pharmaceutical compositions comprising highly pure amphetamine and amphetamine-class compounds resulting from the synthesis of chiral and racemic amphetamine derivatives by stereospecific, regioselective cuprate addition reaction with aziridine phosphoramidate compounds, and to methods of manufacturing, delivering, and using the amphetamine compounds resulting from the synthesis of chiral and racemic amphetamine derivatives by stereospecific, regioselective cuprate addition reaction with aziridine phosphoramidate compounds.

专利号:EP-2354120-A1
优先权日:2003-08-20
标题 :Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
发明人:GALLOP MARK A; YAO FENMEI; LUDWIKOW MARIA J; PHAN THU; PENG GE
权利人:XENOPORT INC
摘要:The present invention relates to acyloxyalkyl carbamate prodrugs of (±)-4-amino-3-(4-fluorophenyl)butanoic acid and analogs thereof, pharmaceutical compositions thereof, methods of making prodrugs of (±)-4-amino-3-(4-fluorophenyl)butanoic acid and analogs thereof, methods of using prodrugs of (±)-4-amino-3-(4-tluorophenyl)butanoic acid and analogs thereof, and pharmaceutical compositions thereof for treating or preventing common diseases and/or disorders such as spasticity and/or acid reflux disease. The present invention also relates to acyloxyalkyl carbamate prodrugs of (±)-4-amino-3-(4-fluorophenyl)butanoic acid and analogs thereof which are suitable for oral administration and to sustained release oral dosage forms thereof.

专利号:US-12208068-B2
优先权日:2013-12-31
标题:Amphetamine controlled release, prodrug, and abuse-deterrent dosage forms
发明人:POPP KARL; MECKLER HAROLD
权利人:PHARMAPOTHECA A INC
摘要:The invention also relates to processes for producing abuse deterrent pharmaceutical compositions comprising highly pure amphetamine and amphetamine-class compounds resulting from the synthesis of chiral and racemic amphetamine derivatives by stereospecific, regioselective cuprate addition reaction with aziridine phosphoramidate compounds, and to methods of manufacturing, delivering, and using the amphetamine compounds resulting from the synthesis of chiral and racemic amphetamine derivatives by stereospecific, regioselective cuprate addition reaction with aziridine phosphoramidate compounds.

专利号:US-2025213502-A1
优先权日:2016-02-24
标 题 :Amphetamine Controlled Release, Prodrug, and Abuse-deterrent Dosage Forms
发明人:POPP KARL; MECKLER HAROLD
权利人:PHARMAPOTHECA A INC
摘要:The invention also relates to pharmaceutical compositions comprising highly pure amphetamine and amphetamine-class compounds resulting from the synthesis of chiral and racemic amphetamine derivatives by stereospecific, regioselective cuprate addition reaction with aziridine phosphoramidate compounds, and to methods of manufacturing, delivering, and using the amphetamine compounds resulting from the synthesis of chiral and racemic amphetamine derivatives by stereospecific, regioselective cuprate addition reaction with aziridine phosphoramidate compounds.

专利号:US-5268181-A
优先权日:1989-04-13
标题 :Method of using niacin to control nocturnal cholesterol synthesis
发明人:O'NEILL VICTORIA A; EVENSTAD KENNETH L
权利人:UPSHER SMITH LAB INC
摘要:The invention provides a therapeutic method to treat hyperlipidemia by administering to a human patient a single daily dose of a prolonged release dosage form of niacin, so that nocturnal cholesterol synthesis is effectively suppressed.
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合成参考文献


参考文献:10.1111/j.2042-7158.2010.01225.x
摘要:Dhawan S, Kapil R, Singh B. Formulation development and systematic optimization of solid lipid nanoparticles of quercetin for improved brain delivery. J Pharm Pharmacol. 2011 Mar;63(3):342–51. doi: 10.1111/j.2042-7158.2010.01225.x.
参考文献:10.3109/02652048.2011.599442
摘要:Gao Y, Zhu C, Zhang X, Gan L, Gan Y. Lipid–polymer composite microspheres for colon-specific drug delivery prepared using an ultrasonic spray freeze-drying technique. Journal of Microencapsulation. 2011 Jul 18;28(6):549–56. doi: 10.3109/02652048.2011.599442.
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