合成目标产物 Tribehenin 主要起始原料 Docosanoic Acid And Glycerol
(文献来源)合成步骤主要原料 Docosanoic Acid 和 Glycerol
Alkaline Earth Salt Of/the/ Methylsulfuric Acid置于nickel Kieselguhr,氢气体系中,化学反应生成俞酸甘油酯 参考文献:Sudborough; Watson; Ayyar,Journal Of The Indian Institute Of Science,Section A,Vol. 9,P. 66 标题:Sudborough; Watson; Ayyar,Journal Of The Indian Institute Of Science,Section A,Vol. 9,P. 66
专利号:US-2018312463-A1 优先权日:2015-10-22 标题:Synthesis of Cyclohexane Carboxamide Derivatives Useful as Sensates in Consumer Products 发明人:YELM KENNETH EDWARD; WOS JOHN AUGUST; BUNKE GREGORY MARK; FREDERICK HEATH; HAUGHT JOHN CHRISTIAN; HOKE STEVEN HAMILTON; SREEKRISHNA KOTI TATACHAR; LIN YAKANG 权利人:PROCTER & GAMBLE 摘要:Synthesis methods to produce a series of carboxamides built off of an (S)-2-amino acid backbone or an (R)-2-amino acid backbone, depending upon the desired diastereomer of the end product.
专利号:US-11717498-B2 优先权日:2013-12-31 标题 :Methods of treatment using amphetamine controlled release, prodrug, and abuse deterrent dosage forms 发明人:POPP KARL; MECKLER HAROLD 权利人:Chemapotheca LLC; PHARMAPOTHECA A INC 摘要:The invention also relates to pharmaceutical compositions comprising highly pure amphetamine and amphetamine-class compounds resulting from the synthesis of chiral and racemic amphetamine derivatives by stereospecific, regioselective cuprate addition reaction with aziridine phosphoramidate compounds, and to methods of manufacturing, delivering, and using the amphetamine compounds resulting from the synthesis of chiral and racemic amphetamine derivatives by stereospecific, regioselective cuprate addition reaction with aziridine phosphoramidate compounds.
专利号:EP-2354120-A1 优先权日:2003-08-20 标题 :Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof 发明人:GALLOP MARK A; YAO FENMEI; LUDWIKOW MARIA J; PHAN THU; PENG GE 权利人:XENOPORT INC 摘要:The present invention relates to acyloxyalkyl carbamate prodrugs of (±)-4-amino-3-(4-fluorophenyl)butanoic acid and analogs thereof, pharmaceutical compositions thereof, methods of making prodrugs of (±)-4-amino-3-(4-fluorophenyl)butanoic acid and analogs thereof, methods of using prodrugs of (±)-4-amino-3-(4-tluorophenyl)butanoic acid and analogs thereof, and pharmaceutical compositions thereof for treating or preventing common diseases and/or disorders such as spasticity and/or acid reflux disease. The present invention also relates to acyloxyalkyl carbamate prodrugs of (±)-4-amino-3-(4-fluorophenyl)butanoic acid and analogs thereof which are suitable for oral administration and to sustained release oral dosage forms thereof.
专利号:US-12208068-B2 优先权日:2013-12-31 标题:Amphetamine controlled release, prodrug, and abuse-deterrent dosage forms 发明人:POPP KARL; MECKLER HAROLD 权利人:PHARMAPOTHECA A INC 摘要:The invention also relates to processes for producing abuse deterrent pharmaceutical compositions comprising highly pure amphetamine and amphetamine-class compounds resulting from the synthesis of chiral and racemic amphetamine derivatives by stereospecific, regioselective cuprate addition reaction with aziridine phosphoramidate compounds, and to methods of manufacturing, delivering, and using the amphetamine compounds resulting from the synthesis of chiral and racemic amphetamine derivatives by stereospecific, regioselective cuprate addition reaction with aziridine phosphoramidate compounds.
专利号:US-2025213502-A1 优先权日:2016-02-24 标 题 :Amphetamine Controlled Release, Prodrug, and Abuse-deterrent Dosage Forms 发明人:POPP KARL; MECKLER HAROLD 权利人:PHARMAPOTHECA A INC 摘要:The invention also relates to pharmaceutical compositions comprising highly pure amphetamine and amphetamine-class compounds resulting from the synthesis of chiral and racemic amphetamine derivatives by stereospecific, regioselective cuprate addition reaction with aziridine phosphoramidate compounds, and to methods of manufacturing, delivering, and using the amphetamine compounds resulting from the synthesis of chiral and racemic amphetamine derivatives by stereospecific, regioselective cuprate addition reaction with aziridine phosphoramidate compounds.
专利号:US-5268181-A 优先权日:1989-04-13 标题 :Method of using niacin to control nocturnal cholesterol synthesis 发明人:O'NEILL VICTORIA A; EVENSTAD KENNETH L 权利人:UPSHER SMITH LAB INC 摘要:The invention provides a therapeutic method to treat hyperlipidemia by administering to a human patient a single daily dose of a prolonged release dosage form of niacin, so that nocturnal cholesterol synthesis is effectively suppressed.
参考文献:10.1111/j.2042-7158.2010.01225.x 摘要:Dhawan S, Kapil R, Singh B. Formulation development and systematic optimization of solid lipid nanoparticles of quercetin for improved brain delivery. J Pharm Pharmacol. 2011 Mar;63(3):342–51. doi: 10.1111/j.2042-7158.2010.01225.x. 参考文献:10.3109/02652048.2011.599442 摘要:Gao Y, Zhu C, Zhang X, Gan L, Gan Y. Lipid–polymer composite microspheres for colon-specific drug delivery prepared using an ultrasonic spray freeze-drying technique. Journal of Microencapsulation. 2011 Jul 18;28(6):549–56. doi: 10.3109/02652048.2011.599442.