CAS: 1821-12-1; 4-Phenylbutanoic Acid

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CAS号3360-41-6 4-苯基-1-丁醇 | CAS号72064-43-8 tert-butyl-dime... | CAS号81631-80-3 trimethyl(4-phe... | CAS号313058-67-2 2-(3-phenylprop... | CAS号2243-53-0 4-苯基丁-3-烯酸 | CAS号6628-68-8 2-苯乙基丙二酸二乙酯 | CAS号82772-38-1 α-(trichloromet... | CAS号2051-95-8 3-苯甲酰丙酸 | CAS号92643-35-1 4-phenylbutylsu... | CAS号17424-49-6 7-phenylheptane... | CAS号105026-91-3 N-[(4-hydroxy-3... | CAS号10473-01-5 4-methoxybutylb... | CAS号67857-97-0 4-(2-硝基-苯基)-丁酸 | CAS号5600-62-4 4-(4-硝基苯基)丁酸 | CAS号1823-15-0 4-(3-Nitro-phen... | CAS号3243-42-3 3-(1-萘基)丙酸 | CAS号4830-93-7 1-氯-4-苯基丁烷 | CAS号56-55-3 苯并(a)蒽 | CAS号583-53-9 1,2-二溴苯 | CAS号1370290-52-0 4-(4-(3-ethoxy-...

4-苯丁酸甲酯置于乙醇,Sodium Hydroxide体系中,化学反应 0.67H,以94.4%的收率获得4-苯基丁酸
参考文献:一种苯基丁酸的纯化方法
标题:一种苯基丁酸的纯化方法
摘要:本发明公开了一种苯基丁酸的纯化方法.该纯化方法包括如下步骤:(1)在催化剂催化下,工业级苯基丁酸在醇类溶剂中进行反应,反应后的体系经处理得到4‑苯丁酸酯;(2)在碱性催化剂或酸性催化剂存在的条件下,4‑苯丁酸酯在溶剂中进行水解反应得到纯化的苯基丁酸,即实现对工业级苯基丁酸的纯化.本发明纯化方法,以市售的苯基丁酸工业品作为原料,首先制备4‑苯丁酸甲酯,然后再经水解,酸化得到高纯度的苯基丁酸,为高纯度苯丁酸钠的获得提供了原料.本发明纯化方法以醇(甲醇和乙醇)作为反应溶剂,较现有技术中苯基丁酸的合成方法,更加环保,绿色,经过两步常规的反应即实现对苯基丁酸的纯化,纯化后的苯基丁酸的纯度达到99.5%,单一杂质控制在0.13%以内.

专利信息

专利号:US-4288608-A
优先权日:1978-06-01
标题:Synthesis of anthracyclines
发明人：JOHNSON FRANCIS; KIM KYOUNG S
权利人:RESEARCH CORP
摘要:There is provided a novel method of synthesizing certain heterocyclic quinones. In particular there is provided a novel and regiospecific synthesis of 9-acetyl-6,11-dihydroxy-4-methoxy-7,8,9,10-tetrahydronaphthacene-5,12-quinone (7,9-dideoxydaunomycinone) which is known intermediate in the synthesis of daunomycinone. There is also provided a method of preparing analogs of 7,9-dideoxydaunomycinone which thus provide for the preparation of known and desired analogs of daunomycinone. Daunomycinone is a known compound which is an intermediate in the preparation of the clinically accepted naturally-occurring antitumor antibiotics daunomycin and its derivitive adriamycin.

专利号:US-9376461-B2
优先权日:2011-06-06
标 题:Non-enzymatic synthesis of O-acetyl-ADP-ribose and analogues thereof
发明人：KOPPETSCH KARSTEN; SZCZEPANKIEWICZ BRUCE G; PERNI ROBERT B
权利人:KOPPETSCH KARSTEN; SZCZEPANKIEWICZ BRUCE G; PERNI ROBERT B; GLAXOSMITHKLINE LLC
摘要:Provided herein is a simple, one-step, non-enzymatic synthesis of O-Acetyl-ADP-ribose (OAADPR) from NAD and sodium acetate in acetic acid. The extension of this reaction to other carboxylic acids, demonstrates that the reaction between NAD, and NAD analogs produces mixtures of the corresponding 2′- and 3′-carboxylic esters. Included are O-carboxyl-ADP-ribose compounds and corresponding methods of synthesis (e.g., O-propionyl-ADP-ribose, O-succinyl-ADP-ribose, O-malonyl-ADP-ribose), as well as non-adenosine nucleoside compounds.

专利号:US-4841045-A
优先权日:1985-03-12
标 题 :Synthesis of vinblastine and vincristine type compounds
发明人：KUEHNE MARTIN
权利人:UNIV VERMONT
摘要:A new process for the stereospecific synthesis of alkaloids of the vinblastine and vincristine type including the synthesis of vinblastine and vincristine as well novel alkaloids which are active as anti-tumor agents.

专利号:US-4897477-A
优先权日:1985-03-12
标题:Synthesis of vinblastine and vincristine type compounds
发明人：KUEHNE MARTIN
权利人:UNIV VERMONT
摘要:A new process for the stereospecific synthesis of alkaloids of the vinblastine and vincristine type including the synthesis of vinblastine and vincristine as well novel alkaloids which are active as anti-tumor agents.

专利号:US-2023286918-A1
优先权日:2020-07-02
标 题:Manufacturing process for 3,5-dichloropicolinonitrile for synthesis of vadadustat
发明人：JURKAUSKAS VALDAS; JUNG YOUNG CHUN; KWON TAESOO; KANNAN ARUNACHALAM; GONDI VIJAYA BHASKER
权利人:AKEBIA THERAPEUTICS INC
摘要:Disclosed herein are methods and processes of preparing vadadustat or a pharmaceutically acceptable salts thereof, and intermediates (e.g., a compound of Formula (I), (I-F), (II), or (IV), or a pharmaceutically acceptable salts thereof) useful for the synthesis of vadadustat.

专利号:US-8618281-B2
优先权日:2006-01-03
标 题 :Geometric synthesis of porphyrin rods
发明人：LINDSEY JONATHAN S; YU LIANHE; THAMYONGKIT PATCHANITA; BHISE ANIL D
权利人:LINDSEY JONATHAN S; YU LIANHE; THAMYONGKIT PATCHANITA; BHISE ANIL D; UNIV NORTH CAROLINA STATE
摘要:A method of making a compound of Formula I′ n ncomprises reacting a compound of the formula DLCHO, with a compound of the formulan n nto produce the compound of Formula I′. Methods of using the compounds are also described, particularly as intermediates for the synthesis of porphyrin rods, which porphyrin rods are in turn useful for (among other things) the production of molecular memory devices.