CAS: 17372-87-1; Eosin Y Disodium Salt

该化合物是属于Xanthene染料类的合成染料,主要用作细胞学和细胞学的生物污点,可以在显微镜下对细胞结构进行视觉化;Eosin的特点是其红色至粉色的动态,其特点是其红色至粉色色,其特点是其具有活力,其红色至粉色的颜色,其特点是其结合的双层结合系统,能够有效吸收光;染料在水和酒精中溶解,使其具有多种用途;Eosin经常与血氧素结合,用于染色协议,与血氧素结合,其中它提供了与蓝色核的对比,突出了细胞图谱和其他细胞组成部分;此外,eosin 展示荧光素特性,可用于荧光显微镜;重要的是,通过谨慎处理素,因为它在与皮肤或眼睛接触时会引起刺激;

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17372-87-1 17372-87-1 17372-87-1

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REACH注册ECHA物质ECHA物质化妆品禁用物质清单C&L通报REACH预注册

上下游产品

fluorescein free acid glycine L-alanin methyl viologen cation radical eosin y

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    专利信息


    专利号:WO-2024000920-A1
    优先权日:2022-06-28
    标题 :Method for preparing β-trifluoromethylenamine compound on basis of organic dye catalysis
    发明人：CHEN XIAOYUN; TANG YISONG; ZHANG XIAOTONG; HUANG MINGYANG; QI GUANGJIE; XIANG XINRAN
    权利人:UNIV JIANGSU SCIENCE & TECH
    摘要:Disclosed in the present invention is a method for preparing a β-trifluoromethylenamine compound on the basis of organic dye catalysis. The present invention belongs to the technical fields of the synthesis of medicines, pesticide products and material intermediates. The β-trifluoromethylenamine compound has a structure as represented by formula (I). The preparation method of the present invention comprises: under the irradiation of environment-friendly, green and economic visible light, using a catalytic amount of a commercial organic dye Na2-Eosin Y as a photocatalyst, using CF3SO2Na which is cheap, easily available, stable and simple and convenient to operate as a trifluoromethyl source, using Na2CO3 as an additive, and using tert-butyl hydroperoxide as an initiator. The reaction has mild conditions and is insensitive to air and water, and the operation is simple and convenient, the reaction efficiency is high, and the target product is easy to purify. In addition, the present invention has a a wide reaction substrate range and good functional group tolerance, and most of the target product compounds can be obtained with good to significant yields.

    专利号:CN-115636762-B
    优先权日:2022-08-29
    标 题:A method for organic dye-catalyzed synthesis of β-trifluoromethylenamine compounds

    专利号:CN-119528828-A
    优先权日:2024-11-22
    标题 :Synthesis method of methylation product of nitrogen heterocycle or oxygen heterocycle compound

    专利号:CN-115636762-A
    优先权日:2022-08-29
    标题:A kind of method of organic fuel catalytic synthesis β-trifluoromethyl enamine compound

    专利号:CN-115504942-A
    优先权日:2022-09-15
    标题 :Synthesis method of alkyl or acyl substituted benzothiazole derivative

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    主要参考文献


    1: Hamasaki M, Chang KHF, Nabeshima K, Tauchi-Nishi PS. Intraoperative Squash and Touch Preparation Cytology of Brain Lesions Stained with H+E and Diff-Quik™: A 20-Year Retrospective Analysis and Comparative Literature Review. Acta Cytol. 2018;62(1):44-53. doi: 10.1159/000480063. Epub 2017 Oct 5. Review. doi: 10.1016/j.bbapap.2017.06.002. Epub 2017 Jun 6. Review.
    3: Chen JM, Li Y, Xu J, Gong L, Wang LW, Liu WL, Liu J. Computer-aided prognosis on breast cancer with hematoxylin and eosin histopathology images: A review. Tumour Biol. 2017 Mar;39(3):1010428317694550. doi: 10.1177/1010428317694550. Review. doi: 10.1002/dc.23697. Epub 2017 Mar 1. Review. Review. doi: 10.17305/bjbms.2016.917. Review.
    7: Darragh TM. The LAST Project and the diagnostic bottom line. Cytopathology. 2015 Dec;26(6):343-5. doi: 10.1111/cyt.12299. Review. doi: 10.1016/j.anireprosci.2015.06.019. Epub 2015 Jun 26. Review. doi: 10.1016/j.cld.2015.01.003. Epub 2015 Mar 10. Review. doi: 10.1097/PAI.0000000000000120. Review. doi: 10.1016/j.exppara.2014.10.005. Epub 2014 Oct 13. Review. doi: 10.1039/c4cc00751d. Review. doi: 10.1177/1066896913517939. Epub 2014 Jan 9. Review. doi: 10.1007/s10151-011-0721-5. Epub 2011 Jul 16. Review. doi: 10.1097/PAS.0b013e3182237985. Review. doi: 10.1111/j.1524-4725.2011.02051.x. Epub 2011 Jun 2. Review. doi: 10.3109/10520295.2010.515491. Review. doi: 10.1186/1756-9966-29-5. Review.

    合成参考文献


    参考文献:10.1124/mol.119.115964
    摘要:Lee TD, Lee OW, Brimacombe KR, Chen L, Guha R, Lusvarghi S, Tebase BG, Klumpp-Thomas C, Robey RW, Ambudkar SV, Shen M, Gottesman MM, Hall MD. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular Pharmacology. 2019 Nov;96(5):629–40. doi: 10.1124/mol.119.115964.
    参考文献:10.1055/a-1918-4406
    摘要:Miyabe H, Yoshioka E, Takahashi H, Kubo A, Ohno M, Watanabe F, Shiono R, Miyazaki Y. N-Heterocyclic Carbene Catalyzed Cross Dehydrogenative Coupling of Aldehydes with Methanol: Combined Use of Eosin Y and Hexachloroethane. Synthesis. 2022 Sep 14;54(24):5520–8. doi: 10.1055/a-1918-4406.
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