CAS: 16640-68-9; 2-(Triphenylphosphoranylidene)Acetonitrile

相似化合物

2136-75-6 24720-64-7 1439-36-7

上下游产品

(cyanomethyl)triphenylphosphonium chloride (cyanomethyl)triphenylphosphonium bromide p-tolylcyanate Methylenetriphenylphosphorane triphenylphosphoranetriphenylphosphorane 4-chlor°Cinnamonitrile 3-(2'-chlorophenyl)-2-propenenitrile (E)-3-(3,4,5-trimethoxyphenyl)acrylonitrile

(氰基甲基)三苯基溴化膦置于sodium Hydride体系中,用 四氢呋喃 用作溶剂,化学反应 144.0H,以80%的收率获得(三苯基膦)乙腈
参考文献:金属化叶立德 [ph3P−c−cn]M (M=li,Na,K) 的分离:金属离子对结构和键合情况的影响
标题:金属化叶立德 [ph3P−c−cn]M (M=li,Na,K) 的分离:金属离子对结构和键合情况的影响
摘要:报道了以锂,钠和钾作为金属阳离子的氰基取代的金属化叶立德 [ph 3 P−c−cn]M ( 1-M ; M=li,Na,K) 的分离和结构表征.在固态下,大多数不同的聚集体可以根据金属和额外的路易斯碱来确定.钠 ( 1-Na ) 和钾 ( 1-K )的冠醚配合物表现出不同的结构,钠更喜欢与氮端配位,而钾以不寻常的η 2配位模式与两个中心碳原子结合.叶二化物的形成伴随着结构变化,导致更短的cc键和更长的cn键.这可能是由于碳原子上的自由电子对离域到 Cn 部分的反键轨道中,这一点已被红外光谱和计算研究证实.详细的密度泛函理论计算表明,由于共价性较高,锂化合物的结构和成键情况的变化最为明显.
Doi:10.1002/chem.201805421

专利信息

专利号:US-8779121-B2
优先权日:2012-10-12
标题:Process for the synthesis of 3-(2-bromo-4,5-dimethoxyphenyl)propanenitrile, and application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
发明人：CARRANZA MARIA DEL PILAR; GARCIA ARANDA MARIA ISABEL; GONZALEZ JOSÉ LORENZO; SANCHEZ FRÉDÉRIC
权利人:SERVIER LAB
摘要:Process for the synthesis of the compound of formula (I): n nApplication in the synthesis of ivabradine, addition salts thereof with a pharmaceutically acceptable acid and hydrates thereof.

专利号:US-7125986-B2
优先权日:1997-12-29
标题:Penicillanic acid derivative compounds and methods of making
发明人：BUYNAK JOHN D; RAO AKIREDDY SRINIVASA; DOPPALAPUDI VENKATA RAMANA
权利人:UNIV SOUTHERN METHODIST
摘要:Compounds of formula I: n nwherein R 1 , R 2 , R 3 , R 4 and n have any of the values defined in the specification, and their pharmaceutically acceptable salts, are useful for inhibiting β-lactamase enzymes, for enhancing the activity of β-lactam antibiotics, and for treating β-lactam resistant bacterial infections in a mammal. The invention also provides pharmaceutical compositions, processes for preparing compounds of formula I, and novel intermediates useful for the synthesis of compounds of formula I.

专利号:CA-2829428-A1
优先权日:2012-10-12
标题:Novel synthesis process for 3-(2-bromo-4.5-dimethoxyphenyl)propanenitrile, and application to the synthesis of ivabradine and of its additon salts to a pharmaceutically acceptableacid

专利号:MD-4335-C1
优先权日:2012-10-12
标 题 :The method of synthesis of 3- (2-bromo-4,5-dimethoxyphenyl) propannitrile and the method of synthesis of ivabradine and its salts, using it

专利号:US-2014107334-A1
优先权日:2012-10-12
标 题:Process for the synthesis of 3-(2-bromo-4,5-dimethoxyphenyl)propanenitrile, and application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid

专利号:CA-2829428-C
优先权日:2012-10-12
标题:Novel synthesis process for 3-(2-bromo-4.5-dimethoxyphenyl)propanenitrile, and application to the synthesis of ivabradine and of its additon salts to a pharmaceutically acceptableacid