专利号:US-2022395800-A1 优先权日:2019-11-04 标题:Device for automated synthesis of oligo- and polysaccharides 发明人:SEEBERGER PETER H; DANGLAD FLORES JOSE; LE MAI HOANG KIM; PARDO VARGAS ALONSO; SLETTEN ERIC; SALWICZEK MARIO 权利人:MAX PLANCK GESELLSCHAT ZU RFERDERUNG DER WSS E V; GlycoUniverse GmbH & Co KG&A 摘要:The present invention generally relates to automated synthesis technology, and more particularly, to a device and method for automated synthesis of oligo- and polysaccharides on a solid support. In particular the present invention relates to a device for automated synthesis of oligo- and polysaccharides on a solid support comprising a reaction vessel, a reagent storing component, a reagent delivery system, a cooling device for cooling reaction vessel, and a pre-cooling device for pre-cooling the reagents to be supplied.
专利号:US-2009311292-A1 优先权日:2006-09-14 标题:Process for synthesis and incorporation of nitric oxide donors in macromolecular compositions 发明人:PACHECO OGARI; MOREIRA ROBERTO; SEABRA AMEDEA; SOUZA GABRIELA; OLIVEIRA MARCELO 权利人:CRISTALIA PROD QUIMICOS FARM; UNIV ESTADUAL DE CAMPINASUNICA 摘要:The present invention describes a process for the synthesis of S-nitrosothiols and the subsequent incorporation of these compounds in hydrophilic macromolecular compositions. By the process described herein, the S-nitrosothiols are synthesized in a device (FIG. 2 ) in a first step from the S-nitrosation reaction of their respective precursor thiols (A), promoted by a mechanical action that puts the thiols in contact with the nitrous acid formed from nitrite anions in acidic medium (B), and in a second mechanical operation, the freshly formed S-nitrosothiols are incorporated in an application vehicle (C) based on hydrophilic macromolecular compositions that increases their thermal stability. Therefore, the process under consideration combine the pre-application synthesis of S-nitrosothiols with their subsequent incorporation in delivery vehicles, with provide a relative stabilization of the S-nitrosothiols for sufficient periods so that the formulations prepared by this process may be stored in a domestic refrigerator during its time of use in its several possible applications.
专利号:WO-2008031182-A1 优先权日:2006-09-14 标 题 :Process for synthesis and incorporation of nitric oxide donors in macromolecular compositions 发明人:PACHECO OGARI; MOREIRA ROBERTO; SEABRA AMEDEA; SOUZA GABRIELA; OLIVEIRA MARCELO 权利人:CRISTALIA PROD QUIMICOS FARM; UNICAMP; PACHECO OGARI; MOREIRA ROBERTO; SEABRA AMEDEA; SOUZA GABRIELA; OLIVEIRA MARCELO 摘要:The present invention describes a device and a process for extemporaneous synthesis and incorporation of a s-nitrosothiol in a hydrophilic macromolecular composition resulting in a. topical S-nitrosothiol pharmaceutical composition, said, device constituted by a reaction compartment (5) or (12) containing an acid aqueous solution; a storage compartment [(1)+ (3)] and. [(2) + (4)] or (11) containing a nitrosable thiol, or an acid salt of the nitrosable thiol, and a nitrite salt, both in the solid form, separated from each other or in a mixture; and a formulation compartment (6) or (13) containing a hydrophilic macramolecular composition, which may be either coupled to or uncoupled from the reaction compartment, and said device being used in a process that combine the extemporaneous synthesis of a S-nitrosothiol with the incorporation of the extemporaneously synthesized S- nitrosothiol in a hydrophilic macromolecular composition immediately prior to the topical application of the resulting composition to a patient.
专利号:US-2022389374-A1 优先权日:2021-05-06 标题:Use of functionalized and non-functionalized ecms, ecm fragments, peptides and bioactive components to create cell adhesive 3d printed objects 发明人:KAUR AMAN; HERNANDEZ VICTOR; NSIAH BARBARA; ARIAS ISABEL; ALVAREZ LUIS 权利人:LUNG BIOTECHNOLOGY PBC 摘要:Embodiments of this disclosure relate to bioinks and bioink compositions. These bioinks may be 3D printed into a hydrogel. The printed hydrogel may support primary cell and induced pluripotent stem cell attachment, proliferation, and spreading. Compounds in the bioink may be modified to incorporate chemical functionality, such as by chemical synthesis means. Incorporating chemical functionality may allow the incorporation of modified material as a component in the bioink. The modifications may allow chemical conjugation of a desired component. The desired component may maintain its cell interactive feature to aid in cell attachment and proliferation. Such incorporation may allow modulation of the bioprinted object's mechanical properties without interfering with cell adhesion.
专利号:US-2022387957-A1 优先权日:2019-11-04 标 题 :Microwave-assisted method for synthesis of oligo- and polysaccharides on solid phase
专利号:EP-4045182-A1 优先权日:2019-11-04 标 题:Microwave-assisted method for synthesis of oligo- and polysaccharides on solid phase
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