CAS: 15537-71-0; (S)-2-Acetamido-3-Mercapto-3-Methylbutanoic Acid

该化合物是细胞酸的一种衍生物,一种氨酸,在蛋白合成和细胞代谢中起着关键作用;该化合物具有乙酰组和与含有硫的细胞脊椎相连的两个二甲基组,这提高了其溶性与稳定性;其抗氧化特性有助于减少生物系统中的氧化性压力;乙酰胺组的存在也可能影响其生物利用率和代谢途径;N-acysteine-3-dime-DL-cysteine经常因其潜在的治疗应用,特别是在呼吸道疾病的情况下和作为诱变剂,受到研究;此外,由于它能够补充体内的通食素水平,它可能会对解毒过程产生影响;与许多含有硫化合物一样,它可能表现出一种特质的气味;总的来说,该化合物对于药物和生物化学研究具有独特性能和潜在健康效益.

结构式图片

相似化合物

2510-38-5 22146-59-4 17916-88-0

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号52-67-5 D-青霉胺 | CAS号2219-30-9 3-巯基-D-缬氨酸盐酸盐 | CAS号108-24-7 乙酸酐 | CAS号59-53-0 2-(乙酰氨基)-3-巯基-3-甲基丁酸 | CAS号79032-48-7 SNAP | CAS号52-67-5 D-青霉胺 | CAS号188849-81-2 Glyco-SNAP-1 | CAS号79032-48-7 SNAP | CAS号59-53-0 2-(乙酰氨基)-3-巯基-3-甲基丁酸

合成工艺路线路线简述

  • 合成目标产物 N-Acetyl-3-Mercapto-D-Valine 主要起始原料 D-Penicillamine
  • (文献来源)合成步骤主要原料 D-Penicillamine
📜3-巯基-D-缬氨酸盐酸盐 反应生成N-乙酰基-D-青霉胺
参考文献:N-酰基半胱氨酸.
标题:N-酰基半胱氨酸.
摘要:
Doi:10.1021/jm00309A057

海关参考信息

专利信息


专利号:US-2022395800-A1
优先权日:2019-11-04
标题:Device for automated synthesis of oligo- and polysaccharides
发明人:SEEBERGER PETER H; DANGLAD FLORES JOSE; LE MAI HOANG KIM; PARDO VARGAS ALONSO; SLETTEN ERIC; SALWICZEK MARIO
权利人:MAX PLANCK GESELLSCHAT ZU RFERDERUNG DER WSS E V; GlycoUniverse GmbH & Co KG&A
摘要:The present invention generally relates to automated synthesis technology, and more particularly, to a device and method for automated synthesis of oligo- and polysaccharides on a solid support. In particular the present invention relates to a device for automated synthesis of oligo- and polysaccharides on a solid support comprising a reaction vessel, a reagent storing component, a reagent delivery system, a cooling device for cooling reaction vessel, and a pre-cooling device for pre-cooling the reagents to be supplied.

专利号:US-2009311292-A1
优先权日:2006-09-14
标题:Process for synthesis and incorporation of nitric oxide donors in macromolecular compositions
发明人:PACHECO OGARI; MOREIRA ROBERTO; SEABRA AMEDEA; SOUZA GABRIELA; OLIVEIRA MARCELO
权利人:CRISTALIA PROD QUIMICOS FARM; UNIV ESTADUAL DE CAMPINASUNICA
摘要:The present invention describes a process for the synthesis of S-nitrosothiols and the subsequent incorporation of these compounds in hydrophilic macromolecular compositions. By the process described herein, the S-nitrosothiols are synthesized in a device (FIG. 2 ) in a first step from the S-nitrosation reaction of their respective precursor thiols (A), promoted by a mechanical action that puts the thiols in contact with the nitrous acid formed from nitrite anions in acidic medium (B), and in a second mechanical operation, the freshly formed S-nitrosothiols are incorporated in an application vehicle (C) based on hydrophilic macromolecular compositions that increases their thermal stability. Therefore, the process under consideration combine the pre-application synthesis of S-nitrosothiols with their subsequent incorporation in delivery vehicles, with provide a relative stabilization of the S-nitrosothiols for sufficient periods so that the formulations prepared by this process may be stored in a domestic refrigerator during its time of use in its several possible applications.

专利号:WO-2008031182-A1
优先权日:2006-09-14
标 题 :Process for synthesis and incorporation of nitric oxide donors in macromolecular compositions
发明人:PACHECO OGARI; MOREIRA ROBERTO; SEABRA AMEDEA; SOUZA GABRIELA; OLIVEIRA MARCELO
权利人:CRISTALIA PROD QUIMICOS FARM; UNICAMP; PACHECO OGARI; MOREIRA ROBERTO; SEABRA AMEDEA; SOUZA GABRIELA; OLIVEIRA MARCELO
摘要:The present invention describes a device and a process for extemporaneous synthesis and incorporation of a s-nitrosothiol in a hydrophilic macromolecular composition resulting in a. topical S-nitrosothiol pharmaceutical composition, said, device constituted by a reaction compartment (5) or (12) containing an acid aqueous solution; a storage compartment [(1)+ (3)] and. [(2) + (4)] or (11) containing a nitrosable thiol, or an acid salt of the nitrosable thiol, and a nitrite salt, both in the solid form, separated from each other or in a mixture; and a formulation compartment (6) or (13) containing a hydrophilic macramolecular composition, which may be either coupled to or uncoupled from the reaction compartment, and said device being used in a process that combine the extemporaneous synthesis of a S-nitrosothiol with the incorporation of the extemporaneously synthesized S- nitrosothiol in a hydrophilic macromolecular composition immediately prior to the topical application of the resulting composition to a patient.

专利号:US-2022389374-A1
优先权日:2021-05-06
标题:Use of functionalized and non-functionalized ecms, ecm fragments, peptides and bioactive components to create cell adhesive 3d printed objects
发明人:KAUR AMAN; HERNANDEZ VICTOR; NSIAH BARBARA; ARIAS ISABEL; ALVAREZ LUIS
权利人:LUNG BIOTECHNOLOGY PBC
摘要:Embodiments of this disclosure relate to bioinks and bioink compositions. These bioinks may be 3D printed into a hydrogel. The printed hydrogel may support primary cell and induced pluripotent stem cell attachment, proliferation, and spreading. Compounds in the bioink may be modified to incorporate chemical functionality, such as by chemical synthesis means. Incorporating chemical functionality may allow the incorporation of modified material as a component in the bioink. The modifications may allow chemical conjugation of a desired component. The desired component may maintain its cell interactive feature to aid in cell attachment and proliferation. Such incorporation may allow modulation of the bioprinted object's mechanical properties without interfering with cell adhesion.

专利号:US-2022387957-A1
优先权日:2019-11-04
标 题 :Microwave-assisted method for synthesis of oligo- and polysaccharides on solid phase

专利号:EP-4045182-A1
优先权日:2019-11-04
标 题:Microwave-assisted method for synthesis of oligo- and polysaccharides on solid phase

供应商参考报价(招募中)

品牌试剂参考报价(招募中)

📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

主要参考文献

[参考文献]: Abith Vattekkatte, Et Al. Inhibition Of A Multiproduct Terpene Synthase From Medicago Truncatula By 3-Bromoprenyl Diphosphates. Org Biomol Chem. 2015 Apr 28;13(16):4776-84.
[参考文献]: Alessandra Bendini, Et Al. Olive Oil Enriched In Lycopene From Tomato By-Product Through A Co-Milling Process. Int J Food Sci Nutr. 2015;66(4):371-7.
[参考文献]: Hua Ren, Et Al. Type Ii Anti-Cd20 Mab-Induced Lysosome Mediated Cell Death Is Mediated Through A Ceramide-Dependent Pathway. Biochem Biophys Res Commun. 2015 Feb 20;457(4):572-7.
[参考文献]: Inés Racamonde, Et Al. Fabric Phase Sorptive Extraction: A New Sorptive Microextraction Technique For The Determination Of Non-Steroidal Anti-Inflammatory Drugs From Environmental Water Samples. Anal Chim Acta. 2015 Mar 20:865:22-30.
[参考文献]: Manoj Kumar Gupta, Et Al. Determination Of Urinary Pah Metabolites Using Dllme Hyphenated To Injector Port Silylation And Gc-Ms-Ms. J Anal Toxicol. 2015 Jun;39(5):365-73.

合成参考文献


参考文献:10.1016/j.theriogenology.2016.11.026
摘要:Khan FA, Chenier TS, Murrant CL, Foster RA, Hewson J, Scholtz EL. Dose-dependent inhibition of uterine contractility by nitric oxide: A potential mechanism underlying persistent breeding-induced endometritis in the mare. Theriogenology. 2017 Mar 01;90():59–64. doi: 10.1016/j.theriogenology.2016.11.026.
摘要:Spoerke DG, Smolinske SC, Wruk KM, Rumack BH. Infrequently used antidotes: indications and availability. Vet Hum Toxicol. 1986 Feb;28(1):69–75.
参考文献:10.1128/jvi.71.3.2202-2210.1997
摘要:Lane TE, Paoletti AD, Buchmeier MJ. Disassociation between the in vitro and in vivo effects of nitric oxide on a neurotropic murine coronavirus. J Virol. 1997 Mar;71(3):2202–10. doi: 10.1128/jvi.71.3.2202-2210.1997.
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