CAS: 1496552-16-9; Sofosbuvir Impurity A

该化合物是一种用于治疗丙型肝炎的抗病毒药物. 这种杂质的特征和控制是确保活性药物成分的质量和安全,其结构识别和量化对于遵守法规和批量一致性至关重要. Sofosbuvir 杂质 A 的高纯度参考标准对于药物测试的分析方法开发,验证和杂质定性至关重要.适当的文献和定性支持遵守ICH 准则,确保API 制造业的严格质量控制.其可用性有助于保持严格的不洁性限值药典标准.

英文名称Sofosbuvir Impurity A
中文名称索氟布韦杂质50
IUPAC名称isopropyl ((R)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-D-alaninate
其它别名D-Alanine, N-[[p(R),2'R]-2'-Deoxy-2'-Fluoro-2'-Methyl-P-Phenyl-5'-Uridylyl]-, 1-Methylethyl Ester; Isopropyl ((R)-(((2R,3R,4R,5R)-5-(2,4-Dioxo-3,4-Dihydropyrimidin-1(2H)-yl)-4-Fluoro-3-Hydroxy-4-Methyltetrahydrofuran-2-yl)Methoxy)(Phenoxy)Phosphoryl)-D-Alaninate; Sofosbuvir Impurity A; Isopropyl ((R)-(((2R,3R,4R,5R)-5-(2,4-Dioxo-3,4-Dihydropyrimidin-1(2H)-yl)-4-Fluoro-3-Hydroxy-4-Methyltetrahydrofuran-2-yl)Methoxy)(Phenoxy)Phosphoryl)-D-Alanite; Sofosbuvir Impurity 15/isopropyl ((R)-(((2R,3R,4R,5R)-5-(2,4-Dioxo-3,4-Dihydropyrimidin-1(2H)-yl)-4-Fluoro-3-Hydroxy-4-Methyltetrahydrofuran-2-yl)Methoxy)(Phenoxy)Phosphoryl)-D-Alaninate; Isopropyl ((R)-(((2R,3R,4R,5R)-5-(2,4-Dioxo-3,4-Dihydropyrimidin-1(2H)-yl)-4-Fluoro-3-Hydroxy-4-Methyltetrahydrofuran-2-yl)Methoxy)(Phenoxy)Phosphoryl; D-Alanine, N-[[p(R),2'R]-2'-Deoxy-2'-Fluoro-2'-Methyl-P-Phenyl-5'-Uridylyl]-, 1-Methylethyl Esterd-Alanine, N-[[p(R),2'R]-2'-Deoxy-2'-Fluoro-2'-Methyl-P-Phenyl-5'-Uridylyl]-, 1-Methylethyl Ester
CAS编号1496552-16-9
MFCD编号:MFCD28386806
分子式:C22H29FN3O9P分子量:529.46
产品CID: 722260
产品分类Inhibitors/Agonists → Anti-infection → HCV

相似结构搜索
InChIKey: TTZHDVOVKQGIBA-KHFYHRBSSA-N
InChI=1S/C22H29FN3O9P/c1-13(2)33-19(29)14(3)25-36(31,35-15-8-6-5-7-9-15)32-12-16-18(28)22(4,23)20(34-16)26-11-10-17(27)24-21(26)30/h5-11,13-14,16,18,20,28H,12H2,1-4H3,(H,
计算化学: 氢键受体数11.0氢键供体数3.0可旋转键数11.0

物理性质

密度1.41±0.1 g/cm3(预测)
pKa:9.39±0.10(预测)
LogP:1
溶解性Soluble In DMSO
外观形态白色至黄色固体
储存条件储存在 -20°C
产品应用该化合物是SOFOSBURVIR的分泌器,在SOFOSTBUVIER 中充当杂质. SOFOSTBUVIR (PSI-7977)是HCV RNA复制的抑制剂,并显示出强大的抗丙型肝炎病毒活性.

上下游产品

2'-deoxy-2'-fluoro-2'-methyluridine (R)-2-((R)-(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphorylamino)propionic acid isopropyl ester (S)-2-[(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphorylamino]propionic acid isopropyl ester O-phenyl phosphorodichloridate