CAS: 935-42-2; (1-Phenylcyclopropyl)Methylamine

上下游产品

CAS号935-44-4 1-苯基-1-环丙基甲腈 | CAS号6120-96-3 1-苯基环丙烷羧酰胺 | CAS号140-29-4 苯乙腈 | CAS号106-93-4 1,2-二溴乙烷 | CAS号935-64-8 Cyclobutanol, 1...

📜苯乙腈置于lithium Aluminium Tetrahydride,Sodium Hydride体系中,用 四氢呋喃 作为反应溶剂,化学反应 51.0H,反应生成 1-苯基环丙甲胺
参考文献:有氧氧化伯胺和原位反应生成的胺与格鲁布斯催化剂从醛和铵盐中合成腈
标题:有氧氧化伯胺和原位反应生成的胺与格鲁布斯催化剂从醛和铵盐中合成腈
摘要:本文报道了格鲁布斯催化的伯胺的需氧氧化合成腈的路线.该反应可容纳多种底物,包括简单的伯胺,空间受阻的β,β-二取代胺,烯丙胺,苄胺和α-氨基酯.还指出了与各种官能团的反应相容性,特别是与烯烃,炔烃,卤素,酯,甲硅烷基醚和游离羟基的相容性.腈也是通过醛和nh 4 Oac原位反应生成的亚胺氧化合成的.
DOI:10.1002/adsc.202000663

专利信息

专利号:US-2012053165-A1
优先权日:2009-03-03
标 题:Novel Phenyl Imidazoles and Phenyl Triazoles As Gamma-Secretase Modulators
发明人：ALLEN MARTIN PATRICK; AM ENDE CHRISTOPHER WILLIAM; BRODNEY MICHAEL AARON; DOUNAY AMY BETH; JOHNSON DOUGLAS SCOTT; PETTERSSON MARTIN YOUNGJIN; SCHWARTZ JACOB BRADLEY; TRAN TUAN PHONG
权利人:ALLEN MARTIN PATRICK; AM ENDE CHRISTOPHER WILLIAM; BRODNEY MICHAEL AARON; DOUNAY AMY BETH; JOHNSON DOUGLAS SCOTT; PETTERSSON MARTIN YOUNGJIN; SCHWARTZ JACOB BRADLEY; TRAN TUAN PHONG; PFIZER
摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula (I) as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.