CAS: 92-66-0; 4-Bromobiphenyl

• 英文名称4-Bromobiphenyl
• 中文名称4-溴-1,1'-联苯
• IUPAC名称1-bromo-4-phenylbenzene
• 其它别名Biphenyl,4-bromo- (6CI,8CI); (4-Bromophenyl)benzene; 1-Bromo-4-phenylbenzene; 4-Biphenylbromide; 4-Biphenylyl bromide; 4-Bromo-1,1'-biphenyl; 4-Bromobiphenyl; 4-Bromodiphenyl; 4'-Bromobiphenyl; PBB 3; p-Biphenylyl bromide; p-Bromobiphenyl; p-Bromodiphenyl; p-Phenylbromobenzene; p-Phenylphenyl bromide
• CAS编号92-66-0
• MFCD编号:MFCD00000100
• EINECS号:202-176-6
• FDA UNII编号:OE77OKH5BL
• 分子式:C12H9Br
• 分子量:233.1035
• 产品CID: 1965320
• 产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

• 相似结构搜索
• InChIKey: PKJBWOWQJHHAHG-UHFFFAOYSA-N
• InChI=1S/C12H9Br/c13-12-8-6-11(7-9-12)10-4-2-1-3-5-10/h1-9H…
• 计算化学: 氢键受体数0.0氢键供体数0.0可旋转键数1.0

物理性质

• 熔点82-86°C
• 沸点310°C at 760 mmHg
• 闪点>100°C
• 密度0.9327
• PSA:0.0
• LogP:4.1161
• 折射率1.6565 (估算)
• 蒸汽压0.00 mmHg
• 溶解性Dioxane: Soluble1G/10 Ml, Clear, Colorless To Very Faintly Yellow
• 敏感性4-BROMOBIPHENYL may be sensitive to light. This compound can react with oxidizing materials. (NTP, 1992)
• 外观形态几乎白色至微蓝色结晶薄片状物
• 储存条件密封, 常温干燥保存
• 产品应用有机合成中间体.
• 性质描述无色片状结晶.熔点91.5-92°C(89.5-90°C),沸点310°C,闪点143°C,相对密度0.9327(25/4°C).溶于醇,醚,二硫化碳,苯,四氯化碳和丙酮,微溶于乙酸,不溶于水.有特殊气味.

MSDS等安全信息

• GHS象形图
• GHS符号GHS07 & GHS05 & GHS09;
  注释: Exclamation mark & Corrosion & Environment
• 危险类别急性毒性 类别4(经口)
  特定目标器官毒性 - 单次接触 类别3
  皮肤腐蚀/刺激 类别2
  严重眼损伤 类别1
  水生急性毒性 类别1
  水生慢性毒性 类别1
  急性毒性 类别4(吸入)
  急性毒性 类别4(经皮)
  皮肤腐蚀 类别1B
  严重眼刺激 类别2
• 警示词Danger(危险)
• 危险描述H302 |吞咽有害.
  H335 |可能引起呼吸道刺激.
  H315 |造成皮肤刺激.
  H318 |造成严重眼损伤.
  H400 |对水生生物毒性极大.
  H410 |对水生生物毒性极大并具有长期持续影响.
  H332 |吸入有害.
  H312 |皮肤接触有害.
  H314 |造成严重皮肤灼伤和眼损伤.
  H319 |造成严重眼刺激.
• 防范说明P261-P264-P270-P271-P273-P280-P302+P352-P304+P340-P330-P362+P364-P391-P405-P501
• 危险等级9
• UN编号3152.0
• 危险品标志Xi,N,Xn
• 包装等级Ⅲ
• 安全声明22-24/25-37/39-26-61-60-39
• 危险类别码36/37/38-50/53-41-37/38-22
• WGK Germany3

欧盟法规

上下游产品

合成工艺路线路线简述

• 合成目标产物 4-Bromobiphenyl 主要起始原料 4-Biphenylboronic Acid
• 591-50-4 + 5467-74-3 = 92-66-0
  反应条件:1.1 Reagents: Tripotassium Phosphate Catalysts: (Sp-4-3)-(Acetato-Ko)[(2S)-1-[[6-[2-(Hydroxy-Ko)Phenyl]-2-Pyridinyl-Kn]Methyl]-N... (Mcm-41 Supported) Solvents: O-Xylene,Water; 24 H,130 °C; Cooled
  标题:Homogeneous Versus Supported Onn Pincer-Type Gold And Palladium Complexes: Catalytic Activity
  作者:Del Pozo,Carolina; Debono,Nathalie; Corma,Avelino; Iglesias,Marta; Sanchez,Felix
  参考文献:Chemsuschem 日期:2009 卷标:2(7) 页码:650-657]
  
  591-50-4 + 5467-74-3 = 92-66-0
  反应条件:1.1 Reagents: Tripotassium Phosphate Catalysts: (Sp-4-3)-(Acetato-Ko)[2-[6-[(1-Pyrrolidinyl-Kn)Methyl]-2-Pyridinyl-Kn]Phenolato-... Solvents: O-Xylene,Water; 180 Min,130 °C; Cooled
  标题:New Pyridine Onn-Pincer Gold And Palladium Complexes: Synthesis,Characterization And Catalysis In Hydrogenation,Hydrosilylation And C-C Cross-Coupling Reactions
  作者:Debono,N.; Iglesias,M.; Sanchez,F.
  参考文献:Advanced Synthesis & Catalysis 日期:2007 卷标:349(16) 页码:2470-2476]
  
  98-80-6 + 589-87-7 = 92-66-0
  反应条件:1.1 Reagents: Potassium Tert-Butoxide Catalysts: Dispiro[dibenzo[d,F][1,3,2]Dioxaphosphepin-6,2′λ5-[1,3,5,2,4,6]Triazatriphosphor... (Palladium Complex With Dba Ligand) Solvents: Toluene,Tetrahydrofuran; 4 H,110 °C
  标题:Synthesis And Characterization Of A Palladium(0) Complex With Cyclophosphazene Bearing Two Diphenylphosphine Ligands And Application In Suzuki-Miyaura Cross-Coupling
  作者:Silva,Maria Das G. De O. E; Galuppo,Carolina; Tudisco,Barbara C.; Oliveira,Arnaldo G. De Junior; Barrionuevo,Manoel V. F.; Et Al
  参考文献:Inorganica Chimica Acta 日期:2018 卷标:482 页码:259-267]
  
  1591-31-7 = 92-66-0
  反应条件:1.1 Catalysts: Bis(1,5-Cyclooctadiene)Nickel,4,4′-Bis(1,1-Dimethylethyl)-2,2′-Bipyridine Solvents: 1,4-Dioxane; 10 Min,Rt1.2 Reagents: Tetrabutylammonium Bromide Solvents: Cyclopentyl Methyl Ether; 36 H,Rt
  标题:Preparation Of Halogenated Aromatic Hydrocarbons Catalyzed By Nickel Under Visible Light
  参考文献:China]
  
  98-80-6 + 17333-82-3 + 14874-70-5 = 92-66-0
  反应条件:1.1 Catalysts: 1908483-91-9 (Polystyrene-Supported) Solvents: Methanol; 3 H,25 °C
  标题:Polystyrene-Resin Supported N-Heterocyclic Carbene-Pd(Ii) Complex Based On Plant-Derived Theophylline: A Reusable And Effective Catalyst For The Suzuki-Miyaura Cross-Coupling Reaction Of Arenediazonium Tetrafluoroborate Salts With Arylboronic Acids
  作者:Mohammadi,Elmira; Movassagh,Barahman
  参考文献:Journal Of Organometallic Chemistry 日期:2016 卷标:822 页码:62-66]
  
  98-80-6 + 589-87-7 = 92-66-0
  反应条件:1.1 Reagents: Potassium Carbonate Catalysts: (Sp-4-2)-Dichloro[2-[2-(Hydroxyimino-Kn)-1-Phenylpropylidene]Hydrazinecarbothioa... Solvents: Water; 8 H,70 °C
  标题:Phosphine-Free Polystyrene-Supported Palladium(Ii) Complex As An Efficient Catalyst For The Heck And Suzuki Coupling Reactions In Water
  作者:Bakherad,Mohammad; Keivanloo,Ali; Amin,Amir H.; Jajarmi,Saeideh
  参考文献:Comptes Rendus Chimie 日期:2012 卷标:15(11-12) 页码:945-949]
  
  98-80-6 + 589-87-7 = 92-66-0
  反应条件:1.1 Reagents: Potassium Carbonate Catalysts: Palladium (Amphiphilic Carbon Sphere-Supported),Carbon Solvents: Water; 1 H,90 °C
  标题:Palladium Nanoparticles On Amphiphilic Carbon Spheres: A Green Catalyst For Suzuki-Miyaura Reaction
  作者:Putta,Chandra Babu; Ghosh,Sutapa
  参考文献:Advanced Synthesis & Catalysis 日期:2011 卷标:353(11-12) 页码:1889-1896]
  
  98-80-6 + 1122-91-4 = 92-66-0
  反应条件:1.1 Catalysts: Palladium Diacetate Solvents: Ethanol; 10 Min,Rt
  标题:Tamarindus Indica Seed Ash Extract For C-C Coupling Under Added Organics And Volatile Organic Solvent-Free Conditions: A Waste Repurposing Technique For Suzuki-Miyaura Reaction
  作者:Bhaskar,Boyapally; Raghavender,Matta; Ramesh Naidu,Bandameeda; Venkateswarlu,Katta; Kumar,K. Shiva
  参考文献:Environmental Science And Pollution Research 日期:2023 卷标:30(28) 页码:71430-71438]
  
  5467-74-3 = 92-66-0
  反应条件:1.1 Reagents: Sodium Bicarbonate Catalysts: Palladium Solvents: Water; 8 H,Rt
  标题:A Two-Dimensional Amide-Linked Covalent Organic Framework Anchored Pd Catalyst For Suzuki-Miyaura Coupling Reaction In The Aqueous Phase At Room Temperature
  作者:Wu,Shang; Ding,Ning; Jiang,Pengwei; Wu,Lan; Feng,Qiaoliang; Et Al
  参考文献:Tetrahedron Letters 日期:2020 卷标:61(51)]
  
  5122-94-1 = 92-66-0
  反应条件:1.1 Reagents: Divinylbenzene-4-Vinylpyridine Copolymer (Brominated Or Iodinated) Catalysts: Sodium Nitrite Solvents: Acetonitrile; 1 H,80 °C
  标题:Ipso-Bromination/iodination Of Arylboronic Acids: Poly(4-Vinylpyridine)-Br2/i2 Complexes As Safe And Efficient Reagents
  作者:Fu,Fang; Gurung,Laxman; Czaun,Miklos; Mathew,Thomas; Prakash,G. K. Surya
  参考文献:Tetrahedron Letters 日期:2019 卷标:60(38)]
  
  98-80-6 + 589-87-7 = 92-66-0
  反应条件:1.1 Reagents: Sodium Carbonate Catalysts: Poly[[2,2′-Biquinoline]-4,4′-Diylcarbonylimino(6-Carboxy-1,3-Phenylene)Methylene... (Palladium Complex) Solvents: N-Methyl-2-Pyrrolidone; 6 H,100 °C
  标题:Polymer Biquinolyl-Containing Complexes Of Pd(Ii) As Efficient Catalysts For Cyanation Of Aryl And Vinyl Halides With K4Fe(Cn)6
  作者:Nikitin,Oleg M.; Polyakova,Olga V.; Sazonov,Petr K.; Yakimansky,Alexander V.; Goikhman,Mikhail Ya.; Et Al
  参考文献:New Journal Of Chemistry 日期:2016 卷标:40(12) 页码:10465-10473]
  
  98-80-6 + 589-87-7 = 92-66-0
  反应条件:1.1 Reagents: Potassium Carbonate Catalysts: Palladium,Silver Solvents: Water; 10 H,80 °C
  标题:Fast Synthesis Of Ag-Pd@reduced Graphene Oxide Bimetallic Nanoparticles And Their Applications As Carbon-Carbon Coupling Catalysts
  作者:Chen,Mingxi; Zhang,Zhe; Li,Lingzhi; Liu,Yu; Wang,Wei; Et Al
  参考文献:Rsc Advances 日期:2014 卷标:4(58) 页码:30914-30922]
  
  591-50-4 + 5467-74-3 = 92-66-0
  反应条件:1.1 Reagents: Potassium Carbonate Catalysts: Palladium,Poly(Vinylpyrrolidone) Solvents: Ethanol,Water; 5 H,Rt
  标题:Microwave- And Ultrasound-Assisted Suzuki-Miyaura Cross-Coupling Reactions Catalyzed By Pd/pvp
  作者:De Souza,Andrea Luzia F.; Da Silva,Lucyane C.; Oliveira,Bianca L.; Antunes,O. A. C.
  参考文献:Tetrahedron Letters 日期:2008 卷标:49(24) 页码:3895-3898]
  
  14874-70-5 + 19262-78-3 = 92-66-0
  反应条件:1.1 Reagents: Potassium Bromide,Tetrabutylammonium Tribromide Catalysts: P-Toluenesulfonic Acid Solvents: Methanol; 1.5 H,15 °C
  标题:Photochemical Sandmeyer-Type Halogenation Of Arenediazonium Salts
  作者:Sivendran,Nardana; Belitz,Florian; Sowa Prendes,Daniel; Manu Martinez,Angel; Schmid,Rochus; Et Al
  参考文献:Chemistry - A European Journal 日期:2022 卷标:28(9)]
  
  106-37-6 + 54098-94-1 = 92-66-0
  反应条件:1.1 Reagents: Potassium Carbonate,Potassium Hydroxide Catalysts: Palladium Solvents: Ethanol,Water; 2.5 H,50 °C
  标题:Ionic Chitosan Schiff Bases Supported Pd(Ii) And Ru(Ii) Complexes; Production,Characterization,And Catalytic Performance In Suzuki Cross-Coupling Reactions
  作者:Alkabli,J.; Rizk,Moustafa A.; Elshaarawy,Reda F. M.; El-Sayed,W. N.
  参考文献:International Journal Of Biological Macromolecules 日期:2021 卷标:184 页码:454-462]
  
  98-80-6 + 589-87-7 = 92-66-0
  反应条件:1.1 Reagents: Potassium Carbonate Catalysts: (Sp-4-2)-Bis(Acetato-Ko)[3-Methyl-5-[[4-(Trimethoxysilyl)Butyl]Thio-Ks]-4H-1,2,4... (Silica-Coated Iron Oxide Nanoparticles-Supported) Solvents: Water; 2.5 H,50 °C
  标题:Synthesis And Characterization Of 4-Amtt-Pd(Ii) Complex Over Fe3O4@sio2 As Supported Nanocatalyst For Suzuki-Miyaura And Mizoroki-Heck Cross-Coupling Reactions In Water
  作者:Hajipour,Abdol R.; Kalantari Tarrari,Mina; Jajarmi,Saeideh
  参考文献:Applied Organometallic Chemistry 日期:2018 卷标:32(3)]
  
  5122-94-1 = 92-66-0
  反应条件:1.1 Reagents: N-Bromosuccinimide Catalysts: 1-(1,1-Dimethylethyl) (2S,4R)-4-Hydroxy-1,2-Pyrrolidinedicarboxylate (Mcm-41 Supported Copper Bromide Complex) Solvents: Acetonitrile; 12 H,80 °C
  标题:A Highly Efficient Heterogeneous Copper-Catalyzed Chlorodeboronation Of Arylboronic Acids Leading To Chlorinated Arenes
  作者:He,Wen; Zhang,Rongli; Cai,Mingzhong
  参考文献:Rsc Advances 日期:2017 卷标:7(2) 页码:764-770]
  
  98-80-6 + 106-37-6 = 92-66-0
  反应条件:1.1 Reagents: Potassium Carbonate Catalysts: Palladium,1,3,5-Triazine,2,4,6-Tris[4-(Bromomethyl)Phenyl]-,Polymer With 1,1′-Methyleneb... (Pd Complexes) Solvents: Dimethylformamide,Water; 3 H,100 °C
  标题:Shape-Controllable Formation Of Poly-Imidazolium Salts For Stable Palladium N-Heterocyclic Carbene Polymers
  作者:Zhao,Huaixia; Li,Liuyi; Wang,Yangxin; Wang,Ruihu
  参考文献:Scientific Reports 日期:2014 卷标:4]
  
  98-80-6 + 589-87-7 = 92-66-0
  反应条件:1.1 Reagents: Potassium Carbonate Catalysts: (Sp-4-3)-Dichloro[(2-Phenyldiazenecarbothioic Acid-Kn2) 2-Phenylhydrazide-Kn1]Pa... (Polystyrene Resin-Supported) Solvents: Water; 5 H,70 °C
  标题:A Dithizone-Functionalized Polystyrene Resin-Supported Pd(Ii) Complex As An Effective Catalyst For Suzuki,Heck,And Copper-Free Sonogashira Reactions Under Aerobic Conditions In Water
  作者:Bakherad,Mohammad; Jajarmi,Saeideh
  参考文献:Journal Of Molecular Catalysis A: Chemical 日期:2013 卷标:370 页码:152-159]
  
  98-80-6 + 1122-91-4 = 92-66-0
  反应条件:1.1 Reagents: Potassium Carbonate Catalysts: Palladium,1,3-Benzenedicarboxaldehyde,Polymer With 4,4′,4′′-(1,3,5-Triazine-2,4,6-Triyl)T... Solvents: P-Xylene; 2 H,150 °C
  标题:Linker Engineering Of 2D Imine Covalent Organic Frameworks For The Heterogeneous Palladium-Catalyzed Suzuki Coupling Reaction
  作者:Krishnaraj,Chidharth; Jena,Himanshu Sekhar; Rawat,Kuber Singh; Schmidt,Johannes; Leus,Karen; Et Al
  参考文献:Acs Applied Materials & Interfaces 日期:2022 卷标:14(45) 页码:50923-50931

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• ➥ 象形图和危险代码
• ➥ 防范代码详解
• ➥ 危险代码说明
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