CAS: 84348-39-0; (S)-1-Tert-Butyl 2-Methyl 4-Methylenepyrrolidine-1,2-Dicarboxylate

该化合物是一种手性丙烯衍生物,通常用作有机合成和制药研究的多用途中间体,其立体(2S)配置和功能化甲酸酯组体对于构建复杂的分子框架,特别是不对称合成中,具有价值.三丁基乙基和甲基酯保护组群增强了稳定性,同时允许有选择地取消保护以进一步衍生.这一化合物对于培养生物活性分子,包括消毒和三环化合物,特别有用.其明确界定的结构和高纯度确保合成应用的再生性,使需要准确控制立体化学学和再活性的研究者成为首选.

结构式图片

相似化合物

84348-41-4 84348-38-9 256488-01-4

物理性质

MSDS等安全信息

欧盟法规

C&L通报

上下游产品

CAS号1779-49-3 甲基三苯基溴化膦 | CAS号102195-80-2 N-B°C-4-氧-L-脯氨酸甲酯 | CAS号84348-38-9 N-B°C-4-亚甲基-L-脯氨酸 | CAS号74-88-4 碘甲烷 | CAS号75-24-1 三甲基铝 | CAS号593-71-5 氯碘甲烷 | CAS号19493-09-5 methylidene tri... | CAS号18107-18-1 (三甲硅烷)重氮甲烷 | CAS号27200-84-6 methyl tripheny... | CAS号186581-53-3 重氮甲烷 | CAS号84348-38-9 N-B°C-4-亚甲基-L-脯氨酸 | CAS号1129634-44-1 (S)-5-(叔丁氧羰基)-5... | CAS号1129634-43-0 (S)-5-叔丁基-6-甲基5... | CAS号84348-40-3 L-Proline, 4-me...

合成工艺路线路线简述

  • 1779-49-3 + 1145663-09-7 = 84348-39-0
    反应条件:1.1 Reagents: Dess-Martin Periodinane Solvents: Dichloromethane; 18 H,25 °C1.2 Reagents: Sodium Bicarbonate Solvents: Water1.3 Reagents: Potassium Tert-Butoxide Solvents: Tetrahydrofuran; 0.5 H,Rt1.4 Solvents: Tetrahydrofuran; Rt; 18 H,25 °C
    标题:Ni-Catalyzed Arylboration Of Unactivated Alkenes: Scope And Mechanistic Studies
    作者:Sardini,Stephen R.; Et Al
    参考文献:Journal Of The American Chemical Society 日期:2019 卷标:141(23) 页码:9391-9400]

    1145663-09-7 = 84348-39-0
    反应条件:1.1 Reagents: Dess-Martin Periodinane Solvents: Dichloromethane; 18 H,25 °C1.2 Reagents: Sodium Bicarbonate Solvents: Water2.1 Reagents: Potassium Tert-Butoxide Solvents: Tetrahydrofuran; 0.5 H,Rt2.2 Solvents: Tetrahydrofuran; Rt; 18 H,25 °C
    标题:Ni-Catalyzed Arylboration Of Unactivated Alkenes: Scope And Mechanistic Studies
    作者:Sardini,Stephen R.; Et Al
    参考文献:Journal Of The American Chemical Society 日期:2019 卷标:141(23) 页码:9391-9400]

    84348-38-9 = 84348-39-0
    反应条件:1.1 Reagents: 4-(Dimethylamino)Pyridine,1-Ethyl-3-(3′-Dimethylaminopropyl)Carbodiimide Hydrochloride
    标题:Development Of A Manufacturing Process For An Hcv Protease Inhibitor Candidate Molecule
    作者:Littler,Benjamin J.; Et Al
    参考文献:Organic Process Research & Development 日期:2015 卷标:19(1) 页码:270-283]

    84348-38-9 + 75-64-9 = 84348-39-0
    反应条件:1.1 Reagents: Citric Acid Solvents: Tert-Butyl Methyl Ether,Water; 1 H,Rt1.2 Reagents: 1-Ethyl-3-(3′-Dimethylaminopropyl)Carbodiimide Hydrochloride Catalysts: 4-(Dimethylamino)Pyridine Solvents: Tert-Butyl Methyl Ether; 1 H,20 °C
    标题:Development Of A Manufacturing Process For An Hcv Protease Inhibitor Candidate Molecule
    作者:Littler,Benjamin J.; Et Al
    参考文献:Organic Process Research & Development 日期:2015 卷标:19(1) 页码:270-283]

    102195-80-2 = 84348-39-0
    反应条件:1.1 Reagents: Titanocene Dichloride Solvents: Toluene; Rt; 3 D,Rt; Overnight,Rt1.2 Solvents: Tetrahydrofuran; 2 H,-78 °C; 1 D,Rt1.3 Solvents: Tetrahydrofuran; 15 Min,Rt; Rt -> -10 °C1.4 Reagents: Potassium Carbonate Solvents: Water; -10 °C
    标题:Synthesis Of A Novel Boc-Protected Cyclopropane-Modified Proline Analogue
    作者:Tymtsunik,Andriy V.; Et Al
    参考文献:Tetrahedron Letters 日期:2012 卷标:53(30) 页码:3847-3849]

    1779-49-3 + 84348-37-8 + 75-64-9 = 84348-39-0
    反应条件:1.1 Reagents: Potassium Tert-Butoxide Solvents: 2-Methyltetrahydrofuran,Tetrahydrofuran; 1 H,20 °C1.2 Solvents: N-Methyl-2-Pyrrolidone; 1 H,20 °C; 1 H,20 °C1.3 Reagents: Water; 15 Min,< 25 °C1.4 3 H,20 °C2.1 Reagents: Citric Acid Solvents: Tert-Butyl Methyl Ether,Water; 1 H,Rt2.2 Reagents: 1-Ethyl-3-(3′-Dimethylaminopropyl)Carbodiimide Hydrochloride Catalysts: 4-(Dimethylamino)Pyridine Solvents: Tert-Butyl Methyl Ether; 1 H,20 °C
    标题:Development Of A Manufacturing Process For An Hcv Protease Inhibitor Candidate Molecule
    作者:Littler,Benjamin J.; Et Al
    参考文献:Organic Process Research & Development 日期:2015 卷标:19(1) 页码:270-283]

    1779-49-3 + 84348-37-8 = 84348-39-0
    反应条件:1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran2.1 Reagents: 4-(Dimethylamino)Pyridine,1-Ethyl-3-(3′-Dimethylaminopropyl)Carbodiimide Hydrochloride
    标题:Development Of A Manufacturing Process For An Hcv Protease Inhibitor Candidate Molecule
    作者:Littler,Benjamin J.; Et Al
    参考文献:Organic Process Research & Development 日期:2015 卷标:19(1) 页码:270-283
📜Boc-4-氧代-L-脯氨酸甲酯置于亚甲基三苯基膦烷体系中,用 四氢呋喃,甲苯 作为反应溶剂,化学反应 3.08H,反应生成 N-Boc-4-亚甲基-L-脯氨酸甲酯
参考文献:Modulators Of 11-Beta Hydroxyl Steroid Dehydrogenase Type 1,Pharmaceutical Compositions Thereof,And Methods Of Using The Same
标题:Modulators Of 11-Beta Hydroxyl Steroid Dehydrogenase Type 1,Pharmaceutical Compositions Thereof,And Methods Of Using The Same
摘要:本发明涉及11-β羟基类固醇脱氢酶1型的抑制剂及其药物组合物.本发明的化合物可用于治疗与11-β羟基类固醇脱氢酶1型的表达或活性相关的各种疾病.

海关参考信息

专利信息


专利号:US-8927739-B2
优先权日:2011-05-18
标 题 :Processes for the preparation of 5-azaspiro[2.4]heptane-6-carboxylic acid and its derivatives
发明人：QIU YAO-LING; PENG XIAOWEN; KIM IN JONG; CAO HUI; TANG DATONG; OR YAT SUN; WANG GUOQIANG; XU GUOYOU
权利人:ENANTA PHARM INC
摘要:The present invention relates generally to an improved process for the preparation of 5-azaspiro[2.4]heptane-6-carboxylic acid and its derivatives which are useful intermediates in the synthesis of biologically active molecules, especially in the synthesis of hepatits C virus NS5A inhibitors. In particular, the present invention relates to processes and intermediates for the preparation of compounds of formulae (Ia), (Ib) and (Ic):

专利号:US-9718807-B2
优先权日:2012-06-05
标 题 :Synthesis of antiviral compound
发明人：SCOTT ROBERT WILLIAM; VITALE JUSTIN PHILIP; MATTHEWS KENNETH STANLEY; TERESK MARTIN GERALD; FORMELLA ALEXANDRA; EVANS JARED WAYNE
权利人:GILEAD PHARMASSET LLC
摘要:The present disclosure provides processes for the preparation of a compound of formula I: n nwhich is useful as an antiviral agent. The disclosure also provides compounds that are synthetic intermediates to compounds of formula I.

专利号:US-2024124938-A1
优先权日:2019-10-16
标题:Visual detection of pbd induced dna crosslinks
发明人：LACHAUD CHRISTOPHE; COMBES SÉBASTIEN; ABEL SÉBASTIEN; AUDOLY GILLES; BERRADA SARA
权利人:INST NAT SANTE RECH MED; INST JEAN PAOLI & IRENE CALMETTES; AIX MARSEILLE UNIV; CENTRE NAT RECH SCIENT
摘要:The present invention relates to the field of oncology. laboratory tools and methods, and especially anti-tumor DNA crosslinking agents. Most patients with advanced solid tumors develop resistance to chemotherapy due to the ability of cancer cells to repair or tolerate sustained DNA damages. The inventors showed that the compounds according to the present invention allow the detection and visualization of alkylated DNA damages induced by PBDs without altering their DNA crosslinking ability. This enables the study of the effect and properties of PBDs. In particular, the present invention relates new derivates of PBD molecules and their synthesis. The present invention also relates to a method for visualizing DNA crosslinking: to a method for assessing the resistance of a tumor to a crosslinking agent and to a method for identifying a molecule or treatment for improving the efficiency of a crosslinking agent.

专利号:BR-112018016418-B1
优先权日:2016-02-10
标 题:PYRROLOBENZODIAZEPINE CONJUGATE, COMPOSITION AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, METHOD OF SYNTHESIS OF SAID CONJUGATE AND USE THEREOF TO TREAT A PROLIFERATIVE DISEASE, AS WELL AS PYRROLOBENZODIAZEPINE COMPOUND

专利号:US-2015232453-A1
优先权日:2012-06-05
标 题 :Synthesis of antiviral compound

专利号:US-2016340345-A1
优先权日:2012-06-05
标题 :Synthesis of antiviral compound

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合成参考文献


参考文献:10.1055/s-0040-1707128
摘要:Sieber JD, Agrawal T. Recent Developments in C–C Bond Formation Using Catalytic Reductive Coupling Strategies. Synthesis. 2020 May 25;52(18):2623–38. doi: 10.1055/s-0040-1707128.
参考文献:10.1055/s-0034-1380333
摘要:Synthesis of an HCV Protease Inhibitor. Synfacts. 2015 Mar 18;11(04):0350. doi: 10.1055/s-0034-1380333.
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