CAS: 66346-83-6; 6-Chloropyridazine-3-Carboxamide
该化合物是一种该化合物是一种氯正丁烯核心,在3号位置上有一个碳boxamid功能组.这种结构使它成为有机合成的多用途中间体,特别是在研制药品和农用化学产品方面.氯替代物可增强回动性,从而能够产生有效的核生殖替代反应,而碳boxamide集团则提供了进一步衍生的机会.在标准条件下明确界定的化学特性和稳定性确保了合成应用的一贯性.这一化合物在药用化学中特别宝贵,有助于建造以丙烯津为基础的剑片,这些片片在生物活性分子中十分流行.高纯度和可靠的合成协议进一步有助于其在研究和工业环境中的效用.
相似化合物
871826-15-2 35857-89-7 1420961-44-9物理性质
MSDS等安全信息
上下游产品
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📜6-氯哒嗪-3-甲酸甲酯置于氨体系中,用 甲醇 作为反应溶剂,化学反应 0.5H,以97%的收率获得产物6-氯哒嗪-3-甲酰胺
参考文献:Konno,Shoetsu; Sagi,Mataichi; Siga,Futoshi,Heterocycles,1992,Vol. 34,# 2,P. 225-228
标题:Konno,Shoetsu; Sagi,Mataichi; Siga,Futoshi,Heterocycles,1992,Vol. 34,# 2,P. 225-228
海关参考信息
- 2912110000-甲醛
- 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:WO-0107416-A1
优先权日:1999-07-28
标题 :Method of producing pyridazine carboxylic acid derivatives
发明人：BESSARD YVES; CRETTAZ ROGER; EGGEL MICHAEL
权利人:LONZA AG; BESSARD YVES; CRETTAZ ROGER; EGGEL MICHAEL
摘要:The invention relates to a method of producing pyridazine carboxylic acid derivatives of the general formulae (Ia) or (Ib), wherein R<1> represents a group of the formula -OR<3> or -NR<4>R<5>, R<2> represents hydrogen, chlorine, a group of the formula -OR<6> or a group of the formula -NR<7>R<8>, R<3> represents C1-10 alkyl, C3-8 cycloalkyl or aryl-C1-4-alkyl, R<4> represents C1-10 alkyl, C3-8 cycloalkyl, optionally substituted aryl or aryl-C1-4-alkyl, R<5> represents hydrogen, C1-10 alkyl, C3-8 cycloalkyl, optionally substituted aryl or aryl-C1-4-alkyl and R<6> represents C1-10 alkyl, C3-8 cycloalkyl, aryl-C1-4-alkyl or an optionally substituted aromatic or heteroaromatic rest and R<7> and R<8> represent independently C1-10 alkyl, C3-8 cycloalkyl or aryl-C1-4-alkyl or together with the nitrogen atom form a saturated or aromatic heterocyclic ring. The inventive derivatives are obtained by reacting the corresponding 3-chloropyridazines or 3,6-dichloropyridazine with carbon monoxide and alcohols or amines H-R<1> in the presence of palladium-phosphin complexes and bases. The pyridazine carboxylic acid derivatives (Ia, Ib) are the intermediates for the synthesis of pharmaceutically active substances.
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
合成参考文献
摘要:Haider, N.; Holzer, W., Science of Synthesis, (2004) 16, 213.
📝 需求与反馈
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