CAS: 66176-39-4; 4-(Bromomethyl)Benzenesulfonyl Chloride

上下游产品

p-toluenesulfonyl chloride azobisisobutyronitrile 4-bromo-benzaldehyde phenylmethanethiol 4-bromomethyl-benzenesulfonamide 4-bromomethyl-benzenesulfonic acid methyl ester 4-(bromomethyl)benzenesulfonic acid 4-(bromomethyl)-N,N-diethylbenzenesulfonamide

对甲苯磺酰氯置于n-溴代丁二酰亚胺(Nbs)体系中,用 四氯化碳 作为反应溶剂,化学反应生成 4-溴甲基苯磺酰氯
参考文献:一系列新的选择性白三烯拮抗剂:探索和优化1,6-二取代的吲哚和吲唑的酸性区域.
标题:一系列新的选择性白三烯拮抗剂:探索和优化1,6-二取代的吲哚和吲唑的酸性区域.
摘要:对一系列由吲哚或吲唑衍生的白三烯拮抗剂1的羧酸区域进行系统的结构活性探索导致了一些发现.使用3-甲氧基对甲苯基片段(如酸1中所示)连接吲哚和酸性位点可提供最有效的羧酸1,四唑20和芳基磺酰亚胺21.芳基磺酰亚胺的含量是5-500倍以上(在体外和/或体内)比相应的羧酸更有效.在给定的体外活性水平下,邻甲苯基磺酰亚胺(如114)显示出比苯基磺酰亚胺更大的口服效力.酸性酮砜衍生物10(nu = Ch-(co2Ch3)so2Ph)模拟了磺酰亚胺的活性.
DOI:10.1021/jm00171A018

专利信息

专利号:US-2013203709-A1
优先权日:2010-08-09
标 题 :Acylsulfonamides and processes for producing the same
发明人：MANETSCH ROMAN; KULKARNI SAMEER; IYAMU IREDIA D; WANG HONG-GANG; DOI KENICHIRO; GUIDA WAYNE; SANTIAGO DANIEL; DU BOULAY COURTNEY
权利人:MANETSCH ROMAN; KULKARNI SAMEER; IYAMU IREDIA D; WANG HONG-GANG; DOI KENICHIRO; GUIDA WAYNE; SANTIAGO DANIEL; DU BOULAY COURTNEY; PENN STATE RES FOUND; UNIV SOUTH FLORIDA
摘要:The present disclosure relates to acylsulfonamides and processes for their preparation. The processes involve a target-guided synthesis approach, whereby a thioacid and a sulfonyl azide are reacted in the presence of a biological target protein, a Bcl-2 family protein, to form the acylsulfonamide.

专利号:US-2014315915-A1
优先权日:2009-02-09
标题:Design, synthesis and evaluation of procaspase activating compounds as personalized anti-cancer drugs

专利号:CN-117551005-A
优先权日:2022-08-05
标题 :A kind of synthesis method of 2-bromobenzenesulfonyl chloride and its derivatives

专利号:US-8524947-B2
优先权日:2008-02-22
标题 :Acylsulfonamides and processes for producing the same
发明人：WANG HONG-GANG; MANETSCH ROMAN; HU XIANGDONG; KULKARNI SAMEER; SUN JIAZHI
权利人:WANG HONG-GANG; MANETSCH ROMAN; HU XIANGDONG; KULKARNI SAMEER; SUN JIAZHI; UNIV SOUTH FLORIDA; H LEE MOFFITT CANCER CT & RES
摘要:The present disclosure relates to acylsulfonamides and processes for their preparation. The processes involve a target-guided synthesis approach, whereby a thioacid and a sulfonyl azide are reacted in the presence of a biological target protein, a Bcl-2 family protein, to form the acylsulfonamide.

专利号:US-9643960-B2
优先权日:2009-02-09
标 题:Procaspase activating compounds
发明人：HERGENROTHER PAUL J; PETERSON QUINN PATRICK; HSU DANNY CHUNG; WEST DIANA C; FAN TIMOTHY M; NOVOTNY CHRIS J
权利人:UNIV ILLINOIS
摘要:Compositions and methods are disclosed in embodiments relating to induction of cell death such as in cancer cells. Compounds and related methods for synthesis and use thereof, including the use of compounds in therapy for the treatment of cancer and selective induction of apoptosis in cells are disclosed. Compounds are disclosed that have lower neurotoxicity effects than other compounds.

专利号:US-2012040995-A1
优先权日:2009-02-09
标 题:Design, synthesis and evaluation of procaspase activating compounds as personalized anti-cancer drugs