专利号:US-8017323-B2 优先权日:2003-03-26 标 题 :Free reactant use in nucleic acid-templated synthesis 发明人:LIU DAVID R; SAKURAI KAORI 权利人:HARVARD COLLEGE 摘要:The present invention provides methods and compositions for expanding the scope of chemical reactions that can be performed during nucleic acid-templated organic syntheses. In particular, nucleic acid-templated chemistries are used to produce reaction intermediates attached to an oligonucleotide that can be used to identify the reaction intermediates and/or the resulting reaction products. The reaction intermediates then are reacted with free reactants (for example, reactants that are difficult or impractical to couple to an oligonucleotide) to produce a reaction product. This approach expands the scope of reagents useful in nucleic acid-templated syntheses to reagents that do not need to be or cannot be tethered to an oligonucleotide. The reagents, however, still permit the synthesis of reaction products attached to oligonucleotides that can be used to identify the reaction products.
专利号:US-7151112-B1 优先权日:2001-09-04 标题:Pharmaceutical uses and synthesis of nicotinamides 发明人:CUTSHALL NEIL S; JEFFREY SCOTT C 权利人:UCB SA 摘要:This invention is directed to methods of using a compound of the formula n nand pharmaceutically acceptable salts thereof, wherein n, X, R 1 and R 2 are disclosed herein, for treating inflammatory events in an animal subject.
专利号:US-2023295613-A1 优先权日:2020-02-14 标 题:Long chain carbon and cyclic amino acids substrates for genetic code reprogramming 发明人:JEWETT MICHAEL C; LEE JOONGOO; MOORE JEFFREY S; SCHWARZ KEVIN J 权利人:UNIV NORTHWESTERN; UNIV ILLINOIS 摘要:Abstract: Disclosed are methods, systems, components, and compositions for synthesis of sequence defined polymers. The methods, systems, components, and compositions may be utilized for incorporating novel substrates that include non-standard amino acid monomers and non-amino acid monomers into sequence defined polymers. As disclosed herein, the novel substrates may be utilized for acylation of tRNA via flexizyme catalyzed reactions. The tRNAs thus acylated with the novel substrates may be utilized in synthesis platforms for incorporating the novel substrates into a sequence defined polymer.
专利号:US-11814621-B2 优先权日:2018-06-01 标题 :Expanding the chemical substrates for genetic code reprogramming 发明人:JEWETT MICHAEL CHRISTOPHER; LEE JOONGOO; MOORE JEFFREY S; SCHWIETER KENNETH E; SCHWARZ KEVIN JEROME 权利人:UNIV NORTHWESTERN; UNIV ILLINOIS 摘要:Disclosed are methods, systems, components, and compositions for synthesis of sequence defined polymers. The methods, systems, components, and compositions may be utilized for incorporating novel substrates that include non-standard amino acid monomers and non-amino acid monomers into sequence defined polymers. As disclosed herein, the novel substrates may be utilized for acylation of tRNA via flexizyme catalyzed reactions. The tRNAs thus acylated with the novel substrates may be utilized in synthesis platforms for incorporating the novel substrates into a sequence defined polymer.
专利号:US-6072060-A 优先权日:1993-02-05 标题:Synthesis of taxol, taxol analogs and their intermediates with variable A-ring side chain structures and compositions thereof
专利号:EP-0348490-B1 优先权日:1988-01-11 标题 :Treatment of type 2 diabetes mellitus 发明人:COOPER GARTH JAMES SMITH; GREENE HOWARD E 权利人:AMYLIN PHARMACEUTICALS INC 摘要:Compounds and methods for blocking the effects of diabetes-associated peptide, or ''amylin'', a hormone found in the amyloid masses of Type 2 diabetics. Also disclosed are methods of identifying additional compounds having utility for the treatment of Type 2 diabetes. This putative hormone has been discovered to function both to inhibit insulin secretion and to inhibit glycogen synthesis. Regulation is accomplished by blocking the binding of amylin or amylin agonists, including calcitonin gene related peptide (CGRP), or biologically active sub-peptides thereof. Inhibitors include substituted peptides or sub-peptides of amylin or CGRP, cross-linked amylin and amylin agonists, synthetic amylin, anti-amylin receptor antibodies and anti-idiotype antibodies, and antibodies directed to amylin and amylin agonist active sites. Other antagonists include organic compounds which can be screened and assayed for anti-amylin effects by disclosed methods.
摘要:Monguchi, Y.; Sajiki, H., Science of Synthesis: Catalytic Reduction in Organic Synthesis, (2017) 2, 360. 参考文献:10.1023/a:1009225811420 摘要:Salah el Din AL, Braun V, Abdallah MA. Synthesis and activity of p-azidobenzoyloxyferricrocin, a photoactivatable analog of ferrichrome. Biometals. 1999 Jun;12(2):151–60. doi: 10.1023/a:1009225811420.