CAS: 6378-25-2; 2,4,5-Trichlorobenzenesulfonic Acid

上下游产品

1,2,4-Trichlorobenzene 2,4-Dichloroaniline m,p-dichloroaniline 2,4-dichlorophenol

📜三氯苯置于三氧化硫体系中,用 1,2-二氯乙烷 作为反应溶剂,化学反应 0.04H,以96.5%的收率获得产物2,4,5-三氯苯磺酸钠
参考文献:一种2,4,5-三氯苯磺酸的合成方法
标题:一种2,4,5-三氯苯磺酸的合成方法
摘要:本发明提供了一种2,4,5‑三氯苯磺酸的合成方法,包括以下步骤:将三氧化硫和1,2,4‑三氯苯分别加入至有机溶剂中,得到三氧化硫溶液和1,2,4‑三氯苯溶液;分别将三氧化硫溶液和1,2,4‑三氯苯溶液加入至微通道反应器中,发生磺化反应,将反应产物过滤后,洗涤,干燥即得2,4,5‑三氯苯磺酸.本发明的合成方法,利用微通道反应器进行反应,其可强化反应物的传质和传热效率,微米至毫米级反应通道尺寸可以实现磺化反应在短时间内的传质和传热效果,连续进料的方式使得产物可连续化合成,无放大效应,克服了现有技术中磺化剂三氧化硫过于活泼,易发生多磺化,氧化副反应,放热量大的安全风险问题,并且提高了反应收率.

专利信息

专利号:US-6087512-A
优先权日:1996-09-18
标题:Process for preparation of glycidyl ether
发明人：FURUKAWA YOSHIRO; KITAORI KAZUHIRO; YANAGIMOTO TETSUYA; MIKAMI MASAFUMI; YOSHIMOTO HIROSHI; OTERA JUNZO
权利人:DAISO CO LTD
摘要:A process for preparation of a glycidyl ether which is characrelized in reacting an epoxy compound of the formula ##STR1## wherein X is halogen or sulfonyloxy in the presence of a fluoride salt, with an alcohol. According to the above method, glycigyl ethers or their optically active compounds important as intermediates for synthesis of medicines are easily obtained in good yield and especially the optically active compounds are obtained with highly optical purity.

专利号:US-6057476-A
优先权日:1996-09-18
标题:Process for the preparation of 3-amino-2-hydroxy-1-propyl ethers
发明人：FURUKAWA YOSHIRO; KITAORI KAZUHIRO; MIKAMI MASAFUMI; YOSHIMOTO HIROSHI; OTERA JUNZO
权利人:DAISO CO LTD
摘要:A process for preparation of 3-amino-2-hydroxy-1-propyl ether of the formula ##STR1## wherein R 1 is substituted or unsubstituted alkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heterocyclic ring, R 2 and R 3 are the same or different hydrogen atom, a substituted or unsubstituted alkyl, or may form a ring together with an adjacent nitrogen atom, which ring may be interrupted with nitrogen atom, oxygen atom or sulfur atom, n which is characterized in reacting an epoxy compound of the formula ##STR2## wherein X is halogen, in the presence of a fluoride salt, with an alcohol and then reacting an amine. n According to the above method, an intermediates for synthesis of medicines is obtained in good yield and highly optical purity.

专利号:US-4143050-A
优先权日:1977-01-05
标题 :Manufacture of 3-halosulfonylthiophene-carboxylic acid compounds
发明人：ROSSY PHILLIP A; HOFFMANN WERNER; MUELLER NORBERT
权利人:BASF AG
摘要:3-Halosulfonylthiophene-carboxylic acid compounds are manufactured by reacting 3-ketothiophane-carboxylic acid compounds with sulfonic acid compounds, reacting the end product from the 1st reaction stage with alkali metal polysulfides, reacting the end product from the 2nd stage with a dehydrogenating agent and finally reacting the end product from the 3rd stage with halogen and water. The products are starting compounds for the manufacture of drugs, dyes and crop protection agents and have an anti-inflammatory, analgesic and anti-rheumatic action. In particular, the end products I are starting materials for the manufacture of sweeteners which are non-toxic and free from an after-taste, flavor-improving agents, diabetic aids and feedstuffs, and provide the means of a simple and economical synthesis of thiophene-saccharins.

专利号:US-4847115-A
优先权日:1987-08-10
标题:Chemical synthesis of conducting polypyrrole using uniform oxidant/dopant reagents
发明人：WARREN LESLIE F; STRAUSS DENNIS R
权利人:ROCKWELL INTERNATIONAL CORP
摘要:A method for producing oxidant/dopant reagent solutions which comprises reacting a basic ferric carboxylate, preferably basic ferric acetate, with an alkyl or aryl sulfonic acid, e.g., benzenesulfonic acid, to produce the corresponding ferric sulfonate in solution. Oxidant/dopant solutions can also be prepared containing cupric or ceric sulfonates. The oxidant/dopant solution is employed in situ for reaction with a pyrrole to produce electrically conductive polypyrrole. A porous substrate, such as fiberglass cloth, can be dipped in the oxidant/dopant solution, dried and then treated with a pyrrole to produce an electrically conductive polypyrrole deposit in the interstices of the substrate.

专利号:US-2021171437-A1
优先权日:2017-07-17
标题 :Peptide nucleic acid (pna) monomers with an orthogonally protected ester moiety and novel intermediates and methods related thereto
发明人：COULL JAMES M; GILDEA BRIAN D
权利人:VERA THERAPEUTICS INC
摘要:The present disclosure pertains to peptide nucleic acid (PNA) monomers and oligomers, as well as methods and compositions useful for the preparation of PNA monomer precursors (e.g. PNA Monomer Esters, Backbone Esters and Backbone Ester Acid Salts, as described below) that can be used to prepare PNA monomers wherein said PNA monomers can be used to prepare said PNA oligomers. In some embodiments, the disclosure features sulfonic acid salts of Backbone Ester compounds, which sulfonic acid salts generally tend to be crystalline and can be obtained in reasonably good yield, often without requiring any chromatographic purification of the reaction product of the Backbone Ester synthesis reaction. This disclosure also pertains to novel methods for the synthesis of said Backbone Ester compounds and novel methods for the formation of the related sulfonic acid salts. Exemplary ester groups include, but are not limited to, 2,2,2-trichloroethy-(TCE), 2,2,2-tribromoethyl-(TBE), 2-iodoethyl-groups (2-IE) and 2-bromoethyl-(2-BrE) as the ester group. These particular ester groups can be removed under conditions where both Boc and Fmoc protected amine groups are stable.

专利号:EP-2883866-A1
优先权日:2012-08-13
标题 :INTERMEDIATE FOR SYNTHESIS OF 1-(2-DEOXY-2-FLUORO-4-THIO-beta-D-ARABINOFURANOSYL) CYTOSINE, INTERMEDIATE FOR SYNTHESIS OF THIONUCLEOSIDE, AND METHODS FOR PRODUCING THESE INTERMEDIATES