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CAS号957-68-6 7-氨基头孢烷酸 | CAS号1453-82-3 异烟碱 | CAS号41128-84-1 α-Sulfobenzylce...

📜4-吡啶甲酰胺置于硫酸,碳酸氢钠,六甲基二硅氮烷体系中,用 二氯甲烷,水 作为反应溶剂,化学反应 5.0H,反应生成 头孢磺啶
参考文献:药用头孢磺啶钠化合物及其制备方法
标题:药用头孢磺啶钠化合物及其制备方法
摘要:本发明涉及医药技术领域,尤其涉及头孢磺啶钠化合物及其制备方法.药用头孢磺啶钠化合物的制备方法,该方法包括以下的步骤:1)3‑(4‑甲酰胺吡啶‑1‑亚甲基)‑7‑氨基‑头孢烷酸的制备;2)d‑磺苯乙酰氯的制备;3)d‑头孢磺烷酸的制备;4)头孢磺啶钠的制备.本发明解决现有的制备方法中存在成本高,安全性不足,得产低的技术缺陷,该方法用硅试剂法制备头孢磺啶钠化合物,消旋体可控,安全性较高,收益率较高且质量更好,起始原料易得,各步反应条件温和,设备要求低,所用溶剂单一,便于回收利用,能达到环保要求,适于规模化的工业生产.

专利信息

专利号:US-12123041-B2
优先权日:2018-09-21
标 题:Method for the production of amino sugar-containing products
发明人：MAERTENS JO; BAUWENS DAVID; VAN BELLEGEM WOUTER; COUSSEMENT PIETER; DUCHI DRIES; DE MEY MARJAN
权利人:UNIV GENT
摘要:A method or producing amino sugar (containing) products using metabolically engineered microorganisms is disclosed, wherein the conversion of UDP-N-acetylglucosamine to cell envelope precursors and molecules is reduced by altering the activity of enzymes involved in the synthesis of cell envelope precursors and molecules.

专利号:US-8017776-B2
优先权日:2003-07-15
标题 :Methods for synthesis of acyloxyalkyl compounds
发明人：BHAT LAXMINARAYAN; GALLOP MARK A
权利人:XENOPORT INC
摘要:Disclosed herein are methods for synthesizing 1-(acyloxy)-alkyl prodrug derivatives of drugs through oxidation of 1-acyl-alkyl derivatives of drugs under anhydrous reaction conditions. The methods typically proceed stereospecifically, in high yield, do not require the use of activated intermediates and/or toxic compounds and are readily amenable to scale-up.

专利号:US-4340672-A
优先权日:1979-09-19
标 题:Enzymatic synthesis of β-lactam antibacterials
发明人：KONDO EIJI; MITSUGI TAKASHI; FUJIWARA TAMIO; MUNEYUKI RYONOSUKE
权利人:SHIONOGI & CO
摘要:Penicillins and cephalosporins can be synthesized by the action of an acylase on a penicillin or cephalosporin nucleus amine as substrate and an ester (I) of the following formula as the acyl source: (I) (wherein RCO is an acyl group in penicillin or cephalosporin side chains; X is a hydrogen atom, lower alkyl group or hydroxy-lower alkyl group; Y is a hydrogen atom or a lower alkyl group; and n is a positive integer). The novel acyl source (I) is also disclosed.

专利号:US-8143437-B2
优先权日:2002-02-19
标题:Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof
发明人：GALLOP MARK A; XIANG JIA-NING; YAO FENMEI; BHAT LAXMINARAYAN; ZHOU CINDY X
权利人:GALLOP MARK A; XIANG JIA-NING; YAO FENMEI; BHAT LAXMINARAYAN; ZHOU CINDY X; XENOPORT INC
摘要:The present invention provides a method for synthesizing 1-(acyloxy)-alkyl derivatives from 1-acyl-alkyl derivatives, which typically proceeds stereospecifically, in high yield, does not require the use of activated intermediates and/or toxic compounds and is readily amendable to scale-up. The current invention also provides 1-acyl-alkyl derivatives of known drug components and methods for synthesizing these 1-acyl-alkyl derivatives.

专利号:US-2025228841-A1
优先权日:2024-01-12
标题 :Compositions affecting pigment production and methods for treatment of bacterial diseases
发明人：Lee Wai Yip Thomas; LO KAI YIP GEORGE
权利人:APTORUM THERAPEUTICS LTD
摘要:Provided herein are compounds, derivatives thereof, composition comprising one or more of said compounds and derivatives, and methods for prevention and/or treatment of microbial infections and/or related diseases or conditions. The present compounds and/or derivatives thereof can be represented by Formula (II):The present methods include administering to a subject an effective amount of one or more compounds of Formula (II). In one embodiment, said microbial infections are bacterial infections. More specifically, the bacterial infections are staphylococcal infections. Compositions are provided that include compounds of formula II in combination with one or more antibiotics or one or more staphyloxanthin-synthesis-inhibiting compounds.

专利号:US-2025002508-A1
优先权日:2020-05-05
标题 :Boronic acid derivatives and synthesis, polymorphic forms, and therapeutic uses thereof
发明人：HECKER SCOTT J; BOYER SERGE HENRI; BIO MATTHEW M; FANG YUANQING; GONZALES DE CASTRO ANGELA; LEFORT LAURENT; ZHU ZUOLIN; LINDER THOMAS
权利人:QPEX BIOPHARMA INC
摘要:Disclosed herein are antimicrobial compounds, polymorphic forms, compositions, pharmaceutical compositions, the method of use and preparation thereof. Some embodiments relate to boronic acid derivatives and their use as therapeutic agents, for example, β-lactamase inhibitors (BLIs).