CAS: 623-05-2; 4-Hydroxybenzyl Alcohol

上下游产品

Ethyl 4-hydroxybenzoate 4-benzyloxybenzyl alcohol 3,5-dibromo-4-hydroxybenzyl alcohol formaldehyd 4-hydroxybenzyl methyl ether 2,4,6-tris(hydroxymethyl)phenol 4-methyl-2,4'-methanediyl-di-phenol 2-(4-Hydroxy-benzyl)-6-salicyl-phenol

天麻素置于盐酸,β-D-Glucosidase体系中,用 水 作为反应溶剂,化学反应 2.0H,反应生成 对羟基苯甲醇
参考文献:Transformation Mechanisms Of Chemical Ingredients In Steaming Process Of Gastrodia Elata Blume
标题:Transformation Mechanisms Of Chemical Ingredients In Steaming Process Of Gastrodia Elata Blume
摘要:为了探究天麻中游离天麻和复合天麻在蒸煮前后的转化机制,采用中国药典(2015版)规定的传统蒸煮方法处理新鲜的天麻样品,并使用HPLC-Esi-Tof/ms方法鉴定蒸煮和新鲜天麻中的化学成分.最终,在天麻中鉴定出25种成分,基于这些化合物的特征片段,比较了新鲜和蒸煮天麻的25种成分的相对含量变化.首次进行了模拟天麻蒸煮过程的10种单体化合物的水解实验和酶解实验.结果表明,水解实验证明在天麻蒸煮过程中可以通过破坏酯键或醚键获得游离天麻或对羟基苯甲醇.酶解实验证明蒸煮在保护天麻方面起着重要作用,证实了蒸煮可以促进天麻化学成分的转化,抑制酶降解的假设.这个实验阐明了天麻传统蒸煮方法的科学机制,并为如何在一定程度上应用天麻煎剂提供了参考.
DOI:10.3390/molecules24173159

专利信息

专利号:US-2019292219-A1
优先权日:2018-03-26
标 题:Method of solid-state peptide synthesis using a novel polymeric support
发明人：JERABEK KAREL; HANKOVA LIBUSE; HOLUB LADISLAV; ZECCA MARCO; CENTOMO PAOLO; TROVO DANIELE; LEDER RICCARDO; BIONDI BARBARA
权利人:INST OF CHEMICAL PROCESS FUNDAMENTALS OF THE CAS V V I; UNIV DEGLI STUDI PADOVA
摘要:A method of solid-state synthesis of peptides that provides a polymeric solid-state synthesis support, attaches a first amino acid to said support to form the first amino acid molecule of the desired peptide chain, attaches additional amino acids to form the desired peptide chain, characterized in that the polymeric solid-state synthesis support is a styrenic polymer containing at least 50 mol % divinylbenzene monomer units, the styrenic polymer being functionalized with chloromethyl and/or benzyloxybenzyl alcohol and/or amino moieties, and having porosity 60-90% and medium pore diameter ranging from 10 to 80 nm. A functionalized styrenic polymer is claimed.

专利号:WO-9837078-A1
优先权日:1997-02-20
标题 :Solid phase and combinatorial synthesis of substituted thiophenes and of arrays of substituted thiophenes
发明人：DOERWALD FLORENCIO ZARAGOZA
权利人:NOVO NORDISK AS
摘要:A solid phase method for the synthesis of a plurality of differently substituted thiophenes with a wide variety of side-chain substituents as compounds of potential therapeutic interest. The thiophenes are prepared by reaction of a substrate-bound primary or secondary amine with a thiophosgene equivalent and reaction of the resulting intermediate with an acceptor-substituted acetonitrile in the presence of a base. Alkylation with an appropriate alkyl halide, followed by Thorpe-Ziegler-cyclization yields differently substituted, support-bound 3-aminothiophenes. These may be screened on the substrate or cleaved from the substrate and then screened in solution. Alternatively, the resin-bound 3-amino thiophenes or the synthetic intermediates can be subjected to further synthetic transformations (N-acylation, reduction) on the support, which permits the preparation of further therapeutically interesting compounds. The efficient synthesis of a wide variety of thiophenes using automated synthesis technology of the present method makes these compounds attractive candidates for the generation and rapid screening of diverse thiophene-based libraries. The method disclosed here provides an easy and fast access to highly diverse heterocyclic compounds of therapeutic interest, amenable to automatization.

专利号:US-8669356-B2
优先权日:2009-10-21
标 题 :Linker and support for solid phase synthesis of nucleic acid
发明人：HAYAKAWA YOSHIHIRO; TSUKAMOTO MASAKI; MORI KENJIRO; MINOMI KENJIRO; MAETA ERI; KONISHI TATSUYA
权利人:HAYAKAWA YOSHIHIRO; TSUKAMOTO MASAKI; MORI KENJIRO; MINOMI KENJIRO; MAETA ERI; KONISHI TATSUYA; NITTO DENKO CORP; UNIV NAGOYA NAT UNIV CORP
摘要:The invention provides a universal linker capable of synthesizing nucleic acid having a phosphate group at the 3′ terminal, a universal support carrying the linker, and a synthesis method of nucleic acid using the universal support. The linker for solid phase synthesis of nucleic acid contains a compound represented by at least one of the following formulae n nwherein each symbol is as defined in the specification.

专利号:US-9527800-B2
优先权日:2013-10-29
标 题:Process for total synthesis of venlafaxine
发明人：CHAVAN SUBHASH PRATAPRAO; PAWAR KAILASH PRALHAD
权利人:COUNCIL SCIENT IND RES
摘要:There is a need for short, resolution free asymmetric process for synthesis of one isomer of venlafaxine, (−)-venlafaxine. The invention provides a novel, short process of synthesis of (−)-venlafaxine, with yield greater than 50% and ee>99%. This process can be used for racemic synthesis of venlafaxine with overall yield 65%.

专利号:US-5512701-A
优先权日:1995-06-07
标题:Process for the synthesis of vinyl sulfenic acid derivatives
发明人：HOARD DAVID W; LUKE WAYNE D
权利人:LILLY CO ELI
摘要:The present invention is directed to a new process for the synthesis of vinyl sulfenic acid derivatives. These compounds are useful for the synthesis of benzo[b]thiophenes, in particular 2-aryl-benzo[b]thiophenes.

专利号:US-6723798-B1
优先权日:2000-08-28
标 题:Resins having vinyl ether linker for the solid phase organic synthesis
发明人：YOO SUNGEUN; GONG YOUNGDAE; SEO JINSOO
权利人:KOREAN RES INST OF CHEMICAL TE
摘要:The present invention relates to a resin having a vinyl ether linker and more particularly, to a resin having a vinyl ether linker expressed by formula (I), useful for the synthesis of compounds having hetero atoms such as alcohol, thiol, imidazole, triazole and tetrazole by employing combinatorial chemical synthesis on solid supports.