CAS: 57-64-7; Eserine Salicylate

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    专利号:US-9751877-B2
    优先权日:2012-09-21
    标题 :Substituted pyrido[1,2-a]pyrazines for the treatment of neurodegenerative and neurological disorders
    发明人:PETTERSSON MARTIN YOUNGJIN; JOHNSON DOUGLAS SCOTT; SUBRAMANYAM CHAKRAPANI; O'DONNELL CHRISTOPHER JOHN; AM ENDE CHRISTOPHER WILLIAM; GREEN MICHAEL ERIC; PATEL NANDINI CHATURBHAI; STIFF CORY MICHAEL; TRAN TUAN PHONG; KAUFFMAN GREGORY WAYNE; STEPAN ANTONIA FRIEDERIKE; VERHOEST PATRICK ROBERT
    权利人:PFIZER
    摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I n nas defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

    专利号:ES-2794012-T3
    优先权日:2008-10-27
    标题 :Intermediaries for the synthesis of mTOR kinase inhibitors

    专利号:RU-1767843-C
    优先权日:1990-06-15
    标题 :Method of synthesis of biologically active substance on the basis of n,n-dimethyl- (2-n',n'- dimethylaminomethylpyridyl-3)-carbamate salt and styrenevinylbenzene sulfocationite showing inhibition effect on choline esterases

    专利号:US-9550795-B2
    优先权日:2011-08-31
    标 题:Hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
    发明人:BRODNEY MICHAEL AARON; BUTLER CHRISTOPHER RYAN; HELAL CHRISTOPHER JOHN; O'NEILL BRIAN THOMAS
    权利人:BRODNEY MICHAEL AARON; BUTLER CHRISTOPHER RYAN; HELAL CHRISTOPHER JOHN; O'NEILL BRIAN THOMAS; PFIZER
    摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I, n nas defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

    专利号:US-9771379-B2
    优先权日:2015-09-24
    标题:N-(2-(2-amino-6-substituted-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]OXAZIN-8a(8H)-yl)-thiazol-4-yl) amides
    发明人:BRODNEY MICHAEL AARON; BUTLER CHRISTOPHER RYAN; ZHANG LEI; O'NEILL BRIAN THOMAS
    权利人:PFIZER
    摘要:The present invention is directed to compounds, tautomers and pharmaceutically acceptable salts of the compounds which are disclosed, wherein the compounds have the structure of Formula I, n nwherein the variables R 1 , R 2 , R 3 , R 4 and X are as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

    专利号:US-9403846-B2
    优先权日:2012-12-19
    标题:Carbocyclic- and heterocyclic-substituted hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
    发明人:BRODNEY MICHAEL AARON; O'NEILL BRIAN THOMAS; BUTLER CHRISTOPHER RYAN; LACHAPELLE ERIK ALPHIE
    权利人:PFIZER
    摘要:The present invention provides compounds of formula I, n nwherein the variables R 1 , R 2 , R 5 and b are as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

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    主要参考文献


    1: Ferreira J, Tkacz K, Turkiewicz IP, Santos I, Camoesas E Silva M, Lima A, Sousa I. Exploring the Bioactive Properties and Therapeutic Benefits of Pear Pomace. Antioxidants (Basel). 2024 Jun 28;13(7):784. doi: 10.3390/antiox13070784.
    2: Yakey B, Vohra V, Martin A, King AM. Treatment of pediatric antimuscarinic delirium with oral rivastigmine. Oxf Med Case Reports. 2023 Sep 25;2023(9):omad096. doi: 10.1093/omcr/omad096.
    3: Pinder N, Zimmermann JB, Gastine S, Würthwein G, Hempel G, Bruckner T, Hoppe- Tichy T, Weigand MA, Swoboda S. Continuous infusion of physostigmine in patients with perioperative septic shock: A pharmacokinetic/pharmacodynamic study with population pharmacokinetic modeling. Biomed Pharmacother. 2019 Oct;118:109318. doi: 10.1016/j.biopha.2019.109318. Epub 2019 Aug 6.

    合成参考文献


    摘要:Drug and Chemical Toxicology., 7(507), 1984 []
    摘要:Toxicology and Applied Pharmacology., 165(27), 2000 []
    摘要:Toxicology and Applied Pharmacology., 25(569), 1973 []
    摘要:U.S. Environmental Protection Agency. 1998. Extremely Hazardous Substances (EHS) Chemical Profiles and Emergency First Aid Guides. Washington, D.C.: U.S. Government Printing Office.
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