CAS: 546-06-5; Conessine
该化合物是来自genus Holarhena植物物种,特别是Holarhena抗菌菌体的藻类,其特点是分子结构复杂,包括四环框架,该化合物展示了一系列生物活动,包括潜在的抗炎,抗腹泻和抗微生物特性. (+)-Conessine因其在传统医学中的作用而闻名,特别是在治疗胃肠病方面.该物质通常以白到白的晶状粉的形式出现,在有机溶剂中溶解,但水溶解性有限.其立体化学作用很重要,因为(+)名称表明分子的具体光学活动,可影响其生物相互作用.与许多al-alhoidosials一样,(+)-Conessine的药理学影响对医药化学很有意义,而且持续的研究继续探索其潜在的治疗用途.安全和毒性简介是其使用中的基本考虑因素,特别是在草药方面.
- 英文名称Conessine
- 中文名称止泻木碱
- IUPAC名称(3S,3aS,5aS,5bR,9S,11aR,11bS,13aR)-N,N,2,3,11a-pentamethyl-2,3,3a,4,5,5a,5b,6,8,9,10,11,11a,11b,12,13-hexadecahydro-1H-naphtho[2',1':4,5]indeno[1,7a-c]pyrrol-9-amine
- 其它别名Con-5-enine,3b-(dimethylamino)- (8CI); Conessine (6CI); Conkurchine, N,18-dihydrotrimethyl- (7CI); 1H-Naphth[2',1'4,5]indeno[1,7a-c]pyrrole, con-5-enin-3-amine deriv.; (+)-Conessine; Conessin; Neriine; N',18-Dihydro-N,N,N'-trimethylconkurchine; Roquessine; Wrightine
- CAS编号546-06-5
- MFCD编号:MFCD00016752
- EINECS号:208-897-2
- FDA UNII编号:EZ38J9BBDF
- 分子式:C24H40N2分子量:356.59
- 产品CID: 2514688
- 同类组份化合物CAS546-06-5 (free base)5913-82-6 (HBr)
- 产品分类生物化工 → 提取物
物理性质
MSDS等安全信息
欧盟法规
ECHA物质C&L通报REACH预注册上下游产品
3β-dimethylamino-con-5-en-12-one formaldehydmethyl-((3S,3aS,5aS,5bR,9S,11aR,13aR)-2,3,11a-trimethyl-2,3,3a,4,5,5a,5b,6,8,9,10,11,11a,11b,12,13-hexadecahydro-1H-2-aza-pentalenol[1,6a-a]phenanthren-9-yl)-amine合成工艺路线路线简述
📜(1R,2S,6S,12S,13R,16S)-7-Hydroxy-N,N,6,13-Tetramethyl-7-Azapentacyclo[10.8.0.02,9.05,9.013,18]Icos-18-En-16-Amine 反应生成 止泻木碱
参考文献:Bhutani,K. K.;Vaid,R. M.;Ali,M.;Kapoor,R.;Soodan,S. R.;Kumar,D.,Phytochemistry,29,(1990) N,C. 969-972
标题:Bhutani,K. K.;Vaid,R. M.;Ali,M.;Kapoor,R.;Soodan,S. R.;Kumar,D.,Phytochemistry,29,(1990) N,C. 969-972
海关参考信息
- 2901210000-乙烯
2901220000-丙烯
2921199090-其他无环单胺 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-2010093823-A1
优先权日:2008-04-30
标 题 :Steroidal compounds as melanogenesis modifiers and uses thereof
发明人：ORLOW SETH J; KOMATSU LI NI
权利人:ORLOW SETH J; KOMATSU LI NI
摘要:A method for the identification of compounds) that control melanin synthesis (melanogenesis), and the preparation and use of such compounds, and compositions and formulations thereof to modify (e.g., inhibit) melanin production are disclosed. A representative compound of the invention is defined by formula I: n n n n n n n n n n The compounds may be prepared as pharmaceutical and cosmetic compositions, and in one embodiment, may be prepared in combination with each other, and with other melanogenesis inhibiting formulations. The compounds, compositions and formulations of the invention may be used for the prevention and treatment of conditions that are causally related to aberrant melanogenesis activity including, by way of non-limiting example, hyperpigmentation and others.
专利号:CN-109111391-A
优先权日:2018-07-03
标 题 :A kind of chiral pyrrolidine derivative containing three-membered ring skeleton and its synthesis method and application
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Kim H, Lee KI, Jang M, Namkoong S, Park R, Ju H, Choi I, Oh WK, Park J. Conessine Interferes with Oxidative Stress-Induced C2C12 Myoblast Cell Death through Inhibition of Autophagic Flux. PLoS One. 2016 Jun 3;11(6):e0157096. doi: 10.1371/journal.pone.0157096. eCollection 2016.
2: Morais-Silva G, Ferreira-Santos M, Marin MT. Conessine, an H3 receptor antagonist, alters behavioral and neurochemical effects of ethanol in mice. Behav Brain Res. 2016 May 15;305:100-7. doi: 10.1016/j.bbr.2016.02.025. Epub 2016 Feb 26. doi: 10.1089/mdr.2015.0194. Epub 2016 Jan 8. doi: 10.1186/1475-2875-12-194.
5: Siddiqui BS, Ali ST, Rizwani GH, Begum S, Tauseef S, Ahmad A. Antimicrobial activity of the methanolic bark extract of Holarrhena pubescens (Buch. Ham), its fractions and the pure compound conessine. Nat Prod Res. 2012;26(11):987-92. doi: 10.1080/14786419.2010.537268. Epub 2011 Aug 11. doi: 10.1021/jm8003625. Epub 2008 Aug 7. Epub 2007 Oct 6.
合成参考文献
参考文献:10.1186/1471-2210-8-9
摘要:Baker JG. Antagonist affinity measurements at the Gi-coupled human histamine H3 receptor expressed in CHO cells. BMC Pharmacol. 2008 Jun 06;8():9.
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