CAS: 533-37-9; 6,7-Dihydro-5H-Cyclopenta[b]Pyridine

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CAS号120-92-3 环戊酮 | CAS号2450-71-7 炔丙胺 | CAS号7148-07-4 1-吡咯烷基-1-环戊烯 | CAS号289-96-3 1,2,3-三嗪 | CAS号56946-65-7 2,4-二氯-6,7-二氢-5... | CAS号96-41-3 环戊醇 | CAS号156-87-6 3-氨基丙醇 | CAS号54664-50-5 Benzeneethanesu... | CAS号41598-71-4 6,7-二氢-5H-环戊并[b... | CAS号270-91-7 5H-环戊并[b]吡啶 | CAS号270-92-8 7H-Cyclopenta[b... | CAS号253-69-0 1,7-萘啶 | CAS号31170-78-2 5,6-二氢-7H-环戊并[b... | CAS号28566-14-5 6,7-二氢环戊烷并[b]吡啶-5-酮 | CAS号89-00-9 吡啶-2,3-二羧酸 | CAS号84957-29-9 头孢匹罗 | CAS号253-72-5 1,6-萘啶 | CAS号90685-58-8 6,7-二氢-5H-环戊并[b...

头孢匹罗置于sodium Hydroxide体系中,化学反应 2.0H,以52 Mg的收率获得产物2,3-环戊烯并吡啶
参考文献:头孢吡咯(hr 810)在水溶液中的稳定性和降解模式.
标题:头孢吡咯(hr 810)在水溶液中的稳定性和降解模式.
摘要:新型半合成头孢菌素1-[[((6R,7R)-7-[2-(2-氨基-4-噻唑基)乙醛酰氨基]-2-羧基-8-Ox O-5的稳定性和降解途径-Thia-1-Azabicyclo [4.2.0] oct-2-En-3-Yl] Methyl]-6,7-Dihydro-5H-1-吡啶鎓氢氧化物,内盐,7(2)-(z)-(研究了o-甲基肟)(硫酸头孢吡肟,Hr 810).将头孢哌啶酮在各种缓冲溶液中的温度保持在40摄氏度,并通过高效液相色谱法研究其降解模式.头孢哌酮在ph 4-7范围内稳定,超出此范围则略有不稳定.在从中性到碱性区域的水溶液中,产生的降解产物为:1-[[((6R,7S)-7)-[2-(2-氨基-4-噻唑基)乙氧基酰氨基]-2-羧基-8-氧代.-5-Thia-1-Azabicyclo [4.2.0] oct-2-En-3-Yl] Methyl]-6,7-Dihydro-5
DOI:10.1248/cpb.38.1998

专利信息

专利号:US-11897914-B2
优先权日:2021-11-29
标题 :Synthesis of 2′ protected nucleosides
发明人：POON WING C; ZOU RUIMING; LAU ALDRICH N K; YU DAVID; Du Gengyu; YAO YUN-CHIAO; ZHAO GANG
权利人:HONGENE BIOTECH CORP
摘要:Embodiments of the present application relate to the preparation of 2′-O-protected nucleoside phosphoramidites and conjugation of the 2′-O-protected nucleoside to a solid support. More specifically, the present application relates to nucleosides having a hydroxy protecting group at the 2′ position that reduces migration to the 3′ position during RNA (e.g., mRNA) synthesis and can be readily removed under mild conditions without the use of toxic metal-containing reagents. Methods of using the nucleosides described herein in RNA synthesis are also disclosed.

专利号:US-2023119227-A1
优先权日:2020-02-24
标 题:Oligonucleotide synthesis on solid support
发明人：JI AN; MARVIN MICHAEL; MARKS KEVIN; ANDERSON DAVID
权利人:INTEGRATED DNA TECH INC
摘要:Functionalized solid supports are useful in the synthesis of oligonucleotides. The functionalized solid supports contain an extended linker to a terminal functional group or a first nucleotide or nucleoside moiety. The extended linker permits oligonucleotide synthesis to take place at a greater distance from the solid support with greater efficiency.

专利号:US-4576949-A
优先权日:1984-05-07
标题 :Use of 5,6,7,8-tetrahydroquinolines and 5,6-dihydropyrindines as leukotriene and lipoxygenase inhibitors and the novel 3-substituted compounds therein
发明人：SMITH HERMAN W
权利人:UPJOHN CO
摘要:The present invention also provides novel compositions of matter. In particular, the present invention provides novel 3-substituted compounds of formula I which are from among the selected 5,6,7,8-tetrahydroquinolines and 5,6-dihydropyrindines having use as inhibitors of the synthesis of leukotrienes and as inhibitors of the action of lipoxygenase in mammalian metabolism.

专利号:US-10300471-B2
优先权日:2013-10-08
标题 :Ruthenium-catalyzed synthesis of biaryl compounds in water
发明人：KOOHANG ALI AIDEN; MEHTA ANITA
权利人:CHICAGO DISCOVERY SOLUTIONS LLC
摘要:Using a [RuCl 2 (arene)] 2 complex and a formate source, a directed ortho C—H insertion and aryl-aryl coupling sequence in water provides biaryl compounds useful in the preparation of biologically active molecules and intermediates. Reactions may be conducted in the ambient atmosphere. Ruthenium catalysts prepared from [RuCl 2 (arene)] 2 and a formate source may be prepared in situ or isolated for later use.

专利号:US-9006421-B2
优先权日:2013-03-14
标题 :Cephalosporin compositions and methods of manufacture
发明人：LAI JAN-JI; PATHARE PRADIP M; KOLLA LAXMA; SORET ADRIEN F
权利人:CUBIST PHARM INC
摘要:Provided herein is a method for the synthesis of cephalosporin antibiotic compounds comprising the conversion of a protected 7-amino group into a 7-carboxamide moiety in a single step.

专利号:US-12180140-B2
优先权日:2022-12-23
标 题 :Compounds and methods for liquid phase oligonucleotide synthesis
发明人：YANG GAOMAI; XIE MIN; YANG HONGRONG; WANG SHENGDONG; LAU ALDRICH N K; ZOU RUIMING; YU DAVID
权利人:HONGENE BIOTECH CORP
摘要:The present disclosure relates to methods and compounds for liquid phase oligonucleotide synthesis employing the use of small molecules with lipophilic groups. Methods for making an oligonucleotide by liquid phase oligonucleotide synthesis using the compounds described herein are also provided.