CAS: 5043-01-6; 6-Fluoro-2-Naphthoic Acid

该化合物是一种芳香化合物,其特点是存在氟原子和一个附于氯化萘环系统的碳酸性功能组;该化合物的特点是由两个有引信的苯乙烯环构成的氯化萘脊椎,具有显著稳定性和疏水特性;六点的氟替代成分可增强化合物的再活动性,并能影响其电子特性,使其在各种化学反应和应用中发挥作用;2点的箱酸组具有极地特性,允许氢结合和极地溶剂中的溶液增加;这种分子的欧洲联苯和水益特性使其成为有机合成中有价值的中间体,特别是在药物和农业化学的开发中;此外,该化合物的独特结构可产生具体的生物活动,使其对药用化学产生兴趣.

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相似化合物

5043-00-5 13790-83-5 702640-90-2

欧盟法规

ECHA物质C&L通报

上下游产品

CAS号702640-90-2 ethyl 6-fluoron... | CAS号7499-66-3 6-溴-2-氨基萘 | CAS号324-41-4 2-溴-6-氟萘 | CAS号13790-83-5 6-fluoronaphtha... | CAS号33627-02-0 1-(6-氟萘-2-基)乙酮 | CAS号5043-00-5 6-氟-2-萘甲酸甲酯 | CAS号324-41-4 2-溴-6-氟萘 | CAS号5043-00-5 6-氟-2-萘甲酸甲酯 | CAS号13916-91-1 6-氟萘-2-胺

合成工艺路线路线简述

    📜6-氟萘-2-甲腈置于硫酸,溶剂黄146体系中,化学反应生成 6-氟-2-萘甲酸
    参考文献:Substituent Effects. Viii.1 Synthesis Of Substituted α-And β-Fluoronaphthalenes2
    标题:Substituent Effects. Viii.1 Synthesis Of Substituted α-And β-Fluoronaphthalenes2
    摘要:
    DOI:10.1021/ja00978A038

    海关参考信息

    专利信息


    专利号:US-2022281888-A1
    优先权日:2019-09-25
    标题:Bicyclic carboxylates as modulators of transporters and uses thereof
    发明人:SANDANAYAKA VINCENT; GORECZNY GREGORY
    权利人:NIROGY THERAPEUTICS INC
    摘要:The present invention generally relates to the field of transporter modulators, e.g., monocarboxylate transporter inhibitors, and more particularly to new bicyclic enone carboxylate compounds, the synthesis and use of these compounds and their pharmaceutical compositions, e.g., in the treatment, modulation and/or prevention of physiological conditions associated with monocarboxylate transporter activity such as in treating cancer and other neoplastic disorders, tissue and organ transplant rejection.

    专利号:US-8859626-B2
    优先权日:2010-03-08
    标题 :Anti-virulence compositions and methods
    发明人:SHOHAM MENACHEM
    权利人:SHOHAM MENACHEM; UNIV CASE WESTERN RESERVE
    摘要:A method of reducing the virulence of a bacterium that expresses accessory gene regulator A (AgrA) includes administering to the bacterium an amount of AgrA antagonist effective to inhibit the synthesis of one or more virulence factors by the bacterium.

    专利号:US-11382882-B2
    优先权日:2010-03-08
    标 题 :Anti-virulence compositions and methods
    发明人:SHOHAM MENACHEM
    权利人:UNIV CASE WESTERN RESERVE
    摘要:A method of reducing the virulence of a bacterium that expresses accessory gene regulator A (AgrA) includes administering to the bacterium an amount of AgrA antagonist effective to inhibit the synthesis of one or more virulence factors by the bacterium.

    专利号:US-9868718-B2
    优先权日:2006-01-06
    标 题 :Cycloalkylamines as monoamine reuptake inhibitors
    发明人:SHAO LIMING; WANG FENGJIANG; MALCOLM SCOTT CHRISTOPHER; HEWITT MICHAEL CHARLES; BUSH LARRY R; MA JIANGUO; VARNEY MARK A; CAMPBELL UNA; ENGEL SHARON RAE; HARDY LARRY WENDELL; KOCH PATRICK; CAMPBELL JOHN E
    权利人:SUNOVION PHARMACEUTICALS INC
    摘要:The invention relates to novel cyclohexylamine derivatives and their use in the treatment and/or prevention of central nervous system (CNS) disorders, such as depression, anxiety, schizophrenia and sleep disorder as well as methods for their synthesis. The invention also relates to pharmaceutical compositions containing the compounds of the invention, as well as methods of inhibiting reuptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine from the synaptic cleft and methods of modulating one or more monoamine transporter.

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    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    合成参考文献


    参考文献:10.3389/fmolb.2022.880432
    摘要:Thomas SE, McCarthy WJ, El Bakali J, Brown KP, Kim SY, Blaszczyk M, Mendes V, Abell C, Floto RA, Coyne AG, Blundell TL. Structural Characterization of Mycobacterium abscessus Phosphopantetheine Adenylyl Transferase Ligand Interactions: Implications for Fragment-Based Drug Design. Front Mol Biosci. 2022;9():880432.
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