专利号:US-2022281888-A1 优先权日:2019-09-25 标题:Bicyclic carboxylates as modulators of transporters and uses thereof 发明人:SANDANAYAKA VINCENT; GORECZNY GREGORY 权利人:NIROGY THERAPEUTICS INC 摘要:The present invention generally relates to the field of transporter modulators, e.g., monocarboxylate transporter inhibitors, and more particularly to new bicyclic enone carboxylate compounds, the synthesis and use of these compounds and their pharmaceutical compositions, e.g., in the treatment, modulation and/or prevention of physiological conditions associated with monocarboxylate transporter activity such as in treating cancer and other neoplastic disorders, tissue and organ transplant rejection.
专利号:US-8859626-B2 优先权日:2010-03-08 标题 :Anti-virulence compositions and methods 发明人:SHOHAM MENACHEM 权利人:SHOHAM MENACHEM; UNIV CASE WESTERN RESERVE 摘要:A method of reducing the virulence of a bacterium that expresses accessory gene regulator A (AgrA) includes administering to the bacterium an amount of AgrA antagonist effective to inhibit the synthesis of one or more virulence factors by the bacterium.
专利号:US-11382882-B2 优先权日:2010-03-08 标 题 :Anti-virulence compositions and methods 发明人:SHOHAM MENACHEM 权利人:UNIV CASE WESTERN RESERVE 摘要:A method of reducing the virulence of a bacterium that expresses accessory gene regulator A (AgrA) includes administering to the bacterium an amount of AgrA antagonist effective to inhibit the synthesis of one or more virulence factors by the bacterium.
专利号:US-9868718-B2 优先权日:2006-01-06 标 题 :Cycloalkylamines as monoamine reuptake inhibitors 发明人:SHAO LIMING; WANG FENGJIANG; MALCOLM SCOTT CHRISTOPHER; HEWITT MICHAEL CHARLES; BUSH LARRY R; MA JIANGUO; VARNEY MARK A; CAMPBELL UNA; ENGEL SHARON RAE; HARDY LARRY WENDELL; KOCH PATRICK; CAMPBELL JOHN E 权利人:SUNOVION PHARMACEUTICALS INC 摘要:The invention relates to novel cyclohexylamine derivatives and their use in the treatment and/or prevention of central nervous system (CNS) disorders, such as depression, anxiety, schizophrenia and sleep disorder as well as methods for their synthesis. The invention also relates to pharmaceutical compositions containing the compounds of the invention, as well as methods of inhibiting reuptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine from the synaptic cleft and methods of modulating one or more monoamine transporter.
参考文献:10.3389/fmolb.2022.880432 摘要:Thomas SE, McCarthy WJ, El Bakali J, Brown KP, Kim SY, Blaszczyk M, Mendes V, Abell C, Floto RA, Coyne AG, Blundell TL. Structural Characterization of Mycobacterium abscessus Phosphopantetheine Adenylyl Transferase Ligand Interactions: Implications for Fragment-Based Drug Design. Front Mol Biosci. 2022;9():880432.