CAS: 42822-86-6; 2-(2-Hydroxypropan-2-yl)-5-Methylcyclohexanol

该化合物是源自月球的双环有机化合物,具有3和8个姿势的氢氧基质,具有独特的结构特征,其特点是三和八个姿势,带有氢氧基,具有化学特性.该化合物一般是无色的,可粉黄,具有舒适的薄荷味,吸引人们在各种应用中使用,特别是在香味和口味行业中.p-Menthane-3,8-dol 显露反微生物特性,可对个人护理产品和防腐剂有益,还因其冷却感知效作用而闻名,类似于月球,因此在热刺激皮肤的热时配方中有用.该化合物在酒精和油中溶解,但水溶解度有限.其稳定性和低毒性特征进一步增强了其消费品的用途.

结构式图片

相似化合物

2451-01-6 15356-60-2 2216-51-5

欧盟法规

[欧盟《生物杀灭剂法规》

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CAS号89-49-6 乙酸异胡薄荷酯 | CAS号3304-24-3 Cyclohexanone,2...

合成工艺路线路线简述

    (+)-香茅醛置于溶剂黄146体系中,化学反应生成 孟二醇
    参考文献:Grignard; Doeuvre,Comptes Rendus Hebdomadaires Des Seances De L'Academie Des Sciences,1928,Vol. 187,P. 272
    标题:Grignard; Doeuvre,Comptes Rendus Hebdomadaires Des Seances De L'Academie Des Sciences,1928,Vol. 187,P. 272

    海关参考信息

    专利信息


    专利号:US-2018312463-A1
    优先权日:2015-10-22
    标题:Synthesis of Cyclohexane Carboxamide Derivatives Useful as Sensates in Consumer Products
    发明人:YELM KENNETH EDWARD; WOS JOHN AUGUST; BUNKE GREGORY MARK; FREDERICK HEATH; HAUGHT JOHN CHRISTIAN; HOKE STEVEN HAMILTON; SREEKRISHNA KOTI TATACHAR; LIN YAKANG
    权利人:PROCTER & GAMBLE
    摘要:Synthesis methods to produce a series of carboxamides built off of an (S)-2-amino acid backbone or an (R)-2-amino acid backbone, depending upon the desired diastereomer of the end product.

    专利号:US-2019276389-A1
    优先权日:2015-12-18
    标题:Synthesis of aryl cyclohexane ester derivatives useful as sensates in consumer products
    发明人:WOS JOHN AUGUST; YELM KENNETH EDWARD; BUNKE GREGORY MARK; FREDERICK HEATH ALAN; REILLY MICHAEL; HAUGHT JOHN CHRISTIAN; SREEKRISHNA KOTI TATACHAR; LIN YAKANG
    权利人:PROCTER & GAMBLE
    摘要:Personal care compositions, such as oral care and skin care compositions containing a flavor/perfume system comprising one or more coolants. The pleasant cool sensation provided by a coolant is enhanced in terms of quicker onset, greater intensity, impact or longer duration, which improves appeal and acceptability of the compositions to consumers.

    专利号:US-8754259-B2
    优先权日:2008-08-15
    标 题 :Synthesis of cyclohexane derivatives useful as sensates in consumer products
    发明人:YELM KENNETH EDWARD; BUNKE GREGORY MARK; HAUGHT JOHN CHRISTIAN
    权利人:PROCTER & GAMBLE; PROCTER & GAMBLE
    摘要:The present invention provides synthetic routes for preparing various isomers of cyclohexane-based coolants, such as menthyl esters and menthanecarboxamide derivatives, in particular those substituted at the amide nitrogen, for example with an aromatic ring or aryl moiety. Such structures have high cooling potency and long lasting sensory effect, which make them useful in a wide variety of consumer products. One synthetic route involves a copper catalyzed coupling of a primary menthanecarboxamide with an aryl halide, such reaction working best in the presence of potassium phosphate and water. Using this synthetic route, specific isomers can be prepared including the menthanecarboxamide isomer having the same configuration as l-menthol and new isomers such as a neoisomer having opposite stereochemistry at the carboxamide (C-1) position. The neoisomer unexpectedly has potent and long lasting cooling effect. Preparation schemes for neoisomers of other menthyl derivatives which are useful as coolants, including esters, ethers, carboxy esters and other N-substituted carboxamides are also provided.

    专利号:US-2004127553-A1
    优先权日:2002-03-20
    标 题 :Insect repellent compositions comprising dihydronepetalactone
    发明人:HALLAHAN DAVID L
    摘要:Dihydronepetalactone, a minor natural constituent of the essential oil of catmints (Nepeta spp.) such as Nepeta cataria , has been identified as an effective insect repellent compound. Synthesis of dihydronepetalactone may be achieved by hydrogenation of nepetalactone, the major constituent of catmint essential oils. This compound, which also has fragrance properties, may be used commercially for its insect repellent properties.

    专利号:US-7232844-B2
    优先权日:2002-03-20
    标 题:Insect repellent compounds
    发明人:HALLAHAN DAVID L
    权利人:DU PONT
    摘要:Dihydronepetalactone, a minor natural constituent of the essential oil of catmints (Nepeta spp.) such as Nepeta cataria, has been identified as an effective insect repellent compound. Synthesis of dihydronepetalactone may be achieved by hydrogenation of nepetalactone, the major constituent of catmint essential oils. This compound, which also has fragrance properties, may be used commercially for its insect repellent properties.

    专利号:US-8633325-B2
    优先权日:2002-03-20
    标 题:Method for making insect repellent composition
    发明人:HALLAHAN DAVID L; MANZER LEO ERNEST
    权利人:HALLAHAN DAVID L; MANZER LEO ERNEST; DU PONT
    摘要:Dihydronepetalactone, a minor natural constituent of the essential oil of catmints ( Nepeta spp.) such as Nepeta cataria , has been identified as an effective insect repellent compound. Synthesis of dihydronepetalactone may be achieved by hydrogenation of nepetalactone, the major constituent of catmint essential oils. This compound, which also has fragrance properties, may be used commercially for its insect repellent properties, and methods for making an composition thereof are disclosed.
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    合成参考文献


    参考文献:10.1016/j.phytochem.2006.04.025
    摘要:Yadegarinia D, Gachkar L, Rezaei MB, Taghizadeh M, Astaneh SA, Rasooli I. Biochemical activities of Iranian Mentha piperita L. and Myrtus communis L. essential oils. Phytochemistry. 2006 Jun;67(12):1249–55. doi: 10.1016/j.phytochem.2006.04.025.
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