CAS: 38379-99-6; 2,2',3,5',6-Pentachloro-1,1'-Biphenyl
该化合物是一种多氯联苯同族体,其特征是2,2',3,5'和6个位置的5个氯替代物,该化合物主要用于研究和分析应用,因其持久性和生物累积潜力,作为环境和毒理学研究的参考标准,其明确的结构和稳定性使其适于用于色谱学和质谱学,作为校准标准.此外,它也是研究生物系统中多氯联苯降解途径和代谢行为的示范化合物,由于毒性和环境危害,需要谨慎处理.
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;;;; - InChIKey: GXNNLIMMEXHBKV-UHFFFAOYSA-N
- 1S/C12H5Cl5/c13-6-1-2-8(14)7(5-6)11-9(15)3-4-10(16)12(11)17/h1-5H
- 计算化学: 氢键受体数*氢键供体数*可旋转键数1.0
物理性质
MSDS等安全信息
- GHS符号GHS07
- 警示词Warning
- 危险描述H302-H315-H319-H335
- 防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
- 安全声明The mechanism of action varies with the specific PCB. Dioxin-like PCBs bind to the aryl hydrocarbon receptor, which disrupts cell function by altering the transcription of genes, mainly be inducing the expression of hepatic Phase I and Phase II enzymes, especially of the cytochrome P450 family. Most of the toxic effects of PCBs are believed to be results of Ah receptor binding. Other PBCs are believed to interfere with calcium channels and/or change brain dopamine levels. PCBs can also cause endocrine disurption by altering the production of thyroid hormones and binding to estrogen receptors, which can stimulate the growth of certain cancer cells and produce other estrogenic effects, such as reproductive dysfunction. They will bioaccumulate by binding to receptor proteins such as uteroglobin. (A3, A4, A30, A66)
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2,2',3,3',6,6'-hexachlorobiphenyl合成工艺路线路线简述
📜Alkaline Earth Salt Of/the/ Methylsulfuric Acid置于air体系中,化学反应生成2,2',3,5',6-戊氯联苯
参考文献:英国国内煤炭和木材燃烧产生的pcdd / Fs,Pcbs,Pcns,Pahs和pm10的排放因子和重要性
标题:英国国内煤炭和木材燃烧产生的pcdd / Fs,Pcbs,Pcns,Pahs和pm10的排放因子和重要性
摘要:本文介绍了当煤和木材经过受控燃烧实验时针对一系列持久性有机污染物(pops)得出的排放因子(efs),旨在模拟空间供暖的家庭燃烧.排放了各种各样的持久性有机污染物,煤炭的排放量高于木材的排放量.对于颗粒物,Pm10(大约10 G / Kg燃料)和多环芳烃(对于sigmapahs大约100 Mg / Kg燃料)获得了最高的ef.对于氯化物,多氯联苯(pcb)的ef最高,而多氯萘(pcn),二苯并-对-二恶英(pcdd)和二苯并呋喃(pcdf)的丰度较低.对于sigmapcb,Ef大约为1000 Ng / Kg燃料,对于sigmapcns大约为100S Ng / Kg燃料,对于sigmapcdd / Fs大约为100 Ng / Kg燃料.该研究证实,一氯化至三氯化二苯并呋喃cl1,2,3Dfs是低温燃烧过程(如煤炭和木材的国内燃烧)的有力指标.结论是,在固体燃料燃烧期间通常形成许多pcb和pc
Doi:10.1021/es048745I
海关参考信息
- 2903911000-邻二氯苯
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主要参考文献
参考标题:Synthesis Of Sterically Hindered Polychlorinated Biphenyl Derivatives作者:H.-J. Lehmler,S. Joshi,S. Vyas,M. Duffel,S. Parkin |发布日期:2011.4
摘要:A Series Of Sterically Hindered (Methoxylated) Polychlorinated Biphenyl Derivatives Were Synthesized Using The Suzuki And The Ullmann Coupling Reactions. The Suzuki Coupling With Pd(Dba)2/2-Dicyclohexylphosphino-2′,6′-Dimethoxybiphenyl (Dpdb) Gave Better Yields (65-98%) Compared To The Classic Ullmann Coupling Reaction (20-38%). Despite The Reactive Catalyst System, No Significant Coupling With Aromatic
合成参考文献
摘要:S109 | PARCEDC | List of 7074 potential endocrine disrupting compounds (EDCs) by PARC T4.2 | DOI:10.5281/zenodo.10944198
参考文献:10.1016/j.tox.2015.10.002
摘要:Stamou M, Uwimana E, Flannery BM, Kania-Korwel I, Lehmler HJ, Lein PJ. Subacute nicotine co-exposure has no effect on 2,2',3,5',6- pentachlorobiphenyl disposition but alters hepatic cytochrome P450 expression in the male rat. Toxicology. 2015 Dec 02;338():59–68.
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