CAS: 346688-38-8; 4-(3-(Methylsulfonyl)Phenyl)-1-Propylpiperidine

上下游产品

4-(3-甲基磺酰基苯基)哌啶 4-(3-(Methylsulfonyl)Phenyl)Piperidine 346688-72-0
4-(3-Methylsulfanyl-Phenyl)-1-Propyl-Piperidine 1071930-28-3
4-羟基-4-(3-甲硫基苯基)-1-丙基哌啶 4-(3-(Methylthio)Phenyl)-1-Propylpiperidin-4-Ol 882737-40-8
4 - [3 - (二甲基)苯基] - 1 -丙基-1,2,3,6 -四氢 4-(3-(Methylsulfonyl)Phenyl)-1-Propyl-1,2,3,6-Tetrahydropyridine 346688-39-9

📜4-溴-N-Boc-哌啶置于六氟磷酸钾,Bis(1,3-Bis((4-Methyl-2-Pyridyl)Imino)Isoindolinato)Nickel(II),C22H19N5Nio2,Potassium Carbonate,三氟乙酸体系中,用 二氯甲烷,N,N-二甲基乙酰胺,乙腈 作为反应溶剂,化学反应 28.0H,反应生成 4-[3-(甲基磺酰基)苯基]-1-丙基哌啶
参考文献:通过均相电催化剂的过充电保护实现的一般 C(Sp2)-C(Sp3) 交叉电极偶联反应
标题:通过均相电催化剂的过充电保护实现的一般 C(Sp2)-C(Sp3) 交叉电极偶联反应
摘要:由电化学促进的烷基和芳基卤化物的交叉亲电偶联 (Xec) 代表了需要化学计量数量的高能还原剂的传统方法的有吸引力的替代方法.最重要的是,电还原可以很容易地超过化学还原剂的还原电位,从而以改进的反应性和选择性激活催化剂,否则这些催化剂与传统还原剂不相容.这项工作详细介绍了 Xec 电化学方法的机械驱动开发,该方法利用储能社区开发的氧化还原活性穿梭机来保护反应偶联催化剂免于过度还原.所得电催化体系实用,可扩展,并广泛适用于各种芳基,杂芳基,或乙烯基溴与伯或仲烷基溴.过充电保护作为电合成方法策略的影响通过添加氧化还原梭(通常>80%)和没有添加氧化还原梭(通常<20%)的偶联反应产率的巨大差异得到强调.除了对广泛的底物具有出色的产率外,还可以在高电流和数克规模下进行防止过度还原的反应.
DOI:10.1021/jacs.0C01475

专利信息

专利号:US-2007238878-A1
优先权日:2004-10-13
标 题 :Process for the synthesis of 4-(3-sulfonylphenyl)-piperidines
发明人：DESMOND RICHARD; DEVINE PAUL N; SONESSON CLAS; GAUTHIER DONALD R
权利人:DESMOND RICHARD; DEVINE PAUL N; SONESSON CLAS; GAUTHIER DONALD R
摘要:The present invention is directed to processes for the preparation of 4-(sulfonylphenyl)-piperidines of the Formula (VI), and pharmaceutically acceptable salts thereof; which comprises oxidizing a sulfide of the Formula (VII) or Formula (VIII), to give a compound of the Formula (IX) or Formula (X) respectively, followed by catalic reduction of the compound of the Formula (IX) or dehydration of compound of formula (X) to give a compound of Formula (IX) followed by catalytic reduction of the compound formula (IX) to give the compound of the Formula (VI).

专利号:US-7923459-B2
优先权日:2004-10-13
标题 :Process for the synthesis of 4-(3-methanesulfonylphenyl)-1-N-propyl-piperidine
发明人：GAUTHIER DONALD R; DESMOND RICHARD; DEVINE PAUL N
权利人:NSAB AF NEUROSEARCH SWEDEN AB
摘要:The present invention is directed to processes for the preparation of 4-(3-methanesulfonyl-phenyl)-1-N-propylpiperidine (I) or a pharmaceutically acceptable salt thereof, which comprises: oxidizing a sulfide of the formula (II): with a catalytic oxidizing agent and an oxidant; to give a compound of the formula (III): followed by catalytic reduction of the compound of formula (III).

专利号:US-2007238879-A1
优先权日:2004-10-13
标题 :Process for the synthesis of 4-(3-methanesulfonylphenyl)-1-n-propyl-piperidine

专利号:AU-2005293754-A1
优先权日:2004-10-13
标 题 :Process for the synthesis of 4-(3-methanesulfonylphenyl)-1-N-propyl-piperidine

专利号:AU-2005293755-A1
优先权日:2004-10-13
标 题:Process for the synthesis of 4-(3-sulfonylphenyl)-piperidines

专利号:CA-2584831-A1
优先权日:2004-10-13
标题 :Process for the synthesis of 4-(3-methanesulfonylphenyl)-1-n-propyl-piperidine