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专利信息
专利号:US-7468375-B2
优先权日:2004-04-26
标题:Inhibitors of the HIV integrase enzyme
发明人:DRESS KLAUS RUPRECHT; HU QIYUE; JOHNSON TED WILLIAM; PLEWE MICHAEL BRUNO; TANIS STEVEN PAUL; WANG HAI; YANG ANLE; YIN CHUNFENG; ZHANG JUNHU
权利人:PFIZER
摘要:The present invention is directed to compounds of formula (I), and pharmaceutically acceptable salts and solvates thereof, their synthesis, and their use as modulators or inhibitors of the human immunodeficiency virus (“HIVâ€?) integrase enzyme.
专利号:US-2005009151-A1
优先权日:2003-07-10
标 题 :Methods for the stereospecific and enantiomeric enrichment of beta-amino acids
发明人:CHASE MATTHEW; CLAYTON ROBERT; LANDIS BRYAN; BANERJEE AMIT
权利人:PHARMACIA CORP
摘要:The present invention relates to methods for the stereospecific synthesis and for the enantiomeric enrichment of β-amino acids. A novel D-β-aminotransferase, which exhibits stereoselectivity for D-β-phenylalanine, (D-3 amino-3-phenylpropinine acid) was purified from a newly-isolated strain of Variouorax paradoxus . A novel L-β-aminotransferase was purified from a newly-isolated strain of Alcaligenes eutrophus . The D- and L-β-aminotransferases can be used to facilitate the stereoselective biosynthesis of β-D-phenylalanine or β-L-phenylalanine, from a mixture of L-glutamic acid or L-alanine, respectively, and 3-keto-3-phenylpropionic acid in the presence of the cofactor pyridoxal phosphate.
专利号:KR-20190053958-A
优先权日:2016-09-29
标题:Methods for the synthesis of novel chiral ligands, metal chelates, various unnatural amino acids,
专利号:RU-2727723-C1
优先权日:2016-09-29
标 题 :Method for synthesis of novel chiral ligand, metal chelate, various unnatural amino acids, maraviroc and main intermediate compounds thereof
专利号:JP-2007526751-A
优先权日:2003-07-10
标 题:Stereoselective synthesis method and enantiomeric enrichment method of β-amino acid
专利号:MX-PA06000367-A
优先权日:2003-07-10
标题:METHODS FOR STEREOSELECTIVE SYNTHESIS AND ENANTIOMERIC ENRICHMENT OF BETA-AMINO ACIDS.