CAS: 268221-76-7; 3-((2S,5S)-5-Methyl-3,6-Dioxopiperazin-2-yl)Propanamide

📜N-叔丁氧羰基-L-丙氨酸,Boc-L-谷氨酰胺置于1-羟基苯并三唑,4-二甲氨基吡啶,N,N-二异丙基乙胺,N,N'-二异丙基碳二亚胺体系中,用 二氯甲烷,N,N-二甲基甲酰胺 用作溶剂,化学反应 3.0H,反应生成环-(L-丙氨酰-L-谷氨酰胺)
参考文献:Interfacial Supramolecular Biomimetic Epoxidation Catalysed By Cyclic Dipeptides
标题:Interfacial Supramolecular Biomimetic Epoxidation Catalysed By Cyclic Dipeptides
摘要:We Synthesised A Library Of Cis-And Trans-Cyclic Dipeptides And Evaluated Their Efficacy As Catalysts In The Asymmetric Weitz-Scheffer Epoxidation Of Trans-Chalcone. A Thorough Investigation Relying On Structure-Activity Studies And Computational Studies Provided Insights Into The Mechanism Of The Process. Our Results Revealed Some Structural Features Required For Efficient Conversion And For Introduction Of Chirality Into The Product. The Cyclic Dipeptide Acts As A Catalyst By Templating A Supramolecular Arrangement At The Aqueous-Organic Interface Required For Efficient Transformations To occur. Among All Cyclic Dipeptides Investigated,Cyclo(Leu-Leu) Was The Most Efficient Supramolecular Catalyst.[graphics].
Doi:10.1080/10610278.2016.1236197