专利号:US-11976081-B2 优先权日:2019-04-26 标题 :Intermediate of eribulin and synthesis method and use thereof 发明人:XU WEIPING 权利人:BEIJING TIENYI LUFU PHARMATECH CO LTD 摘要:An intermediate compound is prepared and used for the synthesis of halichondrin B, eribulin or an analog thereof, particularly a structural fragment C27-C35 thereof. The starting materials of the synthetic route are readily available, and the optical purity of the starting materials can be ensured, so that the optical purity of the structural fragment C27-C35 in halichondrin B, eribulin or the analog thereof is ensured. Steps for constructing a chiral center of the structural fragment C27-C35 feature higher diastereoselectivity and yield, in particular preparation methods of compounds of formulae (X), (XI), (XVI) and (XV). By-products of partial reactions can be removed only by recrystallization, which results in easy purification and significant reduce in cost.
专利号:US-11905246-B2 优先权日:2014-05-26 标 题 :Design, synthesis and characterization of metal organic frameworks 发明人:EDDAOUDI MOHAMED; XUE DONGXU; LUEBKE RYAN; GUILLERM VINCENT; PEEDIKAKKAL ABDUL MALIK PUTHAN; ADIL KARIM; WESELINSKI LUKASZ 权利人:UNIV KING ABDULLAH SCI & TECH; KING ABDULLAH UNIV OF SCIENCE & TECHNOLOGY 摘要:A molecular building block composition can include a metal ion component; and a ligand component including a core including at least one functional group associated with the metal ion component and the core.
专利号:US-12398168-B2 优先权日:2020-01-09 标题 :Preparation method of a glycoside compound 发明人:ZHAN CHANGSEN; TIAN PING; CUI CHUNXIAO; ZHANG JIANGE; ZHOU JUNJIE; LIN GUOQIANG; XU WENWEN; ZHANG ZHENGGUANG 权利人:SHANGHAI HUTCHISON PHARMACEUTICALS LTD 摘要:Preparation method of glycoside compounds is involved in the invention, with the advantages of short synthesis steps, high stereoselectivity and yield, simple production operation, low equipment requirements, environmental protection and suitability for industrial mass production.
专利号:US-5877214-A 优先权日:1996-09-12 标题:Polyaryl-poly(ethylene glycol) supports for solution-phase combinatorial synthesis 发明人:KIM RONALD M 权利人:MERCK & CO INC 摘要:The present invention is directed to the certain polyaryl-poly(ethylene glycol) compounds ('polyaryl-PEG' compounds) which are useful as soluble polyvalent supports in the preparation of combinatorial libraries of compounds. The resultant combinatorial libraries are useful in screening for biologically active moieties in the drug discovery process or in developing compounds with desired physical and chemical properties.
专利号:CN-114572993-B 优先权日:2022-05-07 标题:Method and device for refining potassium fluoborate as byproduct in synthesis of medical intermediate
专利号:CN-114572993-A 优先权日:2022-05-07 标题:Method and device for purifying by-product potassium fluoroborate in synthesis of pharmaceutical intermediates
参考文献:10.1007/s12274-023-5605-2 摘要:Chang X, Huang L, Gao Y, Fu Y, Ma J, Yang H, Liu J, Fu X, Lin X, Feng X, Du S, Gao H. On-surface synthesis and edge states of NBN-doped zigzag graphene nanoribbons. Nano Res. 2023 Mar 26;16(7):10436–42. doi: 10.1007/s12274-023-5605-2.