CAS: 18776-12-0; 3-Chloro-1-Phenylpropan-1-Ol

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CAS号936-59-4 3-氯代苯丙酮 | CAS号14155-36-3 (1,3-Dichloro... | CAS号6323-18-8 1-(2-氯苯)-丙烷-1-酮 | CAS号4850-49-1 1-苯基丙烷-1,3-二醇 | CAS号34841-35-5 间氯苯丙酮 | CAS号7732-18-5 水 | CAS号104-52-9 3-苯基-1-氯丙烷 | CAS号5053-63-4 3-氨基-1-苯基丙烷-1-醇 | CAS号936-59-4 3-氯代苯丙酮 | CAS号100306-33-0 (R)-(+)-3-氯-1-苯... | CAS号42142-52-9 N-甲基-3-苯基-3-羟基丙胺 | CAS号19352-10-4 2-methyl-2-phen... | CAS号200004-12-2 1-(3-chloro-1-p... | CAS号21763-00-8 (1-溴-3-氯丙基)苯 | CAS号21763-01-9 (3-chloro-1-phe... | CAS号93-54-9 1-苯基-1-丙醇 | CAS号54910-89-3 氟西汀

1-氯-3-苯基丙烷置于三甲基硅乙酸酯,六氟异丙醇,水,Copper (I) Acetate体系中,用 二氯甲烷 用作溶剂,化学反应 17.0H,反应生成3-氯-1-苯基丙醇
参考文献:C-H 氧化合成苯甲醇
标题:C-H 氧化合成苯甲醇
摘要:由于醇进一步氧化为酮的倾向很高,选择性亚甲基c-H氧化合成具有广泛范围和官能团耐受性的醇具有挑战性.在这里,我们报道了使用双(甲磺酰基)过氧化物作为氧化剂选择性合成苄醇.我们试图为单氧化的选择性提供一个基本原理,这与之前的工作不同;质子耦合电子转移机制(pcet)可以解释反应性的差异.我们预计我们的方法将有助于药物和农用化学品的发现.
Doi:10.1021/jacs.9B09496

专利信息

专利号:US-6388128-B1
优先权日:1998-10-05
标 题:Stannane synthesis of prostanoids
发明人：CONROW RAYMOND E
权利人:ALCON MFG LTD
摘要:The present invention is directed to novel methods of prostanoid synthesis. Specifically, the invention is directed to the addition of alpha chains to prostanoids using cis-alkenylstannane intermediates.

专利号:US-6838581-B2
优先权日:2002-12-04
标题:Process for the preparation of enantiomerically pure 3-phenyl-3-hydroxypropylamine
发明人：KUMAR PRADEEP; PANDEY RAJESH KUMAR
权利人:COUNCIL SCIENT IND RES
摘要:The present invention relates to an improved process for the synthesis of enantiomerically pure 3-phenyl-3-hydroxypropylamine of formula I; more particularly the present invention relates to the said process using styrene; n n nthe synthetic strategy features a Sharpless asymmetric dihydroxylation (SAD) route to the target compound, using styrene, a readily accessible starting material gives the optically pure dihydroxy compound (ee >97%; the selective monotosylation of primary alcohol, nucleophilic displacement by cyano and subsequent reduction to amino group furnishes the desired 3-phenyl-3-hydroxypropylamine in enatiomerically pure form, a key intermediate in the synthesis of variety of oxetine related anti-depressant drugs.

专利号:US-6162949-A
优先权日:1994-12-16
标 题 :Process for preparation of the pharmaceutically desired (S)-oxetine enantiomers
发明人：GATTUSO MARK J
权利人:UOP LLC
摘要:Improved processes for preparation of the (S)-oxetines in high enantiomeric purity centers on resolution using simulated moving bed chromatography of a racemic precursor early in the oxetine synthesis. Resolution is effected with high enantiomeric purity, and subsequent reactions of the desired enantiomer performed with high optical specificity to maintain enantiomeric purity. The undesired enantiomer may be racemized and recycled to the resolution phase to avoid loss.

专利号:US-5889186-A
优先权日:1994-12-16
标 题:Process for preparation of the pharmaceutically desired (S)-oxetine enantiomers
发明人：GATTUSO MARK J
权利人:UOP INC
摘要:Improved processes for preparation of the (S)-oxetines in high enantiomeric purity centers on resolution using simulated moving bed chromatography of a racemic precursor early in the oxetine synthesis. Resolution is effected with high enantiomeric purity, and subsequent reactions of the desired enantiomer performed with high optical specificity to maintain enantiomeric purity. The undesired enantiomer may be racemized and recycled to the resolution phase to avoid undesired losses.

专利号:US-6458955-B1
优先权日:1994-12-16
标 题 :Process for preparation of pharmaceutically desired enantiomers
发明人：GATTUSO MARK J
权利人:UOP LLC
摘要:Improved processes for preparation of high enantiomeric purity compounds center on resolution using simulated moving bed chromatography of a racemic precursor early in the synthesis. Resolution is effected with high enantiomeric purity, and subsequent reactions of the desired enantiomer performed with high optical specificity to maintain enantiomeric purity. The undesired enantiomer is racemized and recycled to the resolution phase to avoid loss.

专利号:WO-0020386-A1
优先权日:1998-10-05
标 题 :Stannane synthesis of prostanoids