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二氯磷酸乙酯置于水体系中,化学反应 1.17H,反应生成磷酸单乙基酯
参考文献:用氨基酰基磷酸酯和镧盐对核糖核苷酸和 Rna 进行仿生氨基酰化
标题:用氨基酰基磷酸酯和镧盐对核糖核苷酸和 Rna 进行仿生氨基酰化
摘要:细胞中 Trna 的氨酰化涉及将氨基酸激活为氨酰腺苷酸,这是一种与 Amp 的混合酸酐,可与 Trna 反应.我们现在已经确定,在水中存在镧系元素离子的情况下,氨酰基磷酸酯会酰化 Rna 或简单核苷酸 3'-末端的羟基.通过扩展,这将允许在一步仿生过程中生产合成氨酰化的 Trna.Boc-4-氟苯丙氨酰乙基磷酸酯的反应随后进行HPLC分离,Ms和19F NMR分析.Boc-4-氟苯丙氨酰乙酯在水性缓冲液中与镧盐化学计量结合,迅速生成胞苷和胞苷单磷酸的 2'-和 3'-单酯.在镧盐和镁盐存在下,试剂与 Rna 的反应将特定可检测的信号引入 Rna,这是形成氨酰酯的证据.当相同的 Rna 最初被高碘酸盐氧化以将 3'-末端邻位二醇转化为裂解的二醛时,与氨基酰基磷酸酯的反应不再发生,如 19F NMR 光谱中缺乏信号所证明的那样.结果与必需的螯合机制一致,在该机制中,镧充当氨酰磷酸酯和 Rna 和核苷酸的
Doi:10.1021/ja073976L

专利信息

专利号:US-7435861-B2
优先权日:2005-04-29
标 题 :Methods for synthesis of carotenoids, including analogs, derivatives, and synthetic and biological intermediates
发明人：LOCKWOOD SAMUEL F; TANG PENG CHO; NADOLSKI GEOFF; JACKSON HENRY L; FANG ZHIQIANG; DU YISHU; YANG MIN; GEISS WILLIAM; WILLIAMS RICHARD; BURDICK DAVID
权利人:CARDAX PHARMACEUTICALS INC
摘要:A method for synthesizing intermediates for use in the synthesis of carotenoid synthetic intermediates, carotenoid analogs, and/or carotenoid derivatives. The carotenoid analog, derivative, or intermediate may be administered to a subject for the inhibition and/or amelioration of any disease that involves production of reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals. In some embodiments, the invention may include methods for synthesizing chemical compounds including an analog or derivative of a carotenoid. Carotenoid analogs or derivatives may include acyclic end groups. In some embodiments, a carotenoid analog or derivative may include at least one substituent. The substituent may enhance the solubility of the carotenoid analog or derivative such that the carotenoid analog or derivative at least partially dissolves in water.

专利号:US-2008221377-A1
优先权日:2006-06-16
标题 :Methods for synthesis of carotenoids, including analogs, derivatives, and synthetic and biological intermediates
发明人：LOCKWOOD SAMUEL F; TANG PENG CHO; NADOLSKI GEOFF; JACKSON HENRY L; FANG ZHIQIANG; DU YISHU; YANG MIN; GEISS WILLIAM; WILLIAMS RICHARD; BURDICK DAVID; BRAUN CRISTI L
权利人:LOCKWOOD SAMUEL F; TANG PENG CHO; NADOLSKI GEOFF; JACKSON HENRY L; FANG ZHIQIANG; DU YISHU; YANG MIN; GEISS WILLIAM; WILLIAMS RICHARD; BURDICK DAVID; BRAUN CRISTI L
摘要:A method for synthesizing intermediates for use in the synthesis of carotenoid synthetic intermediates, carotenoid analogs, and/or carotenoid derivatives. The carotenoid analog, derivative, or intermediate may be administered to a subject for the inhibition and/or amelioration of any disease that involves production of reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals. In some embodiments, the invention may include methods for synthesizing chemical compounds including an analog or derivative of a carotenoid. Carotenoid analogs or derivatives may include acyclic end groups. In some embodiments, a carotenoid analog or derivative may include at least one substituent. The substituent may enhance the solubility of the carotenoid analog or derivative such that the carotenoid analog or derivative at least partially dissolves in water.

专利号:WO-9323416-A1
优先权日:1992-05-13
标 题:Chemical synthesis of 2',3'-dideoxynucleoside 5'-triphosphates
发明人：MATULIC-ADAMIC JASENKA; BEIGELMAN LEONID
权利人:US BIOCHEMICAL CORP
摘要:Method for synthesis of 2',3'-dideoxynucleoside 5'-triphosphates by contacting a 2',3'-dideoxynucleoside with a phosphorylating agent in the presence of a proton removing reagent.

专利号:WO-9323415-A1
优先权日:1992-05-13
标 题 :CHEMICAL SYNTHESIS OF 2',3'-DIDEOXYNUCLEOSIDE 5'-(α-THIO) TRIPHOSPHATES
发明人：MATULIC-ADAMIC JASENKA; BEIGELMAN LEONID
权利人:US BIOCHEMICAL CORP
摘要:Method for synthesis of ddNTPαS by reacting a 2',3'-dideoxynucleoside with a mixture of thiophosphorylchloride and pyridine at a temperature less than 130 °C.

专利号:US-4092316-A
优先权日:1975-02-03
标题:Synthesis of C-alkyl-triethylenediamines
发明人：NIEH EDWARD C Y
权利人:TEXACO DEVELOPMENT CORP
摘要:A liquid phase synthesis of C-alkyl-triethylenediamines involves heating to elevated temperatures of from about 200° C to 300° C a suitable N-(2-hydroxyalkyl) piperazine feedstock in the presence of a catalytic amount of a pentavalent acidic phosphorus compound and then recovering the C-alkyl-triethylenediamine product from the resulting reaction product mixture.

专利号:US-2015099864-A1
优先权日:2013-10-08
标题:Preparation of organophosphate peptide adducts
发明人：BREWER BOBBY N; LUCAS ERIC A; BURKITT NATHAN T
权利人:BATTELLE MEMORIAL INSTITUTE
摘要:Disclosed are methods for the synthesis of organophosphorus-adducted peptides. Such peptides may be useful as biomarkers of organophosphate exposure, or for the synthesis of antibodies. Also disclosed are peptide adducts including peptide adducts of tabun, and aged adducts.