专利号:US-8329923-B2 优先权日:2010-06-17 标 题:4, 4′ disubstituted 4H-cyclopentadithiophene and new methods for synthesizing the same 发明人:VANDERZANDE DIRK; LUTSEN LAURENCE; VAN MIERLOO SARAH 权利人:VANDERZANDE DIRK; LUTSEN LAURENCE; VAN MIERLOO SARAH; IMEC; UNIV HASSELT 摘要:The present preferred embodiments relate to a method for the synthesis of a compound having the following general formula: n nthe method comprising the step of reacting, in presence of a diprotic acid having a negative pKa, a compound having the general formula:n n nwherein R 1 and R 2 are organic groups and wherein X and Y are independently selected from the group consisting of hydrogen, chloro, bromo, iodo, boronic acid, boronate esters, borane, pseudohalogen and organotin. It further relates to compounds so obtained and to compounds resulting from the ring closure of compound (II).
参考标题:Enantioselective Synthesis Of α-Allyl Amino Esters Via Hydrogen-Bond-Donor Catalysis 作者:Andrew J. Bendelsmith,Seohyun Chris Kim,Masayuki Wasa,Stéphane P. Roche,Eric N. Jacobsen |发布日期:2019.7.24 摘要:Diastereoselec-Tive Synthesis Of α-Allyl Amino Esters. The Optimized Protocol Provides Access To N-Carbamoyl-Protected Amino Esters Via Nucleophilic Allyla-Tion Of Readily Accessible α-Chloro Glycinates. A Variety Of Useful α-Allyl Amino Esters Were Prepared-Including Crotylated Products Bearing Vicinal Stereocenters That Are Inaccessible Through Enolate Alkylation-With High Enantioselectivity (Up To 97% Ee)
合成参考文献
摘要:Snaith, J. S., Science of Synthesis Knowledge Updates, (2011) 2, 190. 摘要:Snaith, J. S., Science of Synthesis Knowledge Updates, (2011) 2, 199.