CAS: 1449510-64-8; 6-(4-(5-Chloropentanamido)Phenyl)-1-(4-Methoxyphenyl)-7-Oxo-4,5,6,7-Tetrahydro-1H-Pyrazolo[3,4-C]Pyridine-3-Carboxamide

英文名称6-(4-(5-Chloropentanamido)Phenyl)-1-(4-Methoxyphenyl)-7-Oxo-4,5,6,7-Tetrahydro-1H-Pyrazolo[3,4-C]Pyridine-3-Carboxamide
中文名称阿哌沙班杂质26
IUPAC名称6-(4-(5-chloropentanamido)phenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide
其它别名Apixaban Impurity 26; 6-(4-(5-Chloropentanamido)Phenyl)-1-(4-Methoxyphenyl)-7-Oxo-4,5,6,7-Tetrahydro-1H-Pyrazolo[3,4-C]Pyridine-3-Carboxamide; 1H-Pyrazolo[3,4-C]Pyridine-3-Carboxamide, 6-[4-[(5-Chloro-1-Oxopentyl)Amino]Phenyl]-4,5,6,7-Tetrahydro-1-(4-Methoxyphenyl)-7-Oxo-; Apixaban Impurity 85; 6-[4-[(5-Chloro-1-Oxopentyl)Amino]Phenyl]-4,5,6,7-Tetrahydro-1-(4-Methoxyphenyl)-7-Oxo-1H-Pyrazolo[3,4-C]Pyridine-3-Carboxamide; Apixaban Impurity 26Q: What Is Apixaban Impurity 26 Q: What Is The Cas Number Of Apixaban Impurity 26; 6-(4-(5-Chloropentanamido)Phenyl)-1-(4-Methoxyphenyl)-7-Oxo-4,5,6,7-Tetrahydro-1H-Pyrazolo[3,4-C]Pyridine-3-Carboxamide? (Apixaban Impurity）
CAS编号1449510-64-8
MFCD编号:0
分子式:C25H26ClN5O4分子量:495.97
产品CID: 685220
产品分类分析化学 → 标准品 → 药典标准品和杂质标准品

相似结构搜索
InChIKey: RYEXWTWVQUUZFL-UHFFFAOYSA-N
InChI=1S/C25H26ClN5O4/c1-35-19-11-9-18(10-12-19)31-23-20(22(29-31)24(27)33)13-15-30(25(23)34)17-7-5-16(6-8-17)28-21(32)4-2-3-14-26/h5-12H,2-4,13-15H2,1H3,(H2,27,33)(H,28,
计算化学: 氢键受体数5.0氢键供体数2.0可旋转键数9.0

物理性质

MSDS等安全信息

上下游产品

4,5,6,7-tetrahydro-1-(4-methoxyphenyl)-6-(4-nitrophenyl)-7-oxo- 1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester 5-Chlorovaleroyl chloride 6-(4-aminophenyl)-1-(4-methoxyphenyl)-(4-methoxyphenyl)-7-carbonyl-1H-pyrazolo[3,4-c]-4,5,6,7-tetrahydropyridine-3-amide 3-chloro-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one

合成工艺路线路线简述

合成目标产物 Apixaban Impurity 22 主要起始原料 5-Chlorovaleryl Chloride And Apixaban Impurity 17
(文献来源)合成步骤主要原料 5-Chlorovaleryl Chloride 和 Apixaban Impurity 17

📜N-Boc-4-碘苯胺置于ammonium Hydroxide,Copper(L) Iodide,Caesium Carbonate,三乙胺,三氟乙酸,N,N'-二甲基乙二胺体系中,用四氢呋喃,1,4-二氧六环,甲醇,二氯甲烷,甲苯用作溶剂,化学反应 115.5H,反应生成阿哌沙班杂质26
参考文献:一种抗血栓药物阿哌沙班的制备方法
标题:一种抗血栓药物阿哌沙班的制备方法
摘要:本发明一种抗血栓药物用的化合物apixaban的制备方法.本发明的方法以式1中化合物11为起始原料,在亚铜试剂和无机碱的存在下与氨基保护的对碘苯胺19发生偶联反应得到化合物20,20与21经过[3+2]环合‑消除反应得到22,22脱除保护基得到23,或者20与21经过[3+2]环合反应,在酸性条件下直接发生消除反应,同时脱保护基得到23,23进行氨解反应得到24,24与5‑卤戊酰氯进行酰胺化反应得到25,25在碱性条件下环合得到阿哌沙班apixaban,或者24与5‑溴戊酰氯在碱性条件下经过酰胺化‑环合两步一锅法反应得到目标产物阿哌沙班apixaban.