CAS: 110990-07-3; (R)-2-((((9H-Fluoren-9-yl)Methoxy)Carbonyl)Amino)-6-(((Benzyloxy)Carbonyl)Amino)Hexanoic Acid

相似化合物

10009-20-8 105047-45-8 106719-44-2

上下游产品

6-[(benzyloxy)carbonyl]-L-lysineN6-[(benzyloxy)carbonyl]-L-lysine (fluorenylmethoxy)carbonyl chloride (9-fluorenyl)methyl pentafluorophenyl carbonate benzyl 4-nitrophenyl carbonateFm°C-Lys(Z)-OSu Cyclo 2-{2-[(S)-6-Benzyloxycarbonylamino-2-(9H-fluoren-9-ylmethoxycarbonylamino)-hexanoylamino]-2-methyl-propionylamino}-2-methyl-propionic acid tert-butyl ester Fm°C-Lys-OH

专利信息

专利号:US-6180767-B1
优先权日:1996-01-11
标 题 :Peptide nucleic acid conjugates
发明人：WICKSTROM ERIC; BASU SOUMITRA
权利人:UNIV JEFFERSON
摘要:Peptide nucleic acid (PNA) oligomers are conjugated to a ligand which is capable of binding to a cell surface receptor. The ligand facilitates cellular uptake of the PNA oligomer. Where the ligand is a peptide, the conjugate may be produced as a unitary molecule by first synthesizing the peptide ligand by solid phase or solution peptide synthesis, followed by synthesis of the PNA oligomer as an extension of the peptide ligand. The PNA oligomer base sequence is selected to hybridize to a target polynucleotide sequence by either triplex (dsDNA) or duplex (ssDNA; RNA) formation.