CAS: 88-97-1; 2-Carbamoylbenzoic Acid

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📜邻羧基苯甲醛置于triacetonitrile 4'-(4-Chlorophenyl)-2,2':6',2''-Terpyridine Ruthenium(II) Nitrate,盐酸羟胺,Sodium Acetate体系中,用 水 作为反应溶剂,化学反应 10.0H,以70%的收率获得产物邻氨甲酰苯甲酸
参考文献:(ar-Tpy)ru Ii(acn)3:用于醛酰胺化,烯烃氧剪断和炔烃加氧的水溶性催化剂
标题:(ar-Tpy)ru Ii(acn)3:用于醛酰胺化,烯烃氧剪断和炔烃加氧的水溶性催化剂
摘要:合成化学家一直在寻求开发新催化剂,可持续催化及其在各种有机转化中的应用.在这里,我们报告了一种新型的水溶性络合物,(ar-Tpy)ru Ii(acn)3,利用设计的具有供电子和吸出芳香族残基的三联吡啶来调节ru(II)络合物的催化活性.这些配合物对几种氧化性有机转化均表现出优异的催化活性,包括使用nh 2对醛进行后期c-h官能化在非常规水性介质中与有价值的伯酰胺发生化学反应,收率极高.建立了其多样化的催化能力,可以使用水中的低催化剂负载量直接对多种烯烃进行氧代氧化,以高产率提供醛和/或酮.它在温和条件下的智能催化活性已经过验证,可以将炔烃加成高要求的不稳定合成子,1,2-二酮和/或酸.这种常规且可持续的催化方法已成功地应用于糖基基质上,以获得手性酰胺,醛和不稳定的1,2-二酮.回收催化剂并以中等周转率重复使用.所提出的机理途径得到中间体的分离及其表征的支持.这种多方面的可持续催化是一种独特的工具,
DOI:10.1021/acs.Joc.9B00487

专利信息

专利号:US-8138330-B2
优先权日:2006-09-11
标 题 :Process for the synthesis of oligonucleotides
发明人：LEUCK MICHAEL; WOLTER ANDREAS; STUMPE ALFRED
权利人:LEUCK MICHAEL; WOLTER ANDREAS; STUMPE ALFRED; SIGMA ALDRICH CO LLC
摘要:The present invention discloses novel methods for the synthesis of oligonucleotides with nucleoside phosphoramidites on solid supports. The methods comprise the stepwise chain assembly of oligonucleotides on supports with 5′-acyl phosphoramidites. The synthesis cycles consist of a front end deprotection step which is conducted with a solution of a primary amine or a phenolate, a phosphoramidite coupling step with a 5′-acyl nucleoside phosphoramidite in the presence of an activator, a phosphite oxidation step and an optional capping step. The novel methods improve the quality of synthetic oligonucleotides due to the irreversibility of the front end deprotection step, which prevents the formation of deletion sequences, and due to the avoidance of acidic reagents in the synthesis cycles, which prevent the formation of depurination side products. The invention further discloses novel nucleoside phosphoramidite compositions wherein the phosphoramidites carry acyl front end protective groups which are cleavable with primary amines or phenolates. The invention is applicable to the synthesis of oligodeoxyribonucleotides, oligoribonucleotides and oligonucleotides with modifications in their sugar or phosphate groups.

专利号:WO-2017175101-A1
优先权日:2016-04-07
标 题:Synthesis of copper phthalocyanine using deep eutectic solvent
发明人：SHANKARLING G S; JOGLEKAR AMRUTA R
权利人:SHANKARLING G S
摘要:The present disclosure generally relates to synthesis of copper phthalocyanine. In particular, the present disclosure relates to a method of synthesis of copper phthalocyanine using deep eutectic solvent (DES), which can be carried out at low temperature, does not involve use of high boiling solvents, uses less urea and allows solvents used in the process to be recycled.

专利号:US-12391691-B2
优先权日:2018-11-16
标题:Synthesis of key intermediate of KRAS G12C inhibitor compound
发明人：PARSONS ANDREW THOMAS; COCHRAN BRIAN MCNEIL; POWAZINIK IV WILLIAM; CAPORINI MARC ANTHONY
权利人:AMGEN INC
摘要:The present invention relates to an improved, efficient, scalable process to prepare intermediate compounds, such as compound 5M, having the structure n nuseful for the synthesis of compounds that target KRAS G12C mutations, such as

专利号:US-5859237-A
优先权日:1995-04-28
标 题:Process for the production of phthalocyanine pigment
发明人：NOGUCHI HIDETO; HAYASHI MIKIO; MOMOSE MASATOSHI
权利人:TOYO INK MFG CO
摘要:A process for the production of a phthalocyanine pigment having a clear color tone, a high tinting strength and a finely milled structure by an efficient and economical process, in which the pigmentation from a phthalocyanine crude can be carried out without removing an aromatic hydrocarbon solvent used in the synthesis of the phthalocyanine crude, the process comprising thes steps of n (a) reacting phthalic anhydride or its derivative, urea or its derivative and a catalyst in an organic solvent to synthesize a phthalocyanine crude, n (b) wet-milling a slurry of the synthesized phthalocyanine crude in the presence of a milling medium without removing the aromatic hydrocarbon solvent, and n (c) removing the organic solvent from the slurry of the milled product, purifying the milled product and drying the milled product with a spray type dryer.

专利号:US-5780603-A
优先权日:1996-11-15
标题:Combinatorial synthesis of carbohydrate libraries
发明人：HINDSGAUL OLE
权利人:SYNSORB BIOTECH INC
摘要:Disclosed are methods for synthesizing very large collections of diverse thiosaccaride derivatives optionally attached to a solid support. Also disclosed are libraries of diverse thiosaccaride derviatives.

专利号:US-5965719-A
优先权日:1996-11-15
标 题:Combinatorial synthesis of carbohydrate libraries
发明人：HINDSGAUL OLE
权利人:SUNSORB BIOTECH INC
摘要:Disclosed are methods for synthesizing very large collections of diverse thiosaccharide derivatives optionally attached to a solid support. Also disclosed are libraries of diverse thiosaccharide derivatives.