CAS: 84-06-0; Thiopropazate
- 英文名称Thiopropazate
- 中文名称醋酸奋乃静
- IUPAC名称2-(4-(3-(2-chloro-10H-phenothiazin-10-yl)propyl)piperazin-1-yl)ethyl acetate
- 其它别名Thiopropazate; 4-[3-(2-Chloro-10H-Phenothiazin-10-yl)Propyl]-1-Piperazineethanol=acetate; Acetic Acid 2-[4-[3-(2-Chloro--10H-Phenothiazin-10-yl)Propyl]-1-Piperazinyl]Ethyl; Acetic Acid 2-[4-[3-(2-Chloro-10H-Phenothiazin-10-yl)Propyl]-1-Piperazinyl]Ethyl Ester; Dartal; Dartalan; 1-Piperazineethanol, 4-[3-(2-Chloro-10H-Phenothiazin-10-yl)Propyl]-, 1-Acetate; Hiopropazate
- CAS编号84-06-0
- MFCD编号:MFCD00866636
- EINECS号:201-513-4
- FDA UNII编号:0JFY081Q2X
- 分子式:C23H28ClN3O2S分子量:446.02
- 产品CID: 1829144
- 同类组份化合物CAS146-28-1 (HCl)84-06-0 (free base)
- 产品分类有机原料 → 有机杂环化合物 → 苯并噻嗪类
物理性质
- 沸点584.6 °C at 760 mmHg
- 闪点307.3 °C
- 密度1.234g/cm3
- pKa:pKa 3.20(H2O (extrap) t = 24±1 I ~ 0.002) (Uncertain);7.15(H2O (extrap) t = 24±1 I ~ 0.002) (Uncertain)
- PSA:61.32
- LogP:4.4543
- 折射率1.6
- 溶解性8.92mg/L(24 °C)
- 外观形态固体-粉末
- 储存条件Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
MSDS等安全信息
上下游产品
2-氯吩噻嗪 2-Chlorophenothiazine 92-39-7合成工艺路线路线简述
📜2-氯吩噻嗪 反应生成 醋酸奋乃静
参考文献:Anderson,Arzneimittel-Forschung/drug Research,1962,Vol. 12,P. 937-942
标题:Anderson,Arzneimittel-Forschung/drug Research,1962,Vol. 12,P. 937-942
海关参考信息
- 2903919090-氯苯
2909110000-乙醚
2912110000-甲醛
2912120000-乙醛 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:WO-2025118034-A1
优先权日:2023-12-06
标题 :Compounds active at the serotonergic 5-ht2a receptor
发明人：JORGENSON WILLIAM; TAN JINLONG; WHISH LACHLAN; BANISTER SAMUEL
权利人:Psylo Pty Ltd
摘要:The present disclosure relates to compounds of formula (I), their methods of synthesis, and their use in the treatment of mental illness or central nervous system disorders.
专利号:WO-2023230649-A1
优先权日:2022-05-30
标题:Compounds
发明人：BANISTER SAMUEL; JORGENSEN WILLIAM; TAN JINLONG; WHISH LACHLAN
权利人:Psylo Pty Ltd
摘要:The present disclosure relates to compounds of formula (I), their methods of synthesis, and their use in the treatment of mental illness or central nervous system disorders.
专利号:US-12415804-B2
优先权日:2023-06-28
标题 :Compounds for activating a serotonin receptor
发明人：BANISTER SAMUEL; JORGENSEN WILLIAM; TAN JINLONG; WHISH LACHLAN
权利人:Psylo Pty Ltd
摘要:The present disclosure relates generally to compounds, their methods of synthesis, and their use in the treatment of mental illness or central nervous system disorders.
专利号:US-12428380-B2
优先权日:2023-06-28
标 题 :Compounds
发明人：BANISTER SAMUEL; JORGENSEN WILLIAM; TAN JINLONG; WHISH LACHLAN
权利人:Psylo Pty Ltd
摘要:The present disclosure relates generally to compounds, their methods of synthesis, and their use in the treatment of mental illness or central nervous system disorders.
专利号:US-2025101038-A1
优先权日:2021-12-24
标 题 :Compounds
发明人：BANISTER SAMUEL; JORGENSEN WILLIAM; TAN JINLONG
权利人:Psylo Pty Ltd
摘要:The present disclosure relates generally to compounds, their methods of synthesis, and their use in the treatment of mental illness or central nervous system disorders.
专利号:US-2025163044-A1
优先权日:2021-12-24
标 题:Compounds
发明人：BANISTER SAMUEL; JORGENSEN WILLAM; TAN JINLONG
权利人:Psylo Pty Ltd
摘要:The present disclosure relates generally to compounds, their methods of synthesis, and their use in the treatment of mental illness or central nervous system disorders.
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Bhidayasiri R, Fahn S, Weiner WJ, Gronseth GS, Sullivan KL, Zesiewicz TA; American Academy of Neurology. Evidence-based guideline: treatment of tardive syndromes: report of the Guideline Development Subcommittee of the American Academy of Neurology. Neurology. 2013 Jul 30;81(5):463-9. doi: 10.1212/WNL.0b013e31829d86b6. Erratum in: Neurology. 2013 Nov 26;81(22):1968. 4(5787):626. doi: 10.1136/bmj.4.5787.626-c.
3: DARLING HF. Acetophenazine (Tindal) and thiopropazate (Dartal) in ambulatory psychoneurotic patients. Am J Psychiatry. 1961 Oct;118:358-9. doi: 10.1176/ajp.118.4.358. 1(7848):104-7. doi: 10.1016/s0140-6736(74)92338-1.
32:57-9. doi: 10.1093/bja/32.2.57.
合成参考文献
摘要:Archives Internationales de Pharmacodynamie et de Therapie., 149(374), 1964 []
摘要:Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 161
摘要:Gilman, A. G., L. S. Goodman, and A. Gilman. (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 6th ed. New York: Macmillan Publishing Co., Inc. 1980., p. 405
摘要:Gosselin, R.E., H.C. Hodge, R.P. Smith, and M.N. Gleason. Clinical Toxicology of Commercial Products. 4th ed. Baltimore: Williams and Wilkins, 1976., p. II-222
摘要:Osol, A. and J.E. Hoover, et al. (eds.). Remington's Pharmaceutical Sciences. 15th ed. Easton, Pennsylvania: Mack Publishing Co., 1975., p. 1028
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