专利号:US-10925977-B2 优先权日:2006-10-05 标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications 发明人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S 权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS 摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.
专利号:US-10814013-B2 优先权日:2006-10-05 标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
专利号:AU-2007308022-A2 优先权日:2006-10-05 标题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
专利号:AU-2007308022-A1 优先权日:2006-10-05 标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
专利号:US-2008107598-A1 优先权日:2006-10-05 标 题:Efficient Synthesis of Chelators for Nuclear Imaging and Radiotherapy: Compositions and Applications
专利号:AU-2007308022-B2 优先权日:2006-10-05 标题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
1: Kisin IE. On the decrease of myocardial oxygen consumption induced by chloracyzine. Br J Pharmacol. 1976 Oct;58(2):189-92. 2: Saratikov AS, Dmitrienko VF. Effects of papaverine, chloracyzine, and bencyclane on local blood flow and oxygen tension in cat brain. Cor Vasa. 1975;17(2):125-32. Russian. Polish. Russian. Russian. Russian. Russian. Russian. Russian. Czech. Russian.
合成参考文献
参考文献:10.1007/s002530051559 摘要:Parshikov IA, Freeman JP, Williams AJ, Moody JD, Sutherland JB. Biotransformation of N -acetylphenothiazine by fungi. Applied Microbiology and Biotechnology. 1999 Oct 21;52(4):553–7. doi: 10.1007/s002530051559. 摘要:SAMOILOVA ZT. [On the effect of chloracizine on the cardiovascular system]. Farmakol Toksikol. 1960 Nov;23():503–8.