CAS: 76631-46-4; 5-(2,3-Dimethylbenzyl)-1H-Imidazole

专利信息

专利号:US-RE41998-E
优先权日:1990-02-26
标题 :Compositions and methods of treatment of sympathetically maintained pain
发明人：CAMPBELL JAMES N
权利人:ARCLON THERAPEUTICS INC
摘要:Sympathetically maintained pain is treated topically by administering to the site where sympathetically maintained pain is present an α-1-adrenergic antagonist, α-2-adrenergic agonist, or other drug that depletes or blocks synthesis of sympathetic norepinephrine, known collectively as sympatholytic agents. Chemical formulas for several sympatholytic agents are given.

专利号:US-6806291-B1
优先权日:2003-10-09
标 题:Analgesic compounds, their synthesis and pharmaceutical compositions containing them
发明人：SUNKEL CARLOS; ALVAREZ-BUILLA JULIO; BAZAN NICOLAS G; VACCARINO ANTHONY
权利人:FOUNDATION FOR THE LSU HEALTH
摘要:New analgesic compounds, which are prepared by the hydrolysis of N-acylated 4-hydroxyphenylamine derivatives, their synthesis and pharmaceutical compositions containing them are disclosed. These compounds surprisingly possess high analgesic activity with little hepatotoxic effect, making them more useful than conventional non-steroidal anti-inflammatory drugs (NSAIDs) in the treatment of chronic pain.

专利号:US-4778805-A
优先权日:1987-06-18
标题:4,7-benzofurandione derivatives useful as inhibitors of leukotriene synthesis
发明人：ADAMS JULIAN; GUINDON YVAN; BELANGER PATRICE C; BELLEY MICHEL L; ROKACH JOSHUA
权利人:MERCK FROSST CANADA
摘要:4,7-Benzofurandione derivatives of Formula I, pharmaceutical compositions, and methods of treatment are disclosed. These compounds are useful as inhibitors of mammalian leukotriene biosynthesis. As such, these compounds are useful therapeutic agents for treating allergic conditions, asthma, cardiovascular disorders, inflammation, psoriasis and allergic conjunctivitis. The compounds are also useful as analgesics and as cytoprotective agents. Also disclosed are novel intermediates useful for the preparation of the 4,7-benzofurandiones of this invention. ##STR1##

专利号:US-5017583-A
优先权日:1983-04-21
标题 :Leukotriene antagonists
发明人：YOUNG ROBERT N; ROKACH JOSHUA; WILLIAMS HAYDN R; KAKUSHIMA MASATOSHI; GUINDON YVAN
权利人:MERCK FROSST CANADA INC
摘要:Compounds of the Formula I: ##STR1## and pharmaceutically acceptable salts thereof are leukotriene antagonists. These compounds inhibit SRS-A and leukotriene synthesis and are antagonists of SRS-A and are thus useful in the treatment of asthma, allergic disorders, inflammation, skin diseases and certain cardiovascular disorders.

专利号:US-4609744-A
优先权日:1983-04-21
标题 :4-oxo-benzopyran carboxylic acids
发明人：YOUNG ROBERT N; ROKACH JOSHUA; WILLIAMS HAYDN R; KAKUSHIMA MASATOSHI; GUINDON YVAN
权利人:MERCK FROSST CANADA INC
摘要:Compounds of the Formula I: ##STR1## and pharmaceutically acceptable salts thereof are leukotriene antagonists. These compounds inhibit SRS-A and leukotriene synthesis and are antagonists of SRS-A and are thus useful in the treatment of asthma, allergic disorders, inflammation, skin diseases and certain cardiovascular disorders.