专利号:US-6069149-A 优先权日:1997-01-09 标 题:Amide derivatives and intermediates for the synthesis thereof 发明人:NANBA RYOUICHI; IIZUKA TAKAO; ISHII TAKEO 权利人:TERUMO CORP 摘要:PCT No. PCT/JP98/00005 Sec. 371 Date Nov. 23, 1998 Sec. 102(e) Date Nov. 23, 1998 PCT Filed Jan. 6, 1998 PCT Pub. No. WO98/30562 PCT Pub. Date Jul. 16, 1998Novel compounds which are amide derivatives represented by general formula (I) and medicinal preparations containing the same having an eosinophilic infiltration inhibitory effect based on a potent interferon ( alpha , gamma )-inducing activity and an exellent percutaneous absorbability and being efficacious in treating allergic inflammatory diseases such as atopic dermatitis, various tumors and viral diseases. In said formula, each symbol has the following meaning: R1 and R2: each lower alkyl, etc.; X and Y: independently representing each oxygen, NR4, CR5 etc. (wherein R4 and R5 independently represent each hydrogen, an aromatic group, etc.); Z: an aromatic ring or heterocycle; R3: hydrogen, lower alkoxy, etc.; g, i and k: independently representing each an integer of from 0 to 6; h, i and l: independently representing each an integer of 0 or 1; m: an integer of from 0 to 5; and n: an integer of from 2 to 12.
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