专利号:US-7919627-B2 优先权日:2005-05-02 标题:Processes for the preparation of hydroxylamines 发明人:TANG DATONG; QIU YAO-LING; KIM HEEJIN; OR YAT SUN; WANG ZHE 权利人:ENANTA PHARM INC 摘要:The present invention relates generally to novel methods for the synthesis of O-(6-pyrazol-1-yl-pyridin-3-ylmethyl)-hydroxylamine which is an essential reagent in the synthesis of one of the bridged erythromycin derivatives and their respective pharmaceutically acceptable salts in PCT Application WO 03/097659 A1. In particular, the present invention relates to processes and intermediates for the preparation of a compound of formula (Ia):
专利号:US-9265773-B2 优先权日:2011-09-08 标题 :Tetracyclic heterocycle compounds and methods of use thereof for the treatment of viral diseases 发明人:MCCOMAS CASEY C; LIVERTON NIGEL J; HABERMANN JOERG; KOCH UWE; NARJES FRANK; LI PENG; PENG XUANJIA; SOLL RICHARD; WU HAO; PALANI ANANDAN; HE SHUWEN; DAI XING; LIU HONG; LAI ZHONG; LONDON CLARE; XIAO DONG; ZORN NICOLAS; NARGUND RAVI 权利人:MCCOMAS CASEY C; LIVERTON NIGEL J; HABERMANN JOERG; KOCH UWE; NARJES FRANK; LI PENG; PENG XUANJIA; SOLL RICHARD; WU HAO; PALANI ANANDAN; HE SHUWEN; DAI XING; LIU HONG; LAI ZHONG; LONDON CLARE; XIAO DONG; ZORN NICOLAS; NARGUND RAVI; MERCK SHARP & DOHME; MSD ITALIA SRL 摘要:The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.
专利号:WO-2024089225-A1 优先权日:2022-10-28 标题 :Process for the synthesis of methoxy substituted benzaldehyde compounds 发明人:MAYWALD MATTHIAS; VETTIGER THOMAS; GRIBKOV DENIS; TESSON JULIA 权利人:SYNGENTA CROP PROTECTION AG 摘要:The present invention provides, inter alia, a process for preparing a compound of formula (I) wherein the substituents are as defined in claim 1.
专利号:WO-2024064745-A1 优先权日:2022-09-21 标 题:Synthesis of reldesemtiv 发明人:PETERSON MATTHEW W; LU QING; MORGAN BRADLEY P; ASHCRAFT LUKE W; ANDERSEN DENISE 权利人:CYTOKINETICS INC 摘要:Provided herein is a process for the preparation of reldesemtiv and salts thereof. Also provided herein are intermediates used in this process and their preparation.
专利号:US-9790206-B2 优先权日:2013-02-27 标 题:Intermediates for use in the preparation of indazole derivatives and processes for the preparation thereof 发明人:EARY C TODD; HACHE BRUNO P; JUENGST DERRICK; SPENCER STACEY RENEE; STENGEL PETER J; WATSON DANIEL JOHN 权利人:ARRAY BIOPHARMA INC 摘要:Provided herein are novel processes for preparing a compound of Formula (I) to the use of said compound as an intermediate in novel processes for the synthesis of indazole derivatives, and to indazole intermediates and derivatives prepared by the processes described herein.
专利号:WO-2018109082-A1 优先权日:2016-12-15 标题 :Process and intermediate for the preparation of 1-(4-(2-((1-(3,4- difluorophenyl)-1h-pyrazol-3-yl)methoxy)ethyl)piperazin-1-yl)ethanone 发明人:ALMANSA ROSALES CARMEN; CAAMAÑO MOURE ANA MARÃ?A; ENJO BABÃ?O JUAN 权利人:ESTEVE LABOR DR 摘要:The present invention relates to a process for the preparation of 1-(4-(2-((1-(3,4-difluorophenyl)-1H-pyrazol-3-yl)methoxy)ethyl)piperazin-1-yl)ethanone and salts and solvates thereof and to the use of intermediates in the synthesis of these compounds. Also is provided a new intermediate compound.