CAS: 6533-73-9; Thallium(I) Carbonate

专利信息

专利号:US-5618944-A
优先权日:1993-05-05
标题:Method for the synthesis of anthrapyrazolones
发明人：ZHANG LIN-HUA; AUERBACH JOSEPH
权利人:DU PONT MERCK PHARMA
摘要:This invention relates to compounds, including 5-chloro-2-[2-[[(4-methylphenyl)sulfonyl]oxy]ethyl]-7-[2,4,6-trimethylphenyl)methoxy]anthra[1,9-cd]pyrazol-6(2H)-one and analogs thereof, which are useful as intermediates for the synthesis of anthrapyrazolone anticancer agents, including losoxantrone. This invention also relates to methods for the synthesis of anthrapyrazolone anticancer agents, including losoxantrone.

专利号:US-6166226-A
优先权日:1996-10-10
标题 :Synthesis of aryl ethers
发明人：BUCHWALD STEPHEN L; WOLFE JOHN P; PALUCKI MICHAEL
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:A method for preparing an aryl ether compound is provided in which an alcohol is reacted with an aromatic compound in the presence of a base, and a transition metal catalyst selected from the group consisting of platinum and nickel to form an aryl ether. The aromatic compound comprises an activated substituent, X, said activated substituent being a moiety such that its conjugate acid HX has a pKa of less than 5.0. The catalyst is preferably a soluble palladium complex in the presence of supporting ligands.

专利号:US-7579472-B2
优先权日:2004-09-28
标题:Efficient synthesis of 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones
发明人：MUDRYK BOGUSLAW M; CUNIERE NICOLAS; HSIEH DAU-MING; ROSSANO LUCIUS; LIANG JING; CHEN BANG-CHI; ZHANG HUIPING; ZHAO RULIN; WANG BEI; DAVID ADRIAN
权利人:BRISTOL MYERS SQUIBB CO
摘要:A novel process and intermediates thereof for making 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones of the type shown below from appropriate phenyl hydrazines is described. n nThese compounds can be useful as factor Xa inhibitors.

专利号:US-6022977-A
优先权日:1997-03-26
标 题 :Dynamic resolution of isoxazoline thioesters to isoxazoline carboxylic acids
发明人：ZHANG LIN-HUA; ANZALONE LUIGI; PESTI JAAN A; YIN JIANGUO
权利人:DU PONT PHARM CO
摘要:The present invention relates generally to a novel method for preparation of substituted isoxazolin-5-yl acetic acid in high optical purity from a stereoisomeric mixture of an esterified substituted isoxazolin-5-yl acetate. The products are useful in the synthesis of compounds for pharmaceuticals, especially the treatment of thrombolytic disorders, and agricultural products.

专利号:US-2011229397-A1
优先权日:2008-10-03
标 题:Process and apparatus for continuous flow synthesis of nanocrystals
发明人：BARTEL JOSEPH; MCKENZIE LALLIE
权利人:LIFE TECHNOLOGIES CORP
摘要:Novel reactor, systems and methods of preparing nanocrystals in a continuous flow-through process are provided. The novel reactor is highly configurable and can be modified to achieve desired reaction times of a flow through mixture. The reactor is designed to provide uniform, efficient heating of the reaction mixture.

专利号:US-2006025421-A1
优先权日:2004-06-25
标 题:Pyridyl piperazines for the treatment of CNS disorders
发明人：BRODNEY MICHAEL A
权利人:PFIZER
摘要:This invention is directed to compounds of Formula I and to pharmaceutical compositions comprising the compound of Formula I. n n where the dashed line represents an optional double bond; and where n is 1 or 2, and Ar 1 , Ar 2 , . . . and Z are as defined in the specification. The invention is also directed to a method of treating a disorder or condition that can be treated by altering serotonin-mediated neurotransmission, such as migraine, headache, cluster headache, anxiety, depression, etc. This invention is also directed to intermediates useful in the synthesis of compounds of Formula I.